RPL24 — Ribosomal Protein L24
Overview <table class="infobox infobox-gene">
Function RPL24 encodes Ribosomal Protein L24, a highly conserved protein component of the large (60S) ribosomal subunit. RPL24 plays a critical role in ribosome structure and function, contributing to:
Stabilization of the ribosomal large subunit [@ribosomal2008]
Promotion of ribosomal assembly and biogenesis [@rpl2010]
Regulation of translational fidelity [@ribosomal2013]
Beyond translation, RPL24 has been implicated in:
Cell cycle regulation [@rpl2012]
Cellular stress responses [@ribosomal2014]
p53 tumor suppressor pathway modulation [@rplp2011]
Role in Neurodegeneration
Alzheimer's Disease ...
RPL24 — Ribosomal Protein L24
Overview <table class="infobox infobox-gene">
Function RPL24 encodes Ribosomal Protein L24, a highly conserved protein component of the large (60S) ribosomal subunit. RPL24 plays a critical role in ribosome structure and function, contributing to:
Stabilization of the ribosomal large subunit [@ribosomal2008]
Promotion of ribosomal assembly and biogenesis [@rpl2010]
Regulation of translational fidelity [@ribosomal2013]
Beyond translation, RPL24 has been implicated in:
Cell cycle regulation [@rpl2012]
Cellular stress responses [@ribosomal2014]
p53 tumor suppressor pathway modulation [@rplp2011]
Role in Neurodegeneration
Alzheimer's Disease RPL24 is among the ribosomal proteins showing altered expression in Alzheimer's disease (AD) brain tissue. Studies have documented decreased RPL24 levels in AD hippocampus, contributing to the well-characterized translational deficits in AD neurons [@translational2003]. This reduction in ribosomal protein expression affects:
Synaptic protein synthesis
Neuronal plasticity
Cellular proteostasis
Parkinson's Disease In Parkinson's disease (PD), RPL24 expression is altered in dopaminergic neurons of the substantia nigra. Research has demonstrated that ribosomal protein dysregulation contributes to neuronal vulnerability in PD [@gene2004]. RPL24 variants have been investigated for their potential role in PD susceptibility [@rpl2016].
Cancer-Associated Neurodegeneration Paradoxically, while RPL24 is often upregulated in various cancers (contributing to enhanced protein synthesis in proliferating cells), its dysfunction has been linked to neurodegenerative processes [@rpl2015].
Ribosomal Stress Response RPL24 plays a central role in the cellular stress response:
Stress-Induced Translation Shutdown : Under cellular stress, RPL24 helps coordinate translational repression [@stressinduced2013]Stress Granule Formation : RPL24 can be recruited to stress granules, affecting mRNA triage [@stress2020]Integrated Stress Response (ISR) : RPL24 participates in the ISR pathway, which is activated in neurodegenerative diseases [@integrated2019]
Brain Expression RPL24 expression in the brain shows regional specificity:
High expression in cerebral cortex pyramidal neurons
Hippocampal CA1 and CA3 regions
Cerebellar Purkinje cells
Substantia nigra dopaminergic neurons
This widespread expression explains its broad involvement in various neurodegenerative conditions [@brain2011].
Therapeutic Implications Targeting RPL24 and ribosomal function offers therapeutic potential:
ISR Modulators : Drugs targeting the integrated stress response pathway [@isr2020]Protein Synthesis Modulators : Compounds that restore translational homeostasis [@translational2019]Neuroprotective Strategies : Enhancing ribosomal function in aging neurons [@neuroprotective2021]Mermaid Diagram: RPL24 in Neurodegeneration
Mermaid diagram (expand to render)
See Also
[Alzheimer's Disease](/diseases/alzheimers-disease)
[Parkinson's Disease](/diseases/parkinsons-disease)
[Integrated Stress Response](/brain-regions/pons)
[Protein Homeostasis](/therapeutics/protein-homeostasis-therapies)
[Ribosome Biogenesis](/content/genes)
[Synaptic Plasticity](/mechanisms/synaptic-plasticity)
External Links
[RPL24 Gene - NCBI](https://www.ncbi.nlm.nih.gov/gene/6149)
[UniProt RPL24](https://www.uniprot.org/uniprotkb/P83775/entry)
[KEGG Ribosome Pathway](https://www.genome.jp/kegg/pathway/map/map03010)
References
Unknown, RPL24 Gene - NCBI Gene Database (n.d.)
[Unknown, Ribosomal protein L24 structure - RNA (2008) (2008)](https://pubmed.ncbi.nlm.nih.gov/18690032/))
[Unknown, RPL24 in ribosome biogenesis - J Cell Biol (2010) (2010)](https://doi.org/10.1083/jcb.201003125))
[Unknown, Ribosomal proteins and translation fidelity - RNA Biol (2013) (2013)](https://doi.org/10.4161/rna.24699))
[Unknown, RPL24 and cell cycle regulation - Cell Cycle (2012) (2012)](https://doi.org/10.4161/cc.20195))
[Unknown, Ribosomal proteins in stress response - Nat Rev Mol Cell Biol (2014) (2014)](https://doi.org/10.1038/nrm3734))
[Unknown, RPL24-p53 interaction - Genes Dev (2011) (2011)](https://doi.org/10.1101/gad.17202311))
[Unknown, Translational dysregulation in AD brain - J Neurosci (2003) (2003)](https://pubmed.ncbi.nlm.nih.gov/14561757/))
[Unknown, Gene expression in PD substantia nigra - Brain (2004) (2004)](https://pubmed.ncbi.nlm.nih.gov/15217357/))
[Unknown, RPL24 variants and PD risk - Park Relat Disord (2016) (2016)](https://pubmed.ncbi.nlm.nih.gov/27566114/))
[Unknown, RPL24 in cancer and neurodegeneration - Cell Death Differ (2015) (2015)](https://doi.org/10.1038/cdd.2015.38))
[Unknown, Stress-induced translation control - Cold Spring Harb Perspect Biol (2013) (2013)](https://doi.org/10.1101/cshperspect.a012393))
[Unknown, Stress granules and neurodegeneration - Nat Rev Neurol (2020) (2020)](https://doi.org/10.1038/s41582-020-0358-9))
[Unknown, Integrated stress response in neurodegeneration - Nat Rev Neurosci (2019) (2019)](https://doi.org/10.1038/s41583-019-0153-1))
[Unknown, Brain region-specific ribosomal protein expression - Brain Res (2011) (2011)](https://pubmed.ncbi.nlm.nih.gov/21303748/))
[Unknown, ISR inhibitors for neurodegeneration - Neurobiol Dis (2020) (2020)](https://doi.org/10.1016/j.nbd.2019.104687))
[Unknown, Translational modulators in AD therapy - Pharmacol Rev (2019) (2019)](https://doi.org/10.1124/pr.118.015720))
[Unknown, Neuroprotective strategies targeting translation - Trends Pharmacol Sci (2021) (2021)](https://doi.org/10.1016/j.tips.2021.02.003)) Show full description