Sema3F Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Sema3F Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
SEMA3F (Semaphorin 3F) encodes a secreted axonal guidance molecule critical for neuronal development, synaptic organization, and vascular patterning. As a member of the class 3 semaphorins, SEMA3F signals through neuropilin-2 (NRP2) and plexin receptor complexes to exert its effects on axonal repulsion and dendritic growth. Beyond development, SEMA3F plays roles in cancer suppression, immune regulation, and has been implicated in neurodegenerative diseases including Alzheimer's disease and amyotrophic lateral sclerosis. [@semaf2006]
<div class="infobox infobox-gene"> [@class2005]
<table> [@semaf2010]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Semaphorin 3F</th></tr> [@semaphorins2017]
<tr><td><strong>Gene Symbol</strong></td><td>SEMA3F</td></tr> [@semaf2014]
<tr><td><strong>Full Name</strong></td><td>Semaphorin 3F</td></tr> [@targeting2019]
<tr><td><strong>Chromosome</strong></td><td>3p21.31</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[10715](https://www.ncbi.nlm.nih.gov/gene/10715)</td></tr>
<tr><td><strong>OMIM</strong></td><td>[601124](https://www.omim.org/entry/601124)</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000061656</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q13241](https://www.uniprot.org/uniprot/Q13241)</td></tr>
<tr><td><strong>Protein Class</strong></td><td>Axonal guidance molecule (Class 3 Semaphorin)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Cancer (suppressor), Potential roles in AD/ALS</td></tr>
</table>
</div>
SEMA3F is a 810-amino acid secreted protein with the following domain organization:
SEMA3F signals through a dual-receptor system:
| Receptor | Co-receptor | Function |
|----------|-------------|----------|
| Plexin A3 (PLXNA3) | NRP2 | Axon repulsion in CNS |
| Plexin A4 (PLXNA4) | NRP2 | Spinal cord patterning |
| NRP2 | NRP2 alone | Partial signaling |
Upon receptor binding, SEMA3F triggers downstream cascades:
SEMA3F exhibits region-specific expression in the developing and adult brain:
During development, SEMA3F provides repulsive cues for:
SEMA3F regulates:
At mature synapses, SEMA3F:
SEMA3F is a potent inhibitor of:
SEMA3F functions as a tumor suppressor:
| Cancer Type | Evidence | Mechanism |
|-------------|----------|----------|
| Lung cancer | Reduced expression in tumors | Promotes metastasis |
| Breast cancer | Loss of heterozygosity | Enhanced angiogenesis |
| Ovarian cancer | Epigenetic silencing | Cell survival |
| Colorectal cancer | Reduced expression | Migration/invasion |
Therapeutic potential: SEMA3F-based therapies for anti-angiogenic treatment.
Multiple lines of evidence connect SEMA3F to AD:
SEMA3F is a critical axonal guidance molecule with diverse functions in neuronal development, synaptic organization, and disease. As a tumor suppressor with roles in cancer and neurodegeneration, SEMA3F represents a promising therapeutic target for both oncology and neurological disorders.
Sema3F Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Sema3F Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
The following diagram shows the key molecular relationships involving SEMA3F Gene discovered through SciDEX knowledge graph analysis: