SEPTIN10 (Septin 10) is a member of the septin family of GTP-binding proteins that are essential for cytokinesis, cell polarity, and cellular organization. Septins form hetero-oligomeric complexes that function as scaffolds and barriers in various cellular processes. In [neurons](/entities/neurons), septins play important roles in synaptic function, axonal transport, and have been implicated in neurodegenerative diseases[@mostowy2011].
Gene Information
<div class="infobox infobox-gene">
| Property | Value | |----------|-------| | Gene Symbol | SEPTIN10 | | Gene Name | Septin 10 | | Chromosomal Location | 2q36.3 | | NCBI Gene ID | 10244 | | UniProt ID | Q9NSE2 | | Ensembl ID | ENSG00000165799 | | Gene Type | Protein Coding |
</div>
Protein Structure
SEPTIN10 belongs to the septin family characterized by:
GTP-binding domain: Conserved P-loop NTP-binding region
Polybasic region: For membrane association
NC terminal: Variable region
Coiled-coil domains: For protein-protein interactions
Septins assemble into filaments and rings, forming higher-order structures essential for their cellular functions[@kinoshita2003].
Biological Functions
Cytokinesis
Forms contractile ring during cell division
Serves as diffusion barrier
Recruits cell division proteins
Cell Polarity
Establishes cortical domains
Maintains cell shape
Regulates membrane organization
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title: SEPTIN10 Gene
SEPTIN10 Gene
Overview
SEPTIN10 (Septin 10) is a member of the septin family of GTP-binding proteins that are essential for cytokinesis, cell polarity, and cellular organization. Septins form hetero-oligomeric complexes that function as scaffolds and barriers in various cellular processes. In [neurons](/entities/neurons), septins play important roles in synaptic function, axonal transport, and have been implicated in neurodegenerative diseases[@mostowy2011].
Gene Information
<div class="infobox infobox-gene">
| Property | Value | |----------|-------| | Gene Symbol | SEPTIN10 | | Gene Name | Septin 10 | | Chromosomal Location | 2q36.3 | | NCBI Gene ID | 10244 | | UniProt ID | Q9NSE2 | | Ensembl ID | ENSG00000165799 | | Gene Type | Protein Coding |
</div>
Protein Structure
SEPTIN10 belongs to the septin family characterized by:
GTP-binding domain: Conserved P-loop NTP-binding region
Polybasic region: For membrane association
NC terminal: Variable region
Coiled-coil domains: For protein-protein interactions
Septins assemble into filaments and rings, forming higher-order structures essential for their cellular functions[@kinoshita2003].
Biological Functions
Cytokinesis
Forms contractile ring during cell division
Serves as diffusion barrier
Recruits cell division proteins
Cell Polarity
Establishes cortical domains
Maintains cell shape
Regulates membrane organization
Neuronal Functions
Synaptic vesicle organization
Axonal transport regulation
Dendrite morphogenesis
Neurotransmitter release
Expression Pattern
SEPTIN10 is expressed in:
Brain (neurons and glia)
Testis
Various epithelial tissues
Proliferating cells
In neurons, septins are enriched in:
Synaptic terminals
Axon initial segments
[Dendritic spines](/mechanisms/dendritic-spines)
Role in Neurodegeneration
Alzheimer's Disease
SEPTIN10 dysregulation is implicated in AD:
Amyloid-β interaction: Septins may interact with [Aβ](/proteins/amyloid-beta)
[Tau](/proteins/tau) pathology: Septin involvement in tau aggregation