SLC15A2 — Solute Carrier Family 15 Member 2 (Peptide Transporter 2)

SLC15A2 — Solute Carrier Family 15 Member 2 (Peptide Transporter 2)

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">SLC15A2 — Solute Carrier Family 15 Member 2 (Peptide Transporter 2)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>SLC15A2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Solute Carrier Family 15 Member 2 (Peptide Transporter 2)</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>3q27</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>[6565](https://www.ncbi.nlm.nih.gov/gene/6565)</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>[607456](https://www.omim.org/entry/607456)</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000065427</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>[O75374](https://www.uniprot.org/uniprot/O75374)</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>Potential role in neuropeptide homeostasis</td>
</tr>
</table>

{{.infobox .infobox-gene}}
Peptide transporter 2 (PepT2). High-affinity peptide transporter. Expressed in kidney and brain. Important for reabsorption of peptides in kidney and potential neuropeptide clearance in brain.

Overview

SLC15A2 is a human gene encoding PepT2 (Peptide Transporter 2), a high-affinity proton-coupled oligopeptide transporter[@ncbi]. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.

Function

SLC15A2 — Solute Carrier Family 15 Member 2 (Peptide Transporter 2)

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">SLC15A2 — Solute Carrier Family 15 Member 2 (Peptide Transporter 2)</th>
</tr>
<tr>
<td class="label">Symbol</td>
<td>SLC15A2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Solute Carrier Family 15 Member 2 (Peptide Transporter 2)</td>
</tr>
<tr>
<td class="label">Chromosome</td>
<td>3q27</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>[6565](https://www.ncbi.nlm.nih.gov/gene/6565)</td>
</tr>
<tr>
<td class="label">OMIM</td>
<td>[607456](https://www.omim.org/entry/607456)</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000065427</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>[O75374](https://www.uniprot.org/uniprot/O75374)</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td>Potential role in neuropeptide homeostasis</td>
</tr>
</table>

{{.infobox .infobox-gene}}
Peptide transporter 2 (PepT2). High-affinity peptide transporter. Expressed in kidney and brain. Important for reabsorption of peptides in kidney and potential neuropeptide clearance in brain.

Overview

SLC15A2 is a human gene encoding PepT2 (Peptide Transporter 2), a high-affinity proton-coupled oligopeptide transporter[@ncbi]. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration.

Function

Peptide Transport Mechanism

SLC15A2 encodes a high-affinity peptide transporter that uses a proton gradient to drive the active transport of di- and tri-peptides across cell membranes[@newstead2015]. Unlike its paralog SLC15A1 (PEPT1), which is expressed in intestinal epithelium, SLC15A2 exhibits higher affinity for peptides and is primarily expressed in renal proximal tubules and the brain[@brandsch2013].

Brain Expression

In the brain, PepT2 is expressed at the [blood-brain barrier](/entities/blood-brain-barrier) and in choroid plexus, where it plays a crucial role in clearing neuropeptides from the cerebrospinal fluid[@zlokovic2008]. This function is particularly important for maintaining neuropeptide homeostasis, as many neuropeptides serve as signaling molecules involved in cognitive function, mood regulation, and circadian rhythms[@redzic2014].

Disease Associations

Neurodegenerative Disease Research

While direct disease-causing mutations in SLC15A2 are not well-established, the transporter has been studied in the context of:

Expression Patterns

Tissue Distribution

• Kidney: High expression in proximal tubules — primary site for peptide reabsorption
• Brain: Expressed in choroid plexus, ependymal cells, and at blood-brain barrier
• Lung: Lower expression in alveolar epithelium
• Mammary gland: Expression during lactation[@shen1999]

Cellular Localization

PepT2 is primarily localized to the apical membrane of epithelial cells, where it functions as an uptake transporter for peptide reabsorption[@tamai2004].

Clinical Relevance

Pharmacogenomics

SLC15A2 polymorphisms can affect the pharmacokinetics of peptide-derived drugs, including certain antibiotics and antiviral agents[@bruer2010].

Therapeutic Implications

Understanding PepT2 function may inform drug delivery strategies for CNS disorders, as the transporter represents a potential gateway for peptide-based therapeutics[@gupta2014].

Key Publications

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)
• [SLC15A1 — Solute Carrier Family 15 Member 1](/genes/slc15a1)

External Links

• [NCBI Gene: 6565](https://www.ncbi.nlm.nih.gov/gene/6565)
• [Ensembl: ENSG00000065427](https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000065427)
• [UniProt: O75374](https://www.uniprot.org/uniprot/O75374)

References