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STUB1 — CHIP

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gene605 wordssynced 2026-04-02

STUB1 — CHIP

Pathway Diagram

flowchart TD STUB1["STUB1 E3 Ubiquitin Ligase"] TARDBP["TDP-43 Protein"] BAG3["BAG3 Co-chaperone"] HSPB8["Heat Shock Protein B8"] MTOR["mTOR Kinase"] ATG10["ATG10 Autophagy Factor"] ATG12["ATG12 Autophagy Factor"] MAP1LC3B["LC3B Autophagy Marker"] LAMP2A["LAMP2A Lysosomal Protein"] CALCINEURIN["Calcineurin Phosphatase"] AUTOPHAGY["Autophagy Pathway"] PROTEIN_AGG["Protein Aggregation"] ALS["Amyotrophic Lateral Sclerosis"] NEURODEGENERATION["Neurodegeneration"] STUB1 -->|"ubiquitination"| TARDBP STUB1 -->|"co-chaperone interaction"| BAG3 STUB1 -->|"chaperone regulation"| HSPB8 STUB1 -->|"pathway regulation"| MTOR STUB1 -->|"activates"| ATG10 STUB1 -->|"activates"| ATG12 STUB1 -->|"activates"| CALCINEURIN ATG10 -->|"conjugation system"| AUTOPHAGY ATG12 -->|"conjugation system"| AUTOPHAGY MAP1LC3B -->|"autophagosome formation"| AUTOPHAGY LAMP2A -->|"chaperone-mediated autophagy"| AUTOPHAGY TARDBP -->|"aggregation"| PROTEIN_AGG PROTEIN_AGG -->|"cellular toxicity"| ALS ALS -->|"motor neuron death"| NEURODEGENERATION classDef central fill:#006494,color:#e0e0e0 classDef protective fill:#1b5e20,color:#e0e0e0 classDef pathological fill:#ef5350,color:#0d0d1a classDef regulatory fill:#4a1a6b,color:#e0e0e0 class STUB1 central class AUTOPHAGY,ATG10,ATG12,MAP1LC3B,LAMP2A protective class PROTEIN_AGG,NEURODEGENERATION,ALS pathological class MTOR,CALCINEURIN,BAG3,HSPB8 regulatory

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