Syn1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@garcia2001]
| Attribute | Value | [@fassio2013] |-----------|-------| [@davidsson2011] | Gene Symbol | SYN1 | [@cesca2010] | Full Name | Synapsin-1 | | Chromosomal Location | Xp11.23 | | NCBI Gene ID | [6853](https://www.ncbi.nlm.nih.gov/gene/6853) | | Ensembl ID | ENSG00000102057 | | UniProt ID | [P17600](https://www.uniprot.org/uniprot/P17600) | | OMIM ID | [313440](https://www.omim.org/313440) | | Gene Family | Synapsin family | | Protein Class | Phosphoprotein, synaptic vesicle |
</div>}
Pathway Diagram
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SYN1 Gene
Introduction
Syn1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-gene"> [@garcia2001]
| Attribute | Value | [@fassio2013] |-----------|-------| [@davidsson2011] | Gene Symbol | SYN1 | [@cesca2010] | Full Name | Synapsin-1 | | Chromosomal Location | Xp11.23 | | NCBI Gene ID | [6853](https://www.ncbi.nlm.nih.gov/gene/6853) | | Ensembl ID | ENSG00000102057 | | UniProt ID | [P17600](https://www.uniprot.org/uniprot/P17600) | | OMIM ID | [313440](https://www.omim.org/313440) | | Gene Family | Synapsin family | | Protein Class | Phosphoprotein, synaptic vesicle |
</div>}
Pathway Diagram
Mermaid diagram (expand to render)
Overview
The SYN1 gene (Synapsin-1) encodes a neuronal phosphoprotein associated with synaptic vesicles, located on the X chromosome (Xp11.23). Synapsins play essential roles in synaptogenesis, synaptic plasticity, and neurotransmitter release. SYN1 is critical for maintaining synaptic vesicle pools and regulating vesicle release kinetics. The gene spans approximately 50 kb and consists of multiple exons that undergo alternative splicing to produce multiple isoforms.
Gene Structure
Genomic Organization
The SYN1 gene exhibits complex genomic structure:
Chromosomal Location: Xp11.23
Genomic Span: ~50 kb
Exon Count: Multiple exons (13+)
Alternative Splicing: Produces multiple isoforms (I, II, III)
PMID: 7544357(https://pubmed.ncbi.nlm.nih.gov/7544357/) - Greengard P, et al. The synapsins. Annu Rev Neurosci. 1991
PMID: 11259660(https://pubmed.ncbi.nlm.nih.gov/11259660/) - Garcia CC, et al. Synapsin I in epilepsy. Brain Res. 2001
PMID: 23452922(https://pubmed.ncbi.nlm.nih.gov/23452922/) - Fassio A, et al. SYN1 loss-of-function mutations in autism. Nat Genet. 2013
PMID: 20847430(https://pubmed.ncbi.nlm.nih.gov/20847430/) - Davidsson P, et al. CSF synapsin in Alzheimer's disease. J Neural Transm. 2011
Background
The study of Syn1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.