<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">SYT2 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>SYT2</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Synaptotagmin-2</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>1q21.3</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>11044</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000138294</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>Q9H0Y5</td>
</tr>
<tr>
<td class="label">Disease</td>
<td>Association Type</td>
</tr>
<tr>
<td class="label">Myasthenia Gravis</td>
<td>Autoimmune Target</td>
</tr>
<tr>
<td class="label">ALS</td>
<td>Risk Modulator</td>
</tr>
<tr>
<td class="label">Parkinson's Disease</td>
<td>Risk Modulator</td>
</tr>
<tr>
<td class="label">Congenital Myasthenic Syndrome</td>
<td>Causative</td>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Antibody therapy</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Approach</td>
</tr>
<tr>
<td class="label">Antibody therapy</td>
<td>Target autoantibodies</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>Restore SYT2 function</td>
</tr>
<tr>
<td class="label">Calcium modulators</td>
<td>Modulate synaptic function</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/aging" style="color:#ef9a9a">Aging</a>, <a href="/wiki/inflammation" style="color:#ef9a9a">Inflammation</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">31 edges</a></td>
</tr>
</table>
Syt2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Syt2 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@herrmann2014]
SYT2 (Synaptotagmin-2) encodes Synaptotagmin-2, a calcium sensor protein essential for synaptic vesicle fusion and neurotransmitter release. [@bacaj2015]
The SYT2 gene encodes Synaptotagmin-2 (Syt2), a member of the synaptotagmin family of calcium-binding proteins. Syt2 is characterized by:
Syt2 shows specific expression:
Syt2 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Syt2 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
SYT2 is expressed predominantly in the nervous system:
Synaptotagmin-2 is a calcium sensor for synaptic vesicle exocytosis:
SYT2 is an autoantibody target in some myasthenia gravis cases:
In ALS, SYT2 alterations contribute to:
SYT2 mutations can cause peripheral neuropathy:
The following diagram shows the key molecular relationships involving SYT2 Gene discovered through SciDEX knowledge graph analysis: