TIC1 (Transcriptional Intermediary Factor 1), also known as NCoA-1 (Nuclear Receptor Coactivator 1), is a nuclear receptor coactivator that plays a critical role in transcriptional regulation. It functions as a scaffold protein that recruits additional coactivators and chromatin remodeling complexes to enhance gene transcription.
Gene Information
<div class="infobox infobox-gene"> [@lonard2005] | Property | Value | [@wang2020] |----------|-------| | Gene Symbol | TIC1 | | Full Name | Transcriptional Intermediary Factor 1 | | Aliases | NCoA-1, SRC-1, NRC-1 | | Chromosomal Location | 2p23.3 | | NCBIB Gene ID | [10898](https://www.ncbi.nlm.nih.gov/gene/10898) | | OMIM ID | [603484](https://www.omim.org/entry/603484) | | Ensembl ID | ENSG00000100994 | | UniProt ID | [Q13448](https://www.uniprot.org/uniprot/Q13448) | | Associated Diseases | Breast Cancer, Prostate Cancer, Endometriosis, Alzheimer's Disease | </div>
Function
Transcriptional Coactivator Activity
TIC1 functions as a master transcriptional regulator through several mechanisms:
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TIC1 Gene
Overview
TIC1 (Transcriptional Intermediary Factor 1), also known as NCoA-1 (Nuclear Receptor Coactivator 1), is a nuclear receptor coactivator that plays a critical role in transcriptional regulation. It functions as a scaffold protein that recruits additional coactivators and chromatin remodeling complexes to enhance gene transcription.
Gene Information
<div class="infobox infobox-gene"> [@lonard2005] | Property | Value | [@wang2020] |----------|-------| | Gene Symbol | TIC1 | | Full Name | Transcriptional Intermediary Factor 1 | | Aliases | NCoA-1, SRC-1, NRC-1 | | Chromosomal Location | 2p23.3 | | NCBIB Gene ID | [10898](https://www.ncbi.nlm.nih.gov/gene/10898) | | OMIM ID | [603484](https://www.omim.org/entry/603484) | | Ensembl ID | ENSG00000100994 | | UniProt ID | [Q13448](https://www.uniprot.org/uniprot/Q13448) | | Associated Diseases | Breast Cancer, Prostate Cancer, Endometriosis, Alzheimer's Disease | </div>
Function
Transcriptional Coactivator Activity
TIC1 functions as a master transcriptional regulator through several mechanisms:
Nuclear receptor interaction: Binds to ligand-bound nuclear receptors including estrogen receptor (ER), progesterone receptor (PR), thyroid hormone receptor (TR), and retinoic acid receptor (RAR)
Histone acetylation recruitment: Recruits p300/CBP histone acetyltransferases to chromatin
Chromatin remodeling: Attracts SWI/SNF complexes for nucleosome displacement
Mediator complex recruitment: Facilitates interaction between transcription factors and RNA polymerase II
Protein Domains
TIC1 contains several functional domains:
N-terminal basic helix-loop-helix (bHLH): DNA binding and protein interactions
PAS domains (PAS-A, PAS-B): Protein-protein interactions and signal sensing