WNT8B (Wingless-Type MMTV Integration Site Family Member 8B) is a gene encoding a secreted signaling protein that plays crucial roles in embryonic development, neuronal differentiation, and adult brain function. Wnt signaling is evolutionarily conserved and critical for neural development, synapse formation, and neurodegeneration[@clevers2012].
Gene Information
<div class="infobox infobox-gene">
| Property | Value | |----------|-------| | Gene Symbol | WNT8B | | Gene Name | Wingless-Type MMTV Integration Site Family Member 8B | | Chromosomal Location | 10p26.3 | | NCBI Gene ID | 7479 | | OMIM ID | 605396 | | UniProt ID | Q9Y5Q2 | | Ensembl ID | ENSG00000070193 | | Gene Type | Protein Coding |
</div>
Protein Structure
The WNT8B protein is a member of the Wnt family, which are secreted lipoglycoproteins characterized by:
N-terminal signal peptide: Directs secretion
Wnt domain: ~350 amino acids, the functional core
Multiple cysteine residues: Form disulfide bonds for proper folding
Lipid modification site: C-terminal palmitoylation essential for signaling
The protein undergoes post-translational modifications including glycosylation and palmitoylation, which are essential for its secretion and function[@willert2003].
WNT8B (Wingless-Type MMTV Integration Site Family Member 8B) is a gene encoding a secreted signaling protein that plays crucial roles in embryonic development, neuronal differentiation, and adult brain function. Wnt signaling is evolutionarily conserved and critical for neural development, synapse formation, and neurodegeneration[@clevers2012].
Gene Information
<div class="infobox infobox-gene">
| Property | Value | |----------|-------| | Gene Symbol | WNT8B | | Gene Name | Wingless-Type MMTV Integration Site Family Member 8B | | Chromosomal Location | 10p26.3 | | NCBI Gene ID | 7479 | | OMIM ID | 605396 | | UniProt ID | Q9Y5Q2 | | Ensembl ID | ENSG00000070193 | | Gene Type | Protein Coding |
</div>
Protein Structure
The WNT8B protein is a member of the Wnt family, which are secreted lipoglycoproteins characterized by:
N-terminal signal peptide: Directs secretion
Wnt domain: ~350 amino acids, the functional core
Multiple cysteine residues: Form disulfide bonds for proper folding
Lipid modification site: C-terminal palmitoylation essential for signaling
The protein undergoes post-translational modifications including glycosylation and palmitoylation, which are essential for its secretion and function[@willert2003].