Ideas Dashboard

Overview

This dashboard provides comprehensive statistics and analytics for therapeutic ideas in NeuroWiki's invention lab. Ideas represent novel therapeutic concepts built from mechanistic evidence for neurodegenerative diseases.

Summary Statistics

| Metric | Value |
|--------|-------|
| Total Idea Pages | 103[@neurowiki2026] |
| Ranked Ideas | 25[@neurowiki2026] |
| Unranked/Placeholder | 78 |
| AD-Focused Ideas | 68[@neurowiki2026] |
| PD-Focused Ideas | 62[@neurowiki2026] |
| ALS-Focused Ideas | 45 |
| FTD-Focused Ideas | 38 |

Ideas by Category

Target-Based Approaches

Mechanisms targeting specific proteins or pathways:

| Category | Count | Examples |
|----------|-------|----------|
| [Alpha-synuclein](/proteins/alpha-synuclein) targeting | 12 | [Payload: Alpha-synuclein RNAi](/ideas/payload-crispri-snca-silencing) |
| [Tau](/proteins/tau) targeting | 8 | [Tau PROTAC degrader](/ideas/payload-tau-protac-degrader) |
| Neuroinflammation | 15 | [NLRP3 inhibitor](/ideas/cns-nlrp3-inflammasome-inhibitor) |
| Mitochondrial function | 9 | [SARM1 inhibitor](/ideas/payload-sarm1-nadase-inhibitor) |
| Protein clearance | 11 | [HDAC6 agonist](/ideas/hdac6-agonist-aggrephagy) |

Modality Distribution

| Modality | Count |
|----------|-------|
| Small molecule | 42 |
| Antibody/Protein | 28 |
| Gene therapy | 18 |
| Cell therapy | 8 |
| Combination therapy | 7 |

Mechanism of Action

Overview

This dashboard provides comprehensive statistics and analytics for therapeutic ideas in NeuroWiki's invention lab. Ideas represent novel therapeutic concepts built from mechanistic evidence for neurodegenerative diseases.

Summary Statistics

| Metric | Value |
|--------|-------|
| Total Idea Pages | 103[@neurowiki2026] |
| Ranked Ideas | 25[@neurowiki2026] |
| Unranked/Placeholder | 78 |
| AD-Focused Ideas | 68[@neurowiki2026] |
| PD-Focused Ideas | 62[@neurowiki2026] |
| ALS-Focused Ideas | 45 |
| FTD-Focused Ideas | 38 |

Ideas by Category

Target-Based Approaches

Mechanisms targeting specific proteins or pathways:

| Category | Count | Examples |
|----------|-------|----------|
| [Alpha-synuclein](/proteins/alpha-synuclein) targeting | 12 | [Payload: Alpha-synuclein RNAi](/ideas/payload-crispri-snca-silencing) |
| [Tau](/proteins/tau) targeting | 8 | [Tau PROTAC degrader](/ideas/payload-tau-protac-degrader) |
| Neuroinflammation | 15 | [NLRP3 inhibitor](/ideas/cns-nlrp3-inflammasome-inhibitor) |
| Mitochondrial function | 9 | [SARM1 inhibitor](/ideas/payload-sarm1-nadase-inhibitor) |
| Protein clearance | 11 | [HDAC6 agonist](/ideas/hdac6-agonist-aggrephagy) |

Modality Distribution

| Modality | Count |
|----------|-------|
| Small molecule | 42 |
| Antibody/Protein | 28 |
| Gene therapy | 18 |
| Cell therapy | 8 |
| Combination therapy | 7 |

Mechanism of Action

• Aggregation inhibitors — Prevent toxic protein aggregation
• Protein degraders — PROTACs, molecular glues
• Gene silencing — ASO, RNAi, CRISPR
• Cell replacement — iPSC therapies
• Modulation — Target activation or inhibition

Top-Ranked Ideas

Based on the 10-dimension rubric (Novelty, Mechanistic Rationale, Root-Cause Coverage, Delivery Feasibility, Safety Plausibility, Combinability, Biomarker Availability, De-risking Path, Multi-disease Potential, Patient Impact):

| Rank | Idea | Score | Key Mechanism |
|------|------|-------|---------------|
| 1 | [SIRT1 + NAD+ Combination](/ideas/combo-sirt1-nad-epigenetic-metabolic) | 85 | Epigenetic-metabolic |
| 2 | [C9orf72 RNA Targeting](/ideas/c9orf72-rna-targeting-dpr-reduction) | 84 | RNA silencing |
| 3 | [NfL-Guided Neuroprotection](/ideas/biomarker-nfl-neuroprotection-threshold) | 84 | Biomarker-driven |
| 4 | [Insulin + GLP-1 Combo](/ideas/payload-insulin-glp1-combo-therapy) | 82 | Metabolic modulation |
| 5 | [Microglia State Editing](/ideas/payload-microglia-state-editing-trem2-lxr) | 82 | Cell state modulation |

Disease Coverage

Alzheimer's Disease (AD)

68 ideas targeting amyloid, tau, neuroinflammation, synaptic loss, and metabolic dysfunction.

Parkinson's Disease (PD)

62 ideas focused on alpha-synuclein, LRRK2, GBA1, mitophagy, and dopamine [neurons](/entities/neurons).

Amyotrophic Lateral Sclerosis (ALS)

45 ideas targeting SOD1, [C9orf72](/entities/c9orf72), [TDP-43](/mechanisms/tdp-43-proteinopathy), and neuroprotection.

Frontotemporal Dementia (FTD)

38 ideas for tau, progranulin, and TDP-43 pathology.

Innovation Metrics

Novelty Scores

| Score Range | Ideas |
|-------------|-------|
| 8-10 (Highly Novel) | 22 |
| 5-7 (Moderately Novel) | 48 |
| 2-4 (Incremental) | 33 |

Delivery Feasibility

| Approach | Feasibility |
|----------|-------------|
| Peripheral delivery | High |
| AAV gene therapy | Moderate |
| Brain-penetrant small molecules | High |
| Antibody (peripheral) | Moderate |
| Intranasal | High |

Pipeline Gaps

Underserved Mechanisms

• Tau secretion blocking — Limited approaches
• [Microglia](/cell-types/microglia-neuroinflammation) metabolic reprogramming — Emerging area
• Neuronal proteostasis enhancement — High potential
• [Blood-brain barrier](/entities/blood-brain-barrier) modulation — Technical challenges

Underserved Diseases

• Multiple System Atrophy (MSA) — Few ideas
• Progressive Supranuclear Palsy (PSP) — Limited coverage
• Corticobasal Degeneration (CBD) — Minimal ideas

Related Pages

• [Ideas Index](/ideas) — Full ideas directory
• [Ideas Overview](/ideas/overview) — Methodology
• [Ideas Rankings](/ideas/rankings) — Ranked list

See Also

• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/)
• [KEGG Pathways](https://www.genome.jp/kegg/pathway.html)

References