NeuroWiki Work Queue

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project2025 wordssynced 2026-04-02

Overview

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NeuroWiki Work Queue is a topic within the NeuroWiki knowledge base covering aspects of neurodegenerative disease research and mechanisms.

Last Updated: 2026-03-21 08:04 PT

Total Open Tasks: 74

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Overview

Mermaid diagram (expand to render)

NeuroWiki Work Queue is a topic within the NeuroWiki knowledge base covering aspects of neurodegenerative disease research and mechanisms.

Last Updated: 2026-03-21 08:04 PT

Total Open Tasks: 74

Open Tasks (Ranked by Priority)

| Priority | Type | Title | Spec |
|----------|------|-------|------|
| P0 | CI | Pull recent publications | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Deepen existing pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Expand wiki coverage | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Quest for Cures — therapeutic ideas pipeline | [View](/docs/planning/specs/quest_cures_spec) |
| P0 | CI | Quest: Knowledge Graph Density — cross-link and connect | [View](/docs/planning/specs/quest_graph_spec) |
| P0 | CI | Quest: Evidence Depth — deepen thin pages to 3000+ words | [View](/docs/planning/specs/quest_depth_spec) |
| P0 | CI | Quest: Emerging Research — track cutting-edge discoveries | [View](/docs/planning/specs/quest_emerging_spec) |
| P0 | CI | Quest: Conference Intelligence — crawl and capture conference content | [View](/docs/planning/specs/quest_conferences_spec) |
| P0 | CI | Quest AD: Mechanisms — map all Alzheimer's molecular pathways | [View](/docs/planning/specs/quest_ad_mech_spec) |
| P0 | CI | Quest AD: Clinical Trials — track all AD therapeutic trials | [View](/docs/planning/specs/quest_ad_trials_spec) |
| P0 | CI | Quest PD: Mechanisms — map all Parkinson's molecular pathways | [View](/docs/planning/specs/quest_pd_mech_spec) |
| P0 | CI | Quest PD: Clinical Trials — track all PD therapeutic trials | [View](/docs/planning/specs/quest_pd_trials_spec) |
| P0 | CI | Quest CBS: Mechanisms — map corticobasal degeneration pathways | [View](/docs/planning/specs/quest_cbs_mech_spec) |
| P0 | CI | Quest PSP: Mechanisms — map PSP molecular pathways | [View](/docs/planning/specs/quest_psp_mech_spec) |
| P0 | CI | Run wiki quality review | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Fix top loss maker | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Fix page corruption | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Strategic task planning | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P0 | CI | Quest: Mechanistic Models — build pathway and interaction maps | [View](/docs/planning/specs/quest_mechanisms_spec) |
| P0 | CI | Quest: Clinical Translation — bridge bench to bedside | [View](/docs/planning/specs/quest_clinical_spec) |
| P0 | CI | Quest: Experiment Design — generate, cost, and rank experiments | [View](/docs/planning/specs/quest_experiments_spec) |
| P0 | CI | Quest: Living Index Pages — keep rankings and indexes current | [View](/docs/planning/specs/quest_indexes_spec) |
| P0 | CI | Quest AD: Companies & Organizations — track AD therapeutic landscape | [View](/docs/planning/specs/quest_ad_companies_spec) |
| P0 | CI | Quest AD: Hypotheses & Evidence — generate and rank AD hypotheses | [View](/docs/planning/specs/quest_ad_hypotheses_spec) |
| P0 | CI | Quest PD: Companies — track PD therapeutic landscape | [View](/docs/planning/specs/quest_pd_companies_spec) |
| P0 | CI | Quest PD: Hypotheses — generate and rank PD hypotheses | [View](/docs/planning/specs/quest_pd_hypotheses_spec) |
| P0 | CI | Quest CBS: Clinical Trials & Treatments — track CBS therapeutic efforts | [View](/docs/planning/specs/quest_cbs_trials_spec) |
| P0 | CI | Quest CBS: Evidence Synthesis — deepen CBS understanding | [View](/docs/planning/specs/quest_cbs_evidence_spec) |
| P0 | CI | Quest PSP: Clinical Trials — track PSP therapeutic pipeline | [View](/docs/planning/specs/quest_psp_trials_spec) |
| P0 | CI | Quest PSP: Evidence Synthesis — comprehensive PSP knowledge | [View](/docs/planning/specs/quest_psp_evidence_spec) |
| P0 | CI | Quest 4R-Tauopathies: Shared [Tau](/proteins/tau) Biology — CBS/PSP/other 4R-tau diseases | [View](/docs/planning/specs/quest_4rt_tau_spec) |
| P0 | CI | Quest PSP: Gender Differences in PSP - male apathy phenotype | [View](/docs/planning/specs/b06c2b87_608_spec) |
| P1 | CI | Run entity linker | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Fix page queue | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Link entities to Allen Brain Atlas | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Improve cross-linking | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Deduplicate wiki pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Quest: Disease Comparisons — map shared and unique mechanisms | [View](/docs/planning/specs/quest_compare_spec) |
| P1 | CI | Quest: Entity Discovery — systematically find and create missing pages | [View](/docs/planning/specs/quest_entities_spec) |
| P1 | CI | Quest AD: Biomarkers — track diagnostic and prognostic markers | [View](/docs/planning/specs/quest_ad_biomarkers_spec) |
| P1 | CI | Quest PD: Technologies — track PD-specific therapeutic technologies | [View](/docs/planning/specs/quest_pd_technologies_spec) |
| P1 | CI | Quest CBS: Diagnostics — track CBS/CBD diagnostic advances | [View](/docs/planning/specs/quest_cbs_dx_spec) |
| P1 | CI | Quest PSP: Research Community — track PSP researchers, orgs, funding | [View](/docs/planning/specs/quest_psp_community_spec) |
| P1 | CI | Quest: Shared Therapeutic Targets — identify cross-disease opportunities | [View](/docs/planning/specs/quest_shared_targets_spec) |
| P1 | CI | Create gene pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Create protein pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | CI: Smart task prioritizer — rank queue with explore/exploit | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | CI: Entity tracker — systematic company and technology coverage | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | CI: Page quality ranker — score and rank all wiki pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | CI: Section health monitor — track per-section quality metrics | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Review and update research gaps | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P1 | CI | Create Korean PD Biotech Company Pages | [View](/docs/planning/specs/2add8264_969_spec) |
| P1 | CI | Create Digital Health PD Wearables Pages | [View](/docs/planning/specs/69f7cd4d_6ea_spec) |
| P2 | CI | Update with recent publications | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Fix broken links | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Scan and queue issues | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | One-shot | Deep dive: Anti-tau immunotherapy programs | [View](/docs/planning/specs/ebc54366_5f6_spec) |
| P2 | One-shot | Deep dive: AAV gene therapy for Parkinson's | [View](/docs/planning/specs/89e2384a_fa6_spec) |
| P2 | One-shot | Deep dive: ASO therapies for tau reduction | [View](/docs/planning/specs/d6db8d20_1a4_spec) |
| P2 | One-shot | Process page suggestions | [View](/docs/planning/specs/2405d8bf_a9a_spec) |
| P2 | CI | Update All Pages index | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Proofread pages for formatting | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Verify navigation & index pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Update R&D investment landscape | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Therapy invention freshness | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Knowledge gap freshness | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | CI | Cell type atlas freshness | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P2 | One-shot | CI: Update Work Queue Dashboard | [View](/docs/planning/specs/ef3d2efe_d60_spec) |
| P3 | CI | Task queue and wiki health check | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P3 | One-shot | Update Work Queue Dashboard | [View](/docs/planning/specs/fc5c3df0_b49_spec) |
| P3 | CI | Create researcher pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P3 | CI | Create institution pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P3 | CI | Expand short researcher pages | [View](/docs/planning/specs/ci001_quality_review_spec) |
| P3 | One-shot | Create biomarker page: Skin Biopsy Tau Seeding in CBS/PSP | [View](/docs/planning/specs/3b93a75f_112_spec) |

Task Details

Pull recent publications

ID: `018259fd-7803-4832-b139-9eccd6281ce8`
Priority: P0 (100)
Type: recurring
Created: 2026-03-20 11:20 PT
Frequency: every-6h
Spec: docs/planning/specs/ci001_quality_review_spec

Description: Pull recent publications from neuroscience researchers and update relevant wiki pages.

Deepen existing pages

ID: `d3cf8645-42bc-4028-b93e-96e0c986e768`
Priority: P0 (100)
Type: recurring
Created: 2026-03-20 11:20 PT
Frequency: every-6h
Spec: docs/planning/specs/ci001_quality_review_spec

Description: Deepen existing pages - PRIORITY. Focus on pages <500 words, especially core proteins. Target 2000+ words per page.

Expand wiki coverage

ID: `6578c64f-ae02-4f98-9d6b-a1e38ef6978f`
Priority: P0 (95)
Type: recurring
Created: 2026-03-20 11:20 PT
Frequency: every-6h
Spec: docs/planning/specs/ci001_quality_review_spec

Description: Daily bot evolution cycle. Last run: 2026-03-20 05:18 PT - +$734.08 PnL (1736 trades, 120 bots), promotion gate OPEN, drift PASS

Quest for Cures — therapeutic ideas pipeline

ID: `7d6670f6-149c-49f6-8f22-4ef6dae730d9`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 10:40 PT
Frequency: every-6h
Spec: docs/planning/specs/quest_cures_spec

Description: Maintain 100+ ranked therapeutic hypotheses for neurodegeneration. Each cycle: review existing ideas, identify gaps, CREATE 1-2 new therapeutic idea pages via wiki API with 10-dimension rubric scoring. Must create at least 1 new orchestra task per cycle. Spec: docs/planning/specs/quest_cures_therapeutic_ideas

Quest: Knowledge Graph Density — cross-link and connect

ID: `0de87bd7-a95c-4724-a118-45559558bb94`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 10:45 PT
Frequency: every-6h
Spec: docs/planning/specs/quest_graph_spec

Description: Increase wiki knowledge graph density. Each cycle: find 5 poorly-connected pages (few inbound/outbound links), add cross-links, create missing entity pages, link to related pathways/diseases/proteins. Must CREATE 1-2 new tasks for pages that need creation or deep expansion. Use entity_linker.py to find gaps. Target: every page should have 10+ outbound links.

Quest: Evidence Depth — deepen thin pages to 3000+ words

ID: `d8a13fc8-452c-4004-b40b-59b4b28bdbe5`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 10:45 PT
Frequency: every-6h
Spec: docs/planning/specs/quest_depth_spec

Description: Find and deepen the thinnest wiki pages. Each cycle: query wiki for pages under 1000 words in key sections (entities/, mechanisms/, diseases/), pick the 1-2 most important ones, expand to 3000+ words with 20+ PubMed references. Must CREATE 1 task for the next batch of thin pages to expand. Track progress in spec.

Quest: Emerging Research — track cutting-edge discoveries

ID: `e221bc13-f395-45cd-ba76-161632c3c771`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 10:45 PT
Frequency: every-6h
Spec: docs/planning/specs/quest_emerging_spec

Description: Systematically track emerging research in neurodegeneration from multiple sources. Each cycle: (1) Crawl Alzforum (alzforum.org) news, research news, therapeutics database for new findings. (2) Check recent high-impact publications on PubMed (2024-2026). (3) Track conference proceedings (AD/PD, AAIC, SfN, CTAD) for new abstracts, posters, talks. (4) Identify novel targets, mechanisms, biomarkers, therapeutic approaches not yet in wiki. (5) CREATE 2-3 new tasks: pages for new discoveries, conference coverage, company/org updates. Use WebFetch to crawl sources. Create pages under appropriate sections (entities/, mechanisms/, treatments/, etc.) with dense cross-linking.

Quest: Conference Intelligence — crawl and capture conference content

ID: `197f9303-cfcd-4045-b902-5a4dca1c6037`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 11:05 PT
Frequency: daily
Spec: docs/planning/specs/quest_conferences_spec

Description: Systematically crawl major neurodegeneration conferences and capture all content in the wiki. Target conferences: AD/PD (adpd.kenes.com), AAIC (aaic.alz.org), CTAD (ctad-alzheimer.com), SfN Annual Meeting, AAN Annual Meeting, World Parkinson Congress, International Congress on Parkinson's Disease. Each cycle: (1) WebFetch conference websites for programs, abstracts, poster listings, speaker lists, sponsor/exhibitor lists. (2) Create/update pages under events/{conference-slug}/ for each conference. (3) Create pages for notable talks, poster highlights, key findings. (4) Create/update pages for companies and organizations presenting. (5) Cross-link to existing mechanism/disease/treatment pages. (6) CREATE 2-3 tasks for specific conference content to capture. Track all conferences in an events/conference-index page.

Quest AD: Mechanisms — map all Alzheimer's molecular pathways

ID: `3a885889-6c19-4103-8e31-1582eb34a828`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 11:15 PT
Frequency: every-6h
Spec: docs/planning/specs/quest_ad_mech_spec

Description: Systematically map ALL Alzheimer's molecular pathways with zero bias toward any single hypothesis. Each cycle: (1) Query wiki for AD mechanism pages, rank by completeness (word count, refs, cross-links). (2) Identify the LEAST covered mechanism — not the most popular one. (3) WebSearch PubMed for recent reviews on that mechanism to ensure coverage reflects current evidence weight, not historical prominence. (4) CREATE 2-3 tasks to fill gaps. IMPORTANT: Do NOT fixate on amyloid/tau — equally cover lipid metabolism, vascular, immune, metabolic, infectious, epigenetic, RNA, proteostasis, and any novel hypotheses. The ranking page should weight mechanisms by: number of supporting publications, clinical trial activity, genetic evidence strength, and recency of discoveries. Maintain mechanisms/ad-mechanism-index with evidence-weighted rankings.

Quest AD: Clinical Trials — track all AD therapeutic trials

ID: `deecb135-3702-4246-b05f-c17e29b429f5`
Priority: P0 (95)
Type: recurring
Created: 2026-03-21 11:15 PT
Frequency: daily
Spec: docs/planning/specs/quest_ad_trials_spec

Description: Track ALL active AD clinical trials without bias toward any mechanism or company. Each cycle: (1) WebFetch clinicaltrials.gov searching 'Alzheimer' — include recruiting, active, and recently completed. (2) Categorize by mechanism class — do NOT pre-filter. Include: novel mechanisms, repurposed drugs, combinations, non-pharmacological, biomarker studies, prevention, lifestyle interventions. (3) Identify trials NOT yet in wiki — prioritize by phase, enrollment, and novelty of approach over company prominence. (4) CREATE 2-3 tasks. Rank trials by evidence strength and potential impact, not sponsor size.
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External Links

[PubMed](https://pubmed.ncbi.nlm.nih.gov/)
[KEGG Pathways](https://www.genome.jp/kegg/pathway.html)

References

NeuroWiki Contributors, NeuroWiki: A Mechanistic Wiki for Neurodegenerative Diseases (2026)

📖 View canonical wiki page →

NeuroWiki Work Queue

Overview

Overview

Open Tasks (Ranked by Priority)

Task Details

Pull recent publications

Deepen existing pages

Expand wiki coverage

Quest for Cures — therapeutic ideas pipeline

Quest: Knowledge Graph Density — cross-link and connect

Quest: Evidence Depth — deepen thin pages to 3000+ words

Quest: Emerging Research — track cutting-edge discoveries

Quest: Conference Intelligence — crawl and capture conference content

Quest AD: Mechanisms — map all Alzheimer's molecular pathways

Quest AD: Clinical Trials — track all AD therapeutic trials

See Also

External Links

References