Adra2B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein">
| Attribute | Value | |-----------|-------| | Protein Name | ADRA2B, Alpha-2B Adrenergic Receptor | | Gene Symbol | [adra2b](/proteins/adra2b-protein) | | UniProt ID | [P47820](https://www.uniprot.org/uniprot/P47820) | | Molecular Weight | ~50-60 kDa | | Subcellular Localization | Cell membrane | | Protein Family | Class A GPCR, α2-adrenergic family | | Ligand | Norepinephrine, epinephrine, clonidine | | Signal Transduction | Gi/o protein, ↓cAMP |
</div>}
Overview
The Alpha-2B Adrenergic Receptor (ADRA2B) is an inhibitory G protein-coupled receptor that regulates sympathetic tone, cardiovascular function, and central nervous system activity. It belongs to the α2-adrenergic receptor subfamily (ADRA2A, ADRA2B, ADRA2C) and is characterized by its Gi/o protein-coupled inhibition of adenylate cyclase, reducing intracellular cAMP levels.
Structure
ADRA2B has the typical seven-transmembrane GPCR structure:
Transmembrane Domain
Seven α-helices: Canonical GPCR fold
Conserved motifs: For ligand binding (asparagine in TM7)
Orthosteric site: Binds catecholamines and imidazoles
Extracellular Domain
N-terminal tail: Short extracellular sequence
Glycosylation sites: N-linked glycosylation
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adra2b Protein
Introduction
Adra2B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein">
| Attribute | Value | |-----------|-------| | Protein Name | ADRA2B, Alpha-2B Adrenergic Receptor | | Gene Symbol | [adra2b](/proteins/adra2b-protein) | | UniProt ID | [P47820](https://www.uniprot.org/uniprot/P47820) | | Molecular Weight | ~50-60 kDa | | Subcellular Localization | Cell membrane | | Protein Family | Class A GPCR, α2-adrenergic family | | Ligand | Norepinephrine, epinephrine, clonidine | | Signal Transduction | Gi/o protein, ↓cAMP |
</div>}
Overview
The Alpha-2B Adrenergic Receptor (ADRA2B) is an inhibitory G protein-coupled receptor that regulates sympathetic tone, cardiovascular function, and central nervous system activity. It belongs to the α2-adrenergic receptor subfamily (ADRA2A, ADRA2B, ADRA2C) and is characterized by its Gi/o protein-coupled inhibition of adenylate cyclase, reducing intracellular cAMP levels.
Structure
ADRA2B has the typical seven-transmembrane GPCR structure:
Transmembrane Domain
Seven α-helices: Canonical GPCR fold
Conserved motifs: For ligand binding (asparagine in TM7)
Orthosteric site: Binds catecholamines and imidazoles
Extracellular Domain
N-terminal tail: Short extracellular sequence
Glycosylation sites: N-linked glycosylation
Intracellular Domain
C-terminal tail: Phosphorylation sites for desensitization
G protein coupling domain: Gi/o protein specificity
| Drug Class | Example | Clinical Use | |------------|---------|--------------| | Agonists | Clonidine, guanfacine | Hypertension, ADHD | | Antagonists | Atipamezole | Veterinary reversal | | Selective agonists | Brimonidine | Glaucoma |
Clinical Applications
Hypertension: Clonidine, guanfacine
ADHD: Guanfacine (Intuniv)
Opioid withdrawal: Clonidine
Glaucoma: Brimonidine
Background
The study of Adra2B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.