Anxa1 Protein — Annexin A1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> <span class="infobox-title">ANXA1 Protein</span> | Property | Value | |----------|-------| | Protein Name | Annexin A1 (Lipocortin-1) | | Gene Symbol | ANXA1 | | UniProt ID | P04083 | | Molecular Weight | ~37 kDa | | Cellular Localization | Cytoplasm, Cell Membrane, Extracellular | | Protein Family | Annexin Family | | Structure | 4 Annexin Repeats, N-terminal Region | </div>
Overview
ANXA1 (Annexin A1), also known as lipocortin-1, is a calcium-dependent phospholipid-binding protein that belongs to the annexin family. Originally discovered as a glucocorticoid-induced protein with potent anti-inflammatory properties, Annexin A1 is now recognized as a multifunctional protein with roles in neuroprotection, neuroinflammation modulation, and synaptic plasticity. Its expression in neurons and glial cells makes it a key player in neurodegenerative disease pathogenesis.
Structure
Annexin A1 contains:
N-terminal Region: Unique sequence, contains phosphorylation sites and interaction domains
Four Annexin Repeats: Conserved calcium-dependent phospholipid-binding domains
Calcium-Binding Sites: EF-hand motifs in each repeat
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ANXA1 Protein — Annexin A1
Introduction
Anxa1 Protein — Annexin A1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> <span class="infobox-title">ANXA1 Protein</span> | Property | Value | |----------|-------| | Protein Name | Annexin A1 (Lipocortin-1) | | Gene Symbol | ANXA1 | | UniProt ID | P04083 | | Molecular Weight | ~37 kDa | | Cellular Localization | Cytoplasm, Cell Membrane, Extracellular | | Protein Family | Annexin Family | | Structure | 4 Annexin Repeats, N-terminal Region | </div>
Overview
ANXA1 (Annexin A1), also known as lipocortin-1, is a calcium-dependent phospholipid-binding protein that belongs to the annexin family. Originally discovered as a glucocorticoid-induced protein with potent anti-inflammatory properties, Annexin A1 is now recognized as a multifunctional protein with roles in neuroprotection, neuroinflammation modulation, and synaptic plasticity. Its expression in neurons and glial cells makes it a key player in neurodegenerative disease pathogenesis.
Structure
Annexin A1 contains:
N-terminal Region: Unique sequence, contains phosphorylation sites and interaction domains
Four Annexin Repeats: Conserved calcium-dependent phospholipid-binding domains
[Protein Data Bank: ANXA1](https://www.rcsb.org/structure/1AIN)
Background
The study of Anxa1 Protein — Annexin A1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.