Anxa2 Protein — Annexin A2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> <span class="infobox-title">ANXA2 Protein</span> | Property | Value | |----------|-------| | Protein Name | Annexin A2 (p36) | | Gene Symbol | ANXA2 | | UniProt ID | P07355 | | Molecular Weight | ~36 kDa | | Subcellular Location | Cytoplasm, Plasma membrane, Nucleus | | Protein Family | Annexin family | | Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer, Acute Myeloid Leukemia | </div>
Overview
ANXA2 (Annexin A2) is a calcium-dependent phospholipid-binding protein that participates in various cellular processes including membrane organization, endocytosis, and signal transduction. ANXA2 exists as both a monomer and heterotetramer with S100A10, and has been implicated in neurodegeneration and cancer[@gerke2022].
Anxa2 Protein — Annexin A2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> <span class="infobox-title">ANXA2 Protein</span> | Property | Value | |----------|-------| | Protein Name | Annexin A2 (p36) | | Gene Symbol | ANXA2 | | UniProt ID | P07355 | | Molecular Weight | ~36 kDa | | Subcellular Location | Cytoplasm, Plasma membrane, Nucleus | | Protein Family | Annexin family | | Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer, Acute Myeloid Leukemia | </div>
Overview
ANXA2 (Annexin A2) is a calcium-dependent phospholipid-binding protein that participates in various cellular processes including membrane organization, endocytosis, and signal transduction. ANXA2 exists as both a monomer and heterotetramer with S100A10, and has been implicated in neurodegeneration and cancer[@gerke2022].
| Strategy | Approach | Status | Notes | |----------|----------|--------|-------| | ANXA2 Inhibitors | Cancer therapy | Research | Cytotoxicity | | Antibodies | Diagnostic | Research | Biomarker | | Peptides | Therapy | Research | Disrupt function |
Animal Models
Knockout Mice
Anxa2 knockout mice show:
Embryonic lethality (some backgrounds)
Endothelial abnormalities
Impaired endocytosis
Transgenic Models
Overexpression in tumors
Neurological models
Background
The study of Anxa2 Protein — Annexin A2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.