CHD5 (Chromodomain Helicase DNA-Binding Protein 5) is a neuron-specific ATP-dependent chromatin remodeler that functions as a potent transcriptional activator. CHD5 is expressed primarily in neuronal tissue where it regulates genes essential for neural development, synaptic plasticity, and cognitive function. As a tumor suppressor, CHD5 is frequently deleted in neuroblastoma and its dysfunction has been linked to neurodegenerative diseases. [@hu2020]
Overview
CHD5 protein is the neuron-specific member of the CHD family, distinguished by its restricted expression pattern and transcriptional activation function. Unlike other CHD proteins that primarily repress transcription, CHD5 activates neuronal gene expression programs through chromatin remodeling and recruitment of histone modifiers. CHD5 is essential for memory formation and its dysfunction contributes to cognitive decline in aging and disease. [@dalessio2018]
<div class="infobox infobox-protein">
| Property | Value | |----------|-------| | Protein Name | CHD5 | | Gene | CHD5 | | UniProt ID | Q8TDC0 | | PDB ID | 5MLM | | Molecular Weight | 260 kDa | | Subcellular Localization | Nucleus (chromatin-associated) | | Protein Family | CHD family, SNF2 superfamily | | Aliases | CHD5, NEDE, KIAA1731 |
</div>
Structure
CHD5 protein contains characteristic CHD family domains:
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title: CHD5 Protein
CHD5 Protein
Introduction
CHD5 (Chromodomain Helicase DNA-Binding Protein 5) is a neuron-specific ATP-dependent chromatin remodeler that functions as a potent transcriptional activator. CHD5 is expressed primarily in neuronal tissue where it regulates genes essential for neural development, synaptic plasticity, and cognitive function. As a tumor suppressor, CHD5 is frequently deleted in neuroblastoma and its dysfunction has been linked to neurodegenerative diseases. [@hu2020]
Overview
CHD5 protein is the neuron-specific member of the CHD family, distinguished by its restricted expression pattern and transcriptional activation function. Unlike other CHD proteins that primarily repress transcription, CHD5 activates neuronal gene expression programs through chromatin remodeling and recruitment of histone modifiers. CHD5 is essential for memory formation and its dysfunction contributes to cognitive decline in aging and disease. [@dalessio2018]
<div class="infobox infobox-protein">
| Property | Value | |----------|-------| | Protein Name | CHD5 | | Gene | CHD5 | | UniProt ID | Q8TDC0 | | PDB ID | 5MLM | | Molecular Weight | 260 kDa | | Subcellular Localization | Nucleus (chromatin-associated) | | Protein Family | CHD family, SNF2 superfamily | | Aliases | CHD5, NEDE, KIAA1731 |
</div>
Structure
CHD5 protein contains characteristic CHD family domains:
Tandem chromodomains - Bind methylated histone tails (H3K4me3, H3K9me3)
SNF2-type ATPase domain - Catalytic center for chromatin remodeling
DNA-binding domains - Two SANT domains for nucleosome interaction
C-terminal region - Protein interaction motifs
Normal Function
CHD5 in [neurons](/entities/neurons):
Transcriptional activation - Potent activator of neuronal genes