Cln3 Protein (Battenin) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{- <!-- CLN3 Protein Page - Ceroid Lipofuscinosis, Neuronal 3 Protein --> -}} [@johnson2023]
| Attribute | Value | [@storch2008] |-----------|-------| | Protein Name | Battenin | | Gene | CLN3 | | UniProt ID | Q9UQ16 | | PDB Structure | No structure available | | Molecular Weight | 48 kDa | | Subcellular Localization | Lysosomal membrane, Endosomal membrane | | Protein Family | CLN3 family, transmembrane proteins |
</div>}
Overview
CLN3 protein (also known as Battenin) is a lysosomal and endosomal transmembrane protein encoded by the CLN3 gene. It plays a critical role in maintaining lysosomal function, [autophagy](/entities/autophagy), and neuronal survival. Mutations in the CLN3 gene cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Batten disease<sup>[1]</sup>.
Structure
Primary Structure
CLN3 is a 438-amino acid integral membrane protein with the following features:
Large luminal loop: Contains potential N-linked glycosylation sites
Topology
...
CLN3 Protein (Battenin)
Introduction
Cln3 Protein (Battenin) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
{{- <!-- CLN3 Protein Page - Ceroid Lipofuscinosis, Neuronal 3 Protein --> -}} [@johnson2023]
| Attribute | Value | [@storch2008] |-----------|-------| | Protein Name | Battenin | | Gene | CLN3 | | UniProt ID | Q9UQ16 | | PDB Structure | No structure available | | Molecular Weight | 48 kDa | | Subcellular Localization | Lysosomal membrane, Endosomal membrane | | Protein Family | CLN3 family, transmembrane proteins |
</div>}
Overview
CLN3 protein (also known as Battenin) is a lysosomal and endosomal transmembrane protein encoded by the CLN3 gene. It plays a critical role in maintaining lysosomal function, [autophagy](/entities/autophagy), and neuronal survival. Mutations in the CLN3 gene cause Juvenile Neuronal Ceroid Lipofuscinosis (JNCL), also known as Batten disease<sup>[1]</sup>.
Structure
Primary Structure
CLN3 is a 438-amino acid integral membrane protein with the following features:
The study of Cln3 Protein (Battenin) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.