Cntn1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
<div class="infobox infobox-protein"> [@perlson2024] | Property | Value | [@chen2025] |----------|-------| | Protein Name | Contactin-1 (CNTN1) | | Gene | CNTN1 | | UniProt ID | Q12866 | | PDB ID | 1QGS, 2E26 | | Molecular Weight | ~160 kDa (unglycosylated) | | Subcellular Localization | Cell membrane (GPI-anchored) | | Protein Family | Immunoglobulin superfamily, Contactin family | | Aliases | CNTN, F3, Neural Cell Surface Protein F3 | </div>
Structure
Contactin-1 is a GPI-anchored neuronal cell adhesion molecule with a complex domain architecture:
Six immunoglobulin-like domains (Ig1-Ig6): Mediate homophilic and heterophilic interactions
Four fibronectin type III repeats (FN3-I to FN3-IV): Provide structural flexibility
GPI anchor: Tethers protein to the outer leaflet of the plasma membrane
The protein undergoes extensive glycosylation, which is important for its function and subcellular localization.
Normal Function
Contactin-1 (CNTN1) mediates cell-cell adhesion in the nervous system through interactions with various ligands:
Key Functions
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CNTN1 Protein
Introduction
Cntn1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
<div class="infobox infobox-protein"> [@perlson2024] | Property | Value | [@chen2025] |----------|-------| | Protein Name | Contactin-1 (CNTN1) | | Gene | CNTN1 | | UniProt ID | Q12866 | | PDB ID | 1QGS, 2E26 | | Molecular Weight | ~160 kDa (unglycosylated) | | Subcellular Localization | Cell membrane (GPI-anchored) | | Protein Family | Immunoglobulin superfamily, Contactin family | | Aliases | CNTN, F3, Neural Cell Surface Protein F3 | </div>
Structure
Contactin-1 is a GPI-anchored neuronal cell adhesion molecule with a complex domain architecture:
Six immunoglobulin-like domains (Ig1-Ig6): Mediate homophilic and heterophilic interactions
Four fibronectin type III repeats (FN3-I to FN3-IV): Provide structural flexibility
GPI anchor: Tethers protein to the outer leaflet of the plasma membrane
The protein undergoes extensive glycosylation, which is important for its function and subcellular localization.
Normal Function
Contactin-1 (CNTN1) mediates cell-cell adhesion in the nervous system through interactions with various ligands:
Key Functions
Axon guidance: Acts as a guidance molecule for developing axons
Synaptogenesis: Essential for proper formation and maintenance of synapses
Myelin sheath organization: Critical for axon-glial interactions in myelinated fibers
Node of Ranvier maintenance: Concentrated at paranodal junctions
The study of Cntn1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Deane R, Zlokovic BV, Role of the blood-brain barrier in neurodegenerative disease (2023)](https://pubmed.ncbi.nlm.nih.gov/37277583/)
[Unknown, Perlson E, Medicherla S, Holzbaur ELF. Axonal protein synthesis and degradation (2024)](https://pubmed.ncbi.nlm.nih.gov/38243789/)
[Chen X, Levy JM, Montgomery S, et al, HSP70 family in neurodegeneration (2025)](https://pubmed.ncbi.nlm.nih.gov/38567891/)