Dnmt1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DNA Methyltransferase 1 (DNMT1) is the primary maintenance DNA methyltransferase responsible for copying [DNA methylation](/entities/dna-methylation) patterns during DNA replication[@robertson1999]. It catalyzes the addition of methyl groups to cytosine residues in CpG dinucleotides, playing essential roles in genomic imprinting, X-chromosome inactivation, and cellular differentiation. DNMT1 dysfunction is implicated in Alzheimer's disease, Parkinson's disease, and various cancers[@esteller2002].
Dnmt1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
DNA Methyltransferase 1 (DNMT1) is the primary maintenance DNA methyltransferase responsible for copying [DNA methylation](/entities/dna-methylation) patterns during DNA replication[@robertson1999]. It catalyzes the addition of methyl groups to cytosine residues in CpG dinucleotides, playing essential roles in genomic imprinting, X-chromosome inactivation, and cellular differentiation. DNMT1 dysfunction is implicated in Alzheimer's disease, Parkinson's disease, and various cancers[@esteller2002].
<div class="infobox infobox-protein">
<table>
<tr><th colspan="2" style="background:#f0f0f0;">DNMT1 Protein</th></tr>
<tr><td><strong>Protein Name</strong></td><td>DNA Methyltransferase 1</td></tr>
<tr><td><strong>Gene</strong></td><td>[DNMT1](/genes/dnmt1)</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[P26358](https://www.uniprot.org/uniprot/P26358)</td></tr>
<tr><td><strong>PDB ID(s)</strong></td><td>3AV0, 4WXX</td></tr>
<tr><td><strong>Molecular Weight</strong></td><td>183 kDa</td></tr>
<tr><td><strong>Subcellular Localization</strong></td><td>Nucleus</td></tr>
<tr><td><strong>Protein Family</strong></td><td>DNA methyltransferase family</td></tr>
<tr><td><strong>Expression</strong></td><td>Ubiquitous, high in proliferating cells</td></tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/aging" style="color:#ef9a9a">Aging</a>, <a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/amyotrophic-lateral-sclerosis" style="color:#ef9a9a">Amyotrophic Lateral Sclerosis</a>, <a href="/wiki/ataxia" style="color:#ef9a9a">Ataxia</a></td>
</tr>
<tr>
<td class="label">SciDEX Hypotheses</td>
<td><a href="/hypothesis/h-782e55f6" style="color:#ce93d8" title="Score: 0.35">DNMT1-Targeting Antisense Oligonucleotid...</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">246 edges</a></td>
</tr>
</table>
</div>
DNMT1 contains multiple functional domains[@syeda2011]:
DNMT1 alterations in AD include[@chouliaras2013]:
| Drug | Type | Approval | Indication |
|------|------|----------|------------|
| Azacitidine | Nucleoside analog | 2004 | MDS, AML |
| Decitabine | Nucleoside analog | 2006 | MDS, AML |
| Guadecitabine | Second-generation | Clinical trials | Various |
The study of Dnmt1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
From the [SciDEX Exchange](/exchange) — scored by multi-agent debate