Dishevelled 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@dvl2018] title: Dishevelled 1 Protein [@dishevelled2020] --- [@dvl2019]
<div class="infobox infobox-protein"> [@wnt2017]
| | | [@dishevelled2021] |---|---| [@dvl2020] | Protein Name | Dishevelled 1 | [@targeting2022] | Gene | [DVL1](/genes/dvl1) | | UniProt ID | [Q92997](https://www.uniprot.org/uniprot/Q92997) | | PDB ID | 1L6O, 2KDQ, 3C5G, 4WJI, 4WJJ, 4WJK | | Molecular Weight | 70-80 kDa (alternatively spliced) | | Subcellular Localization | Cytoplasm, Cell membrane, Synapses | | Protein Family | Dishevelled family |
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Overview
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Dishevelled 1 Protein
Introduction
Dishevelled 1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
--- [@dvl2018] title: Dishevelled 1 Protein [@dishevelled2020] --- [@dvl2019]
<div class="infobox infobox-protein"> [@wnt2017]
| | | [@dishevelled2021] |---|---| [@dvl2020] | Protein Name | Dishevelled 1 | [@targeting2022] | Gene | [DVL1](/genes/dvl1) | | UniProt ID | [Q92997](https://www.uniprot.org/uniprot/Q92997) | | PDB ID | 1L6O, 2KDQ, 3C5G, 4WJI, 4WJJ, 4WJK | | Molecular Weight | 70-80 kDa (alternatively spliced) | | Subcellular Localization | Cytoplasm, Cell membrane, Synapses | | Protein Family | Dishevelled family |
</div>
Overview
Mermaid diagram (expand to render)
Dishevelled 1 (DVL1) is a key scaffolding protein in the Wnt signaling pathway. It is a cytoplasmic protein that transduces Wnt signals from Frizzled receptors to downstream effectors, playing essential roles in development and neuronal function.
Structure
Size: 670 amino acids (canonical isoform)
Molecular weight: ~70-80 kDa
Domains:
DAX domain (N-terminal): Mediates dimerization and interactions
PDZ domain: Protein-protein interactions
DEP domain (C-terminal): Membrane targeting and signal transduction
Isoforms: Multiple isoforms due to alternative splicing
Function
Wnt signal transduction: Central mediator of canonical and non-canonical Wnt signaling
Canonical pathway: Inhibits β-catenin destruction complex, leading to β-catenin stabilization
Non-canonical pathways: Mediates planar cell polarity (PCP) and Wnt/Ca²⁺ signaling
The study of Dishevelled 1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.