EAAT4 Protein (Excitatory Amino Acid Transporter 4)
📖 Wiki Page
protein651 wordssynced 2026-04-02
EAAT4 Protein (Excitatory Amino Acid Transporter 4)
Overview
Eaat4 Protein (Excitatory Amino Acid Transporter 4) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications. PMID: 17182680
Introduction
Eaat4 Protein (Excitatory Amino Acid Transporter 4) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@ref1992]
<div class="infobox infobox-protein"> [@ref1994a]
EAAT4 [@ref2001]
| | | |---|---| | Protein Name | EAAT4 | | Gene | [SLC1A6](/genes/slc1a6) | | UniProt ID | [P22732](https://www.uniprot.org/uniprot/P22732) | | Molecular Weight | ~65 kDa | | Subcellular Localization | Plasma membrane (neurons) | | Protein Family | SLC1 (EAAT) family | | Associated Diseases | [Epilepsy](/diseases/epilepsy), [Ataxia](/diseases/ataxia), [Neurodegeneration](/diseases/neurodegeneration) |
</div>
Structure
EAAT4 is a transmembrane protein with:
Eight transmembrane domains
A reentrant loop between transmembrane domains 7 and 8
Intracellular N- and C-termini
Glycosylation sites in extracellular loops
...
EAAT4 Protein (Excitatory Amino Acid Transporter 4)
Overview
Eaat4 Protein (Excitatory Amino Acid Transporter 4) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications. PMID: 17182680
Introduction
Eaat4 Protein (Excitatory Amino Acid Transporter 4) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@ref1992]
<div class="infobox infobox-protein"> [@ref1994a]
EAAT4 [@ref2001]
| | | |---|---| | Protein Name | EAAT4 | | Gene | [SLC1A6](/genes/slc1a6) | | UniProt ID | [P22732](https://www.uniprot.org/uniprot/P22732) | | Molecular Weight | ~65 kDa | | Subcellular Localization | Plasma membrane (neurons) | | Protein Family | SLC1 (EAAT) family | | Associated Diseases | [Epilepsy](/diseases/epilepsy), [Ataxia](/diseases/ataxia), [Neurodegeneration](/diseases/neurodegeneration) |
</div>
Structure
EAAT4 is a transmembrane protein with:
Eight transmembrane domains
A reentrant loop between transmembrane domains 7 and 8
Intracellular N- and C-termini
Glycosylation sites in extracellular loops
The transporter has a "transport gate" mechanism where the substrate binding site is alternately exposed to the extracellular and intracellular sides. EAAT4 contains ankyrin-binding motifs in its C-terminal domain, allowing association with the cytoskeleton. PMID: 20011524
Normal Function in the Nervous System
EAAT4 is a high-affinity glutamate transporter that:
Glutamate clearance: Removes glutamate from the extracellular space with high affinity (Km ~10 μM), preventing excitotoxic accumulation.
Sodium coupling: Cotransports 3 Na+ and 1 H+ with each glutamate, countertransporting 1 K+. This electrogenic process contributes to the resting membrane potential.
Eaat4 Protein (Excitatory Amino Acid Transporter 4) plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Eaat4 Protein (Excitatory Amino Acid Transporter 4) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Pathway & Interaction Diagram
Interactive diagram showing EAAT4's key relationships in the SciDEX knowledge graph (5 connections shown).