Eif2B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> |+ eIF2B Protein ! Protein Name | eIF2B Protein ! Gene | [EIF2B5](/genes/eif2b5) ! UniProt ID | [P49407](https://www.uniprot.org/uniprot/P49407) ! PDB IDs | 6O9Y, 6O9Z ! Molecular Weight | 33.9 kDa ! Subcellular Localization | Cytoplasm ! Protein Family | eIF2B family </div>
Overview
eIF2B Protein (EIF2B5) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
Structure
eIF2B forms a decameric complex of five subunits.
Normal Function
eIF2B is the guanine nucleotide exchange factor for eIF2. It is essential for initiating translation. eIF2B is a pentameric complex and is sensitive to eIF2-alpha phosphorylation.
Role in Disease
Mutations in eIF2B cause vanishing white matter disease, a progressive leukoencephalopathy. eIF2B dysfunction affects neuronal survival.
Therapeutic Targeting
ISRIB stabilizes eIF2B and reverses translational inhibition.
Background
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eIF2B Protein
Introduction
Eif2B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> |+ eIF2B Protein ! Protein Name | eIF2B Protein ! Gene | [EIF2B5](/genes/eif2b5) ! UniProt ID | [P49407](https://www.uniprot.org/uniprot/P49407) ! PDB IDs | 6O9Y, 6O9Z ! Molecular Weight | 33.9 kDa ! Subcellular Localization | Cytoplasm ! Protein Family | eIF2B family </div>
Overview
eIF2B Protein (EIF2B5) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
Structure
eIF2B forms a decameric complex of five subunits.
Normal Function
eIF2B is the guanine nucleotide exchange factor for eIF2. It is essential for initiating translation. eIF2B is a pentameric complex and is sensitive to eIF2-alpha phosphorylation.
Role in Disease
Mutations in eIF2B cause vanishing white matter disease, a progressive leukoencephalopathy. eIF2B dysfunction affects neuronal survival.
Therapeutic Targeting
ISRIB stabilizes eIF2B and reverses translational inhibition.
Background
The study of Eif2B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.