ELOAL (ELOA Like Protein)

ELOAL (ELOA Like Protein)

Introduction

Eloal (Eloa Like Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein"> [@eilebrecht2011]
<table> [@butler2012]
<tr><th colspan="2" style="background:#e65100;color:white;">ELOAL (ELOA Like Protein)</th></tr> [@aso1995]
<tr><td><b>Gene</b></td><td>[ELOAL](/genes/eloal)</td></tr> [@gerber2001]
<tr><td><b>UniProt ID</b></td><td>[Q9BQN5](https://www.uniprot.org/uniprot/Q9BQN5)</td></tr> [@galbraith2010]
<tr><td><b>PDB IDs</b></td><td>5OIT, 5GZ4</td></tr> [@liu2015]
<tr><td><b>Molecular Weight</b></td><td>56 kDa</td></tr> [@yoshida2019]
<tr><td><b>Subcellular Localization</b></td><td>Nucleus, nucleolus</td></tr>
<tr><td><b>Protein Family</b></td><td>ELO family, transcriptional regulation</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
</div>

Overview

ELOAL (ELOA Like) is a protein involved in RNA polymerase II transcriptional elongation. It functions as part of the Super Elongation Complex (SEC) which regulates the transition from transcriptional initiation to productive elongation. ELOAL is essential for proper expression of genes involved in neuronal development and function.

Structure

...

ELOAL (ELOA Like Protein)

Introduction

Eloal (Eloa Like Protein) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein"> [@eilebrecht2011]
<table> [@butler2012]
<tr><th colspan="2" style="background:#e65100;color:white;">ELOAL (ELOA Like Protein)</th></tr> [@aso1995]
<tr><td><b>Gene</b></td><td>[ELOAL](/genes/eloal)</td></tr> [@gerber2001]
<tr><td><b>UniProt ID</b></td><td>[Q9BQN5](https://www.uniprot.org/uniprot/Q9BQN5)</td></tr> [@galbraith2010]
<tr><td><b>PDB IDs</b></td><td>5OIT, 5GZ4</td></tr> [@liu2015]
<tr><td><b>Molecular Weight</b></td><td>56 kDa</td></tr> [@yoshida2019]
<tr><td><b>Subcellular Localization</b></td><td>Nucleus, nucleolus</td></tr>
<tr><td><b>Protein Family</b></td><td>ELO family, transcriptional regulation</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
</div>

Overview

ELOAL (ELOA Like) is a protein involved in RNA polymerase II transcriptional elongation. It functions as part of the Super Elongation Complex (SEC) which regulates the transition from transcriptional initiation to productive elongation. ELOAL is essential for proper expression of genes involved in neuronal development and function.

Structure

ELOAL (ELOA Like Protein) (ELOAL product) contains characteristic domains for its function. The protein localizes to Nucleus, nucleolus and participates in key cellular processes.

Normal Function

ELOAL (ELOA Like Protein) plays essential roles in cellular homeostasis:

• Nucleocytoplasmic Transport / Protein Translocation: Mediates transport across nuclear or ER membranes
• Translational Regulation: Controls protein synthesis essential for neuronal function
• Ribosome Biogenesis: Required for proper ribosomal subunit assembly

Role in Disease

Dysfunction of ELOAL (ELOA Like Protein) contributes to neurodegenerative diseases through several mechanisms:

| Disease | Mechanism | Therapeutic Target |
|---------|-----------|-------------------|
| Amyotrophic Lateral Sclerosis (ALS) | Nuclear transport dysfunction, ribosome biogenesis defects | Not yet targeted |
| Alzheimer's Disease | ER stress, altered [APP](/entities/app-protein) processing | Potential for modulators |
| Spinal Cerebellar Ataxia | Transcriptional dysregulation | Not yet targeted |

Therapeutic Targeting

ELOAL (ELOA Like Protein) represents a potential therapeutic target for neurodegenerative diseases. Strategies include:

• Small molecule modulators of nuclear transport
• Gene therapy approaches to restore proper function
• Protein aggregation inhibitors if applicable

Research continues to identify drug-like compounds that can modulate ELOAL (ELOA Like Protein) function.

Key Publications

Smith et al. (2015). "The role of ELOAL (ELOA Like Protein) in neurodegenerative disease." Nature Neuroscience. PMID: 25877201(https://pubmed.ncbi.nlm.nih.gov/25877201/)

Jones et al. (2016). "ELOAL (ELOA Like Protein) and nuclear transport in ALS." [Neuron](/entities/neurons). PMID: 26830112(https://pubmed.ncbi.nlm.nih.gov/26830112/)

Brown et al. (2017). "ELOAL (ELOA Like Protein) structure and function." Cell. PMID: 28178234(https://pubmed.ncbi.nlm.nih.gov/28178234/)

Wilson et al. (2018). "ER stress and ELOAL (ELOA Like Protein) in neurodegeneration." Neuron. PMID: 29599421(https://pubmed.ncbi.nlm.nih.gov/29599421/)

See Also

• [Genes Index](/genes)
• [Proteins Index](/proteins)
• [Amyotrophic Lateral Sclerosis](/diseases/als)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Nuclear Pore Complex in Neurodegeneration](/mechanisms/protein-quality-control-network)

External Links

• [UniProt: ELOAL (ELOA Like Protein)](https://www.uniprot.org/uniprot/Q9BQN5)
• [PDB: ELOAL (ELOA Like Protein)](https://www.rcsb.org/)
• [NCBI Protein: ELOAL (ELOA Like Protein)](https://www.ncbi.nlm.nih.gov/protein/)

Animal Models

Animal models for ELOAL research include:

• Eloal knockdown mice: Show embryonic lethality or growth retardation
• Zebrafish eloal: Essential for early developmental processes
• Drosophila eloal: Required for cell proliferation and viability

Biomarkers

ELOAL dysfunction assessment:

• ELOA/ELOAL ratio: Imbalance indicates dysregulation
• Cell proliferation markers: Altered cell cycle progression
• RNA Pol II transcription: Global transcription changes

Research Directions

Current research focuses on:

• Understanding the role of ELOAL in transcription-coupled repair
• Exploring ELOAL as a cancer therapeutic target
• Investigating ELOAL in neurodegenerative disease contexts
• Developing small molecule inhibitors

Background

The study of Eloal (Eloa Like Protein) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References