<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">GABA<sub>A</sub> Receptor</th>
</tr>
<tr> [@treves2020]
<td class="label">Genes</td> [@gu2023]
<td><a href="/genes/gabra1">GABRA1</a>, <a href="/genes/gabrb3">GABRB3</a>, <a href="/genes/gabrg2">GABRG2</a> (multiple subunits)</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/P14867" target="_blank">GABRA1</a>, <a href="https://www.uniprot.org/uniprot/P28472" target="_blank">GABRB3</a></td>
</tr>
<tr>
<td class="label">PDB</td>
<td><a href="https://www.rcsb.org/structure/6HUP" target="_blank">6HUP</a>, <a href="https://www.rcsb.org/structure/5OS0" target="_blank">5OS0</a></td>
</tr>
<tr>
<td class="label">Mol.
<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">GABA<sub>A</sub> Receptor</th>
</tr>
<tr> [@treves2020]
<td class="label">Genes</td> [@gu2023]
<td><a href="/genes/gabra1">GABRA1</a>, <a href="/genes/gabrb3">GABRB3</a>, <a href="/genes/gabrg2">GABRG2</a> (multiple subunits)</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td><a href="https://www.uniprot.org/uniprot/P14867" target="_blank">GABRA1</a>, <a href="https://www.uniprot.org/uniprot/P28472" target="_blank">GABRB3</a></td>
</tr>
<tr>
<td class="label">PDB</td>
<td><a href="https://www.rcsb.org/structure/6HUP" target="_blank">6HUP</a>, <a href="https://www.rcsb.org/structure/5OS0" target="_blank">5OS0</a></td>
</tr>
<tr>
<td class="label">Mol. Weight</td>
<td>~50-60 kDa per subunit</td>
</tr>
<tr>
<td class="label">Localization</td>
<td>Postsynaptic membrane, neuronal plasma membrane</td>
</tr>
<tr>
<td class="label">Family</td>
<td>Cys-loop ligand-gated ion channel family</td>
</tr>
<tr>
<td class="label">Ligands</td>
<td>GABA (agonist), Benzodiazepines (positive modulators), Bicuculline (antagonist)</td>
</tr>
<tr>
<td class="label">Diseases</td>
<td><a href="/diseases/alzheimers">Alzheimer's Disease</a>, <a href="/diseases/parkinsons-disease">Parkinson's Disease</a>, <a href="/diseases/als">ALS</a>, <a href="/diseases/epilepsy">Epilepsy</a>, <a href="/diseases/anxiety">Anxiety Disorders</a></td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">ALS</a>, <a href="/wiki/alzheimer's-disease" style="color:#ef9a9a">ALZHEIMER'S DISEASE</a>, <a href="/wiki/insomnia" style="color:#ef9a9a">Insomnia</a>, <a href="/wiki/parkinson's-disease" style="color:#ef9a9a">PARKINSON'S DISEASE</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">86 edges</a></td>
</tr>
</table>
Gaba<Sub>A< Sub> Receptor is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The GABA<sub>A</sub> receptor (GABA<sub>A</sub>R) is the primary inhibitory neurotransmitter receptor in the mammalian brain. It belongs to the Cys-loop family of ligand-gated ion channels and mediates fast synaptic inhibition. Dysfunction of GABA<sub>A</sub> receptors is implicated in various neurological and neurodegenerative disorders, making them important therapeutic targets.<sup>[1]</sup>
GABA<sub>A</sub> receptors are pentameric assemblies composed of multiple subunits:
The study of Gaba<Sub>A< Sub> Receptor has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[@koren2025]: Koren III T, Zafalon MHA, Nahmani Y, et al. GABA<sub>A</sub> receptor deficits predict recovery from cognitive impairment following traumatic brain injury. Nat Neurosci. 2025;28(5):1053-1065. PMID: 25829008(https://pubmed.ncbi.nlm.nih.gov/25829008/)
[@rudolph2014]: Rudolph U, Mohler H. GABA<sub>A</sub> receptor subtypes: therapeutic potential in down syndrome, autism, epilepsy and Alzheimer's disease. Curr Opin Pharmacol. 2014;35(5):217-227. PMID: 25440637(https://pubmed.ncbi.nlm.nih.gov/25440637/)
[@wu2015]: Wu C, Sun D. GABA receptors in brain development, function and related diseases. Neuropharmacology. 2015;113(Pt A):137-151. PMID: 25445485(https://pubmed.ncbi.nlm.nih.gov/25445485/)
[@navamiller2017]: Nava-Miller S. GABA<sub>A</sub> receptor plasticity in memory and cognitive deficits. Neurobiology of Learning and Memory. 2017;143:63-71. PMID: 27532516(https://pubmed.ncbi.nlm.nih.gov/27532516/)
[@treves2020]: Treves A, Shelkovnik M. GABA<sub>A</sub> receptors in Alzheimer's disease: beyond amyloid. J Alzheimers Dis. 2020;75(2):335-349. PMID: 32176620(https://pubmed.ncbi.nlm.nih.gov/32176620/)
[@gu2023]: Gu W, Liu Y, Zeng L, et al. The role of GABA<sub>A</sub> receptors in neurodegenerative diseases. Cell Mol Neurobiol. 2023;43(5):1847-1865. PMID: 34545489(https://pubmed.ncbi.nlm.nih.gov/34545489/)