IFRD1 Protein - Interferon-Related Developmental Regulator 1

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<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">IFRD1 Protein — Interferon-Related Developmental Regulator 1</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>Interferon-Related Developmental Regulator 1</td>
</tr>
<tr>
<td class="label">Gene</td>
<td><a href="/genes/ifrd1">IFRD1</a></td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td><a href="https://www.uniprot.org/uniprot/Q9UKV3" target="_blank">Q9UKV3</a></td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~46 kDa (415 aa)</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Nucleus, Cytoplasm</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>IFRD family</td>
</tr>
<tr>
<td class="label">Expression</td>
<td>Brain, Spinal cord, Muscle, Heart</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Introduction

Ifrd1 Protein Interferon Related Developmental Regulator 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

...

Introduction

Overview

IFRD1 Protein (Interferon-Related Developmental Regulator 1) is a 415-amino acid protein involved in transcriptional regulation, cellular differentiation, and neuroprotection [1]. The protein is expressed in various tissues, with highest levels in the brain and spinal cord, particularly in [neurons](/entities/neurons) and motor neurons [2].

Structure

Domain Organization

N-terminal Domain: Involved in protein-protein interactions
Central Region: Regulatory domain
C-terminal Domain: Transcriptional activation domain

Structural Features

Nuclear Localization Signal: Contains NLS for nuclear import
Transcription Activation Domain: Can activate transcription
Protein Interaction Motifs: Multiple interaction domains

Function

Transcriptional Regulation

IFRD1 functions as a transcriptional co-activator:

Chromatin Remodeling: Modifies histone acetylation
Transcriptional Activation: Activates target gene expression
Transcription Factor Recruitment: Recruits transcription factors to promoters

Cellular Functions

Neuronal Differentiation: Promotes neuronal differentiation and maturation

Stress Response: Modulates cellular stress responses

Neuroprotection: Provides neuroprotection against various insults

Muscle Development: Important for muscle fiber maturation

Role in Disease

Amyotrophic Lateral Sclerosis

IFRD1 is implicated in ALS [2]:

Motor Neuron Expression: Highly expressed in motor neurons
Disease Modifier: May influence ALS progression
Therapeutic Target: Potential target for neuroprotection

Cancer

Oncogenic Activity: Can promote tumor growth in some cancers
Cell Proliferation: Stimulates cell proliferation
Differentiation: Blocks cellular differentiation

Neurodegeneration

Neuroprotective Effects: Protects neurons from various insults
Stress Response: Enhances cellular stress tolerance
Aging: May play role in age-related changes

Therapeutic Potential

Drug Development

Gene Therapy: AAV-mediated IFRD1 delivery
Small Molecule Modulators: Compounds that enhance IFRD1 activity
Combination Therapy: With other neuroprotective agents

Biomarker Potential

Disease Biomarker: IFRD1 levels may serve as biomarker
Therapeutic Response: May predict treatment response

Interactions

Protein Interactions

p53: Tumor suppressor, cell cycle regulation
[NF-kB](/entities/nf-kb): Inflammation and stress response
MyoD: Muscle differentiation
[HDAC](/entities/hdac-enzymes) Complexes: Histone deacetylases

Background

The study of Ifrd1 Protein Interferon Related Developmental Regulator 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

[UniProt: Q9UKV3](https://www.uniprot.org/uniprot/Q9UKV3)
[NCBI Protein: IFRD1](https://www.ncbi.nlm.nih.gov/protein/NP_001538)
[Human Protein Atlas: IFRD1](https://www.proteinatlas.org/ENSG00000033178-IFRD1)

References

[Unknown, IFRD1 structure and function (2003)](https://pubmed.ncbi.nlm.nih.gov/12514192/)

[Unknown, IFRD1 in ALS and motor neuron disease (2007)](https://pubmed.ncbi.nlm.nih.gov/17656438/)

[Unknown, Neuroprotective functions of IFRD1 (2010)](https://pubmed.ncbi.nlm.nih.gov/20471812/)

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IFRD1 Protein - Interferon-Related Developmental Regulator 1