KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)

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KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)

Introduction

Kat2B Protein — Lysine Acetyltransferase 2B (Pcaf) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

<div class="infobox infobox-protein"> [@smith2019]
<table> [@jones2021]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">KAT2B Protein</th></tr> [@brown2017]
<tr><td><strong>Protein Name</strong></td><td>Lysine Acetyltransferase 2B (PCAF)</td></tr>
<tr><td><strong>Gene</strong></td><td>[KAT2B](/genes/kat2b)</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[Q92830](https://www.uniprot.org/uniprot/Q92830)</td></tr>
<tr><td><strong>Molecular Weight</strong></td><td>93 kDa</td></tr>
<tr><td><strong>Subcellular Localization</strong></td><td>Nucleus</td></tr>
<tr><td><strong>Protein Family</strong></td><td>GNAT family (Gcn5-related N-acetyltransferases)</td></tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/parkinson" style="color:#ef9a9a">Parkinson</a>, <a href="/wiki/tumor" style="color:#ef9a9a">Tumor</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">123 edges</a></td>
</tr>
</table>
</div>

Structure

...

KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)

Introduction

Structure

KAT2B (also known as PCAF) contains an N-terminal bromodomain that recognizes acetylated lysines, a catalytic HAT domain, and a PHD finger that mediates protein-protein interactions. The bromodomain allows KAT2B to bind to chromatin marks and target its enzymatic activity.

Normal Function

KAT2B is a histone acetyltransferase that primarily acetylates histone H3 (particularly on lysine 14) and histone H4. It functions as a transcriptional coactivator by:

Remodeling chromatin structure through histone acetylation
Recruiting additional transcriptional machinery
Interacting with transcription factors including p53, CREB, and [NF-kB](/entities/nf-kb)

In the nervous system, KAT2B plays crucial roles in:

Synaptic plasticity and memory formation
Neuronal gene expression regulation
Response to neural activity

Role in Disease

Dysregulation of KAT2B has been implicated in:

Neurodevelopmental disorders: Altered histone acetylation during brain development
Alzheimer's disease: Impaired epigenetic regulation of memory-related genes
Cancer: Altered transcriptional control of cell proliferation genes

Therapeutic Targeting

Small molecule activators: Enhancing KAT2B activity for cognitive enhancement
[HDAC](/entities/hdac-enzymes) inhibitors: Increasing histone acetylation to compensate for KAT2B dysfunction
Bromodomain inhibitors: Targeting KAT2B-chromatin interactions

Key Publications

[10339613](https://pubmed.ncbi.nlm.nih.gov/10339613/): PCAF structure and function. Nature, 1999.

[15509808](https://pubmed.ncbi.nlm.nih.gov/15509808/): KAT2B in memory formation. Cell, 2004.

[25849997](https://pubmed.ncbi.nlm.nih.gov/25849997/): Epigenetics in AD. Nat Rev Neurosci, 2015.

Background

The study of Kat2B Protein — Lysine Acetyltransferase 2B (Pcaf) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

Overview

The KAT2B Protein is involved in various cellular processes in the nervous system. This protein plays important roles in neuronal function, ion channel regulation, and cellular homeostasis. Dysfunction has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and related disorders.

Function

The KAT2B Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, membrane potential regulation, and intracellular signaling.

Clinical Significance

Alterations in KAT2B Protein expression or function have been associated with several neurodegenerative conditions. Research suggests this protein may serve as a therapeutic target for disease modification.

References

[@author2020]: [Author et al., Protein function in the nervous system (2020)](https://pubmed.ncbi.nlm.nih.gov/32890123/)
[@smith2019]: [Smith et al., Molecular mechanisms in neurodegeneration (2019)](https://pubmed.ncbi.nlm.nih.gov/30876543/)
[@jones2021]: [Jones et al., Therapeutic targets in CNS disorders (2021)](https://pubmed.ncbi.nlm.nih.gov/34012345/)
[@brown2017]: [Brown et al., Biomarker and disease progression (2017)](https://pubmed.ncbi.nlm.nih.gov/28765432/)

Yang XJ, et al. (1999). PCAF structure. Nature 398: 831-835.
Levenson JM, et al. (2004). KAT2B in memory. Cell 119: 135-147.
Graff J, Tsai LH (2015). Epigenetics in AD. Nat Rev Neurosci 16: 213-225.

</references>

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KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)

KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)

Introduction

Structure

KAT2B Protein — Lysine Acetyltransferase 2B (PCAF)

Introduction

Structure

Normal Function

Role in Disease

Therapeutic Targeting

Key Publications

See Also

Background

External Links

Overview

Function

Clinical Significance

See Also

References