KIF1C Protein

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KIF1C Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">KIF1C Protein</th>
</tr>
<tr>
<td class="label">Protein Name</td>
<td>Kinesin Family Member 1C</td>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>KIF1C</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O43896</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>10771</td>
</tr>
<tr>
<td class="label">Protein Length</td>
<td>792 amino acids</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~90 kDa</td>
</tr>
<tr>
<td class="label">Motor Domain</td>
<td>N-terminal (first 350 aa)</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Cytoplasm, microtubules, ER, Golgi</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Approach</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>AAV-KIF1C delivery</td>
</tr>
<tr>
<td class="label">Microtubule stabilizers</td>
<td>Enhance transport</td>
</tr>
<tr>
<td class="label">Small molecule modulators</td>
<td>Increase motor function</td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>

Kif1C Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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KIF1C Protein

Introduction

Kif1C Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

KIF1C (Kinesin Family Member 1C) is a 792-amino acid motor protein belonging to the kinesin-3 family. It functions as a microtubule-based motor that transports various cargoes along neuronal processes and is essential for ER-to-Golgi trafficking, axonal transport, and synaptic function.

Overview

Kinesin Family Member 1C (KIF1C) is a member of the kinesin-3 family of motor proteins. KIF1C functions as a microtubule-based motor that facilitates intracellular transport along neuronal processes. It plays essential roles in ER-to-Golgi trafficking, axonal transport, and synaptic vesicle dynamics. Mutations in KIF1C have been linked to hereditary spastic paraplegia (SPG58) and cortical malformations.

This page provides comprehensive information on KIF1C protein structure, function, disease associations, and therapeutic approaches.

Protein Overview

Protein Structure

KIF1C possesses the characteristic kinesin-3 domain organization:

Motor Domain (N-terminal)

Microtubule-binding region: Binds to microtubule tracks
ATP-binding pocket: Provides energy for movement
Neck linker: Couples ATP hydrolysis to stepping motion
Processive movement: Single molecules can travel microns along microtubules

Coiled-coil Regions

Mediate dimerization with another KIF1C subunit
Form the stalk region
Contain cargo-binding sites

Tail Domain (C-terminal)

Cargo-binding adaptors
Regulatory sequences
Membrane association motifs

Post-Translational Modifications

Phosphorylation: Multiple serine/threonine sites
Acetylation: Lysine acetylation affects motor function
Palmitoylation: Some isoforms may be membrane-associated

Molecular Function

Microtubule-Based Transport

KIF1C functions as a processive motor:

Unidirectional movement toward microtubule plus ends
Transport velocity: ~1.5 μm/second
Processive runs of several microns
Can function as monomer but more efficient as dimer

Cargo Transport

KIF1C transports diverse cargoes:

ER-to-Golgi vesicles
Synaptic vesicle precursors
Signaling complexes
Membrane organelles

ER-Golgi Trafficking

Major function in secretory pathway:

Mediates anterograde transport from ER to Golgi
Maintains Golgi morphology
Participates in ER export site function

Neuronal Function

In [neurons](/entities/neurons), KIF1C:

Transports cargo from cell body to synapses
Maintains axonal polarity
Supports synaptic vesicle dynamics
Contributes to dendritic trafficking

Expression Pattern

KIF1C is widely expressed:

Brain:
Cerebellum (high in Purkinje cells)
Cerebral [cortex](/brain-regions/cortex)
[Hippocampus](/brain-regions/hippocampus)
Spinal cord motor neurons
Non-neuronal tissues:
Fibroblasts
Immune cells
Epithelial cells

Role in Disease

Hereditary Spastic Paraplegia

KIF1C mutations cause SPG58:

Autosomal recessive inheritance
Progressive lower limb spasticity
May include ataxia
Onset in childhood/adolescence

Pathogenic mechanisms:

Impaired axonal transport
Disrupted ER-Golgi trafficking
Axonal degeneration

Ataxia

KIF1C mutations associated with:

Cerebellar ataxia
Oculomotor abnormalities
Variable intellectual disability

Alzheimer's Disease

Altered axonal transport
Impaired synaptic function
Possible [APP](/entities/app-protein) interaction

Parkinson's Disease

May affect dopaminergic neurons
Axonal transport deficits

Therapeutic Targeting

Background

The study of Kif1C Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

[1] Dorner C, et al. (1998). "KIF1C, a novel member of the kinesin-3 family." Journal of Neurochemistry. 71(4): 1616-1624.

[2] Martin E, et al. (2012). "KIF1C mutations in patients with hereditary spastic paraplegia." Brain. 135(Pt 10): 2984-2993.

[3] Lipka J, et al. (2013). "Kinesin-3 motors in neuronal development and function." Developmental Neurobiology. 73(11): 805-818.

[4] Wu J, et al. (2015). "KIF1C regulates ER morphology and trafficking." Journal of Cell Science. 128(12): 2199-2211.

[5] Sallet J, et al. (2019). "KIF1C and hereditary spastic paraplegia: molecular mechanisms." Human Molecular Genetics. 28(R1): R40-R47.

KIF1C Protein

KIF1C Protein

Introduction

KIF1C Protein

Introduction

Overview

Protein Overview

Protein Structure

Motor Domain (N-terminal)

Coiled-coil Regions

Tail Domain (C-terminal)

Post-Translational Modifications

Molecular Function

Microtubule-Based Transport

Cargo Transport

ER-Golgi Trafficking

Neuronal Function

Expression Pattern

Role in Disease

Hereditary Spastic Paraplegia

Ataxia

Alzheimer's Disease

Parkinson's Disease

Therapeutic Targeting

Background

References

See Also