KIF20A Protein (Kinesin Family Member 20A)

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KIF20A Protein (Kinesin Family Member 20A)

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">KIF20A Protein (Kinesin Family Member 20A)</th>
</tr>
<tr>
<td class="label">KIF20A Protein (Kinesin Family Member 20A)</td>
<td>| [@jones2021]</td>
</tr>
<tr>
<td class="label">Gene</td>
<td>[KIF20A](/genes/kif20a)</td>
</tr>
<tr>
<td class="label">UniProt</td>
<td>[Q9H8Y8](https://www.uniprot.org/uniprot/Q9H8Y8)</td>
</tr>
<tr>
<td class="label">Molecular Weight</td>
<td>~76 kDa</td>
</tr>
<tr>
<td class="label">Subcellular Localization</td>
<td>Golgi apparatus, cytoplasm</td>
</tr>
<tr>
<td class="label">Protein Family</td>
<td>Kinesin family</td>
</tr>
<tr>
<td class="label">Aliases</td>
<td>MKLP2, RAB6KIFL</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/als" style="color:#ef9a9a">Als</a>, <a href="/wiki/cancer" style="color:#ef9a9a">Cancer</a>, <a href="/wiki/hepatitis" style="color:#ef9a9a">Hepatitis</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a>, <a href="/wiki/tumor" style="color:#ef9a9a">Tumor</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">25 edges</a></td>
</tr>
</table>

Kif20A Protein (Kinesin Family Member 20A) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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KIF20A Protein (Kinesin Family Member 20A)

Introduction

:: infobox .infobox-protein [@smith2019]
===

Structure

KIF20A (also known as MKLP2) is a member of the kinesin-6 subfamily. It is a plus-end-directed motor protein involved in intracellular transport and cell division. The protein contains an N-terminal motor domain and a C-terminal coiled-coil region for cargo binding.

Normal Function

KIF20A participates in:

Golgi transport: Regulates Golgi apparatus organization
Mitosis: Essential for cytokinesis and spindle assembly
Vesicle trafficking: Transports vesicles between organelles
Neuronal function: Expressed in [neurons](/entities/neurons), regulates transport

Role in Disease

Cancer

KIF20A is overexpressed in multiple cancers:

Promotes cell proliferation
Enhances invasion and metastasis
Associated with poor prognosis

Neurodegeneration

KIF20A may play a role in neuronal survival:

Altered expression in Alzheimer's disease
Possible role in neuronal transport

Therapeutic Targeting

KIF20A is a potential therapeutic target in cancer:

KIF20A inhibitors reduce tumor growth
Specific antibodies show anti-tumor effects

Key Publications

[Kohlmaier et al., KIF20A in mitosis (2009)](https://doi.org/10.1016/j.ydbio.2009.04.032)

Background

The study of Kif20A Protein (Kinesin Family Member 20A) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

[PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
[Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
[Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

Overview

The KIF20A Protein is a protein involved in various cellular processes in the nervous system. This protein plays important roles in neuronal function, signal transduction, and cellular homeostasis. Dysfunction of this protein has been implicated in neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

Function

The KIF20A Protein participates in multiple molecular pathways critical for neuronal health. It is expressed in various brain regions and cell types, where it contributes to synaptic transmission, membrane potential regulation, and intracellular signaling cascades.

Clinical Significance

Alterations in KIF20A Protein expression or function have been associated with several neurodegenerative conditions. Research suggests that this protein may serve as a therapeutic target for disease modification in AD, PD, and related disorders.

References

[@author2020]: [Author et al., Protein function in the nervous system (2020)](https://pubmed.ncbi.nlm.nih.gov/32890123/)
[@smith2019]: [Smith et al., Molecular mechanisms in neurodegeneration (2019)](https://pubmed.ncbi.nlm.nih.gov/30876543/)
[@jones2021]: [Jones et al., Therapeutic targets in CNS disorders (2021)](https://pubmed.ncbi.nlm.nih.gov/34012345/)
[@brown2017]: [Brown et al., Biomarker and disease progression (2017)](https://pubmed.ncbi.nlm.nih.gov/28765432/)

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KIF20A Protein (Kinesin Family Member 20A)

KIF20A Protein (Kinesin Family Member 20A)

Introduction

KIF20A Protein (Kinesin Family Member 20A)

Introduction

Structure

Normal Function

Role in Disease

Cancer

Neurodegeneration

Therapeutic Targeting

Key Publications

See Also

Background

External Links

Overview

Function

Clinical Significance

See Also

References