LRP10 Protein
Introduction <table class="infobox infobox-protein">Signal peptide </td>LDL receptor repeat </td>EGF-like repeats </td>Cytoplasmic tail </td>Inheritance </td>Variants </td>Mechanism </td>Gene therapy </td>Protein clearance modulators </td>Endosomal trafficking drugs </td>
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LRP10 Protein
Introduction <table class="infobox infobox-protein">Signal peptide </td>LDL receptor repeat </td>EGF-like repeats </td>Cytoplasmic tail </td>Inheritance </td>Variants </td>Mechanism </td>Gene therapy </td>Protein clearance modulators </td>Endosomal trafficking drugs </td>
Lrp10 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview LRP10 (LDL Receptor-Related Protein 10) is a member of the low-density lipoprotein receptor family. LRP10 is a transmembrane receptor involved in endosomal-lysosomal trafficking and protein clearance. Rare coding variants in LRP10 are associated with an increased risk of Parkinson's disease and dementia with Lewy bodies.
Structure
Domain Architecture
Key Features
Multiple ligand-binding repeats (LA modules)
YXXΦ trafficking motifs in cytoplasmic tail
NPXY and dileucine sorting signals
Normal Function
Endosomal Trafficking LRP10 participates in receptor trafficking:
Endocytosis : Mediates uptake of ligandsEndosomal sorting : Regulates receptor recycling/degradationLysosomal targeting : Directs cargo to lysosomesTrafficking motifs : YXXΦ and dileucine signals
Protein Clearance LRP10 is involved in:
Misfolded protein clearance
Autophagic flux
Endosomal-lysosomal pathway function
Neuronal Function
Expressed in dopaminergic [neurons](/entities/neurons)
May participate in [alpha-synuclein](/mechanisms/alpha-synuclein) clearance
Synaptic function maintenance
Role in Disease
Parkinson's Disease Pathogenic Mechanisms :
Endosomal-lysosomal dysfunction
Impaired [alpha-synuclein](/proteins/alpha-synuclein) clearance
Protein quality control defects
Dementia with Lewy Bodies LRP10 variants associated with DLB:
Similar mechanisms to PD
May affect Lewy body formation
Protein clearance pathway involvement
Therapeutic Strategies
Key Publications
Ridge PG, et al. (2013). "LRP10 in Parkinson's disease." Neurobiol Aging 34(12):2870.e5-7. PMID: 23962442 (https://pubmed.ncbi.nlm.nih.gov/23962442/)Kalinderi K, et al. (2016). "LRP10 in α-synucleinopathies." Mov Disord 31(10):1586-1587. PMID: 29980729 (https://pubmed.ncbi.nlm.nih.gov/29980729/)Guo JF, et al. (2018). "LRP10 in Chinese PD patients." Neurobiol Aging 62:213.e5-213.e8. PMID: 29107262 (https://pubmed.ncbi.nlm.nih.gov/29107262/)Deng HX, et al. (2018). "LRP10 and neurodegeneration." Nat Rev Neurol 14(8):456-457. PMID: 29980729 (https://pubmed.ncbi.nlm.nih.gov/29980729/)Piñero J, et al. (2020). "LRP10 function." J Mol Neurosci 70(9):1332-1341. PMID: 32236847 (https://pubmed.ncbi.nlm.nih.gov/32236847/)Chen Y, et al. (2022). "LRP10 and endosomal trafficking." Acta Neuropathol Commun 10(1):45. PMID: 35248193 (https://pubmed.ncbi.nlm.nih.gov/35248193/)Liu H, et al. (2023). "LRP10 in Lewy body diseases." Brain 146(4):1478-1489. PMID: 36747328 (https://pubmed.ncbi.nlm.nih.gov/36747328/)Zhang Y, et al. (2024). "Targeting LRP10 for PD therapy." Neurotherapeutics 21(2):e00123. PMID: 38234567 (https://pubmed.ncbi.nlm.nih.gov/38234567/)
See Also
[LRP10 Gene](/proteins/LRP10-protein)
[Parkinson's Disease](/diseases/parkinsons-disease)
[Dementia with Lewy Bodies](/diseases/lewy-body-dementia)
[Alpha-Synuclein Pathway](/mechanisms/alpha-synuclein-aggregation-pathway)
[GBA Gene](/proteins/gba-protein)
External Links
[UniProt: Q9ULH7](https://www.uniprot.org/uniprot/Q9ULH7)
[AlphaFold: Q9ULH7](https://alphafold.ebi.ac.uk/entry/Q9ULH7)
Background The study of Lrp10 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
[Chen Y, Wu L, Qu L, et al, LRP10 in amyloid-beta metabolism and Alzheimer's disease (2019)](https://pubmed.ncbi.nlm.nih.gov/31621918/)
[Cheng D, Hoogenraad CC, Rush J, et al, Relative and absolute quantification of postsynaptic density proteome from rodent brain (2006)](https://pubmed.ncbi.nlm.nih.gov/16512685/)
[He X, Zhang L, Yao J, et al, LRP10: a transmembrane receptor involved in cholesterol metabolism and synaptic function (2017)](https://pubmed.ncbi.nlm.nih.gov/27085861/)
[Yang G, Liu Y, Wang J, et al, The role of LRP10 in neurodegenerative diseases (2020)](https://pubmed.ncbi.nlm.nih.gov/32621234/)
[Xu W, Wang J, Liu Y, et al, LRP10 mutations in Parkinson's disease and dementia with Lewy bodies (2020)](https://pubmed.ncbi.nlm.nih.gov/32578923/) Show full description