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MELK Protein

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protein541 wordssynced 2026-04-02

MELK Protein

Introduction

Melk Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ MELK Protein
! Protein Name
| MELK Protein
! Gene
| [MELK](/genes/melk)
! UniProt ID
| [Q9Y588](https://www.uniprot.org/uniprot/Q9Y588)
! PDB IDs
| 5K4U, 5K52
! Molecular Weight
| 38.4 kDa
! Subcellular Localization
| Nucleus, Cytoplasm
! Protein Family
| SNRK1 family
</div>

Overview

MELK Protein (MELK) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

MELK has a kinase domain and a regulatory region.

Normal Function

MELK (Maternal Embryonic Leucine Zipper Kinase) is a serine/threonine kinase involved in cell proliferation, stem cell maintenance, and stress responses. It is highly expressed in neural progenitors.

Role in Disease

MELK is overexpressed in cancer. Its role in neurodegeneration is being investigated.

Background


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