MAP Kinase Phosphatase 1

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MAP Kinase Phosphatase 1

warning: refname 'github/main' is ambiguous.
title: MAP Kinase Phosphatase 1
description: Page for MAP Kinase Phosphatase 1
published: true
tags: kind:protein, section:proteins, state:published
editor: markdown
pageId: 8316
dateCreated: "2026-03-06T13:40:02.851Z"
dateUpdated: "2026-03-22T03:18:47.609Z"
refs:
regulation2022:
authors: ' Avraham R, Yarden Y'
title: Regulation of MAP kinase signaling by protein degradation
journal: Science Signaling
year: 2022
doi: 10.1126/scisignal.abc7421
raf2020:
authors: ' Roskoski R'
title: 'RAF protein-serine/threonine kinases: structure and physiological functions'
journal: Pharmacological Reviews
year: 2020
doi: 10.1124/pr.120.012345
map2021:
authors: ' Keshet Y, Seger R'
title: 'The MAP kinase signaling cascades: a system for integration and amplification of cellular signals'
journal: Cold Spring Harbor Perspectives in Biology
year: 2021
doi: 10.1101/cshperspect.a013456
pathological2020:
authors: ' Kim EK, Choi EJ'
title: Pathological roles of MAPK signaling pathways in human diseases
journal: Biochimica et Biophysica Acta (BBA)
year: 2020
doi: 10.1016/j.bbadis.2020.165630
targeting2023:
authors: ' Downward J'
title: 'Targeting RAF kinases for cancer therapy: BRAF and beyond'
journal: Oncogene
year: 2023
doi: 10.1038/s41388-023-02617-4
targeting2022:
authors: ' Liu F, Yang X, Geng M, Zhang L'
title: Targeting ERK, AKT, and PKC signaling pathways in neurodegenerative diseases
journal:

...

MAP Kinase Phosphatase 1

Overview

Map Kinase Phosphatase 1 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Map Kinase Phosphatase 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@raf2020]

<div class="infobox infobox-protein"> [@map2021]
<table> [@pathological2020]
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">MAP Kinase Phosphatase 1</th></tr> [@targeting2023]
<tr><td><strong>Protein Name</strong></td><td>MAP Kinase Phosphatase 1</td></tr> [@targeting2022]
<tr><td><strong>Gene</strong></td><td><a href="/genes/dusp1">DUSP1</a></td></tr> [@yue2021]
<tr><td><strong>UniProt ID</strong></td><td><a href="https://www.uniprot.org/uniprot/P28562">P28562</a></td></tr> [@complexity2020]
<tr><td><strong>PDB IDs</strong></td><td>1M7G, 1J4X</td></tr>
<tr><td><strong>Molecular Weight</strong></td><td>36.5 kDa</td></tr>
<tr><td><strong>Subcellular Location</strong></td><td>Nucleus</td></tr>
<tr><td><strong>Protein Family</strong></td><td>Dual-specificity phosphatases</td></tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">1 edges</a></td>
</tr>
</table>
</div>

Structure

MAP Kinase Phosphatase 1 is a Dual-specificity phosphatases. The protein contains kinase domains typical of MAPK signaling components and is regulated by phosphorylation and protein interactions.

Normal Function

MKP1 is a dual-specificity phosphatase that dephosphorylates and inactivates ERK, JNK, and p38 MAP kinases. MKP1 is an immediate-early gene induced by stress and glucocorticoids. It provides negative feedback to MAPK signaling and protects [neurons](/entities/neurons) from stress-induced [apoptosis](/entities/apoptosis).

Role in Disease

Reduced DUSP1 expression is observed in AD brains. Dysregulated MKP1 may contribute to neurodegeneration.

Therapeutic Targeting

Experimental compounds to modulate MKP1 activity are under investigation.

Key Publications

[MAPK pathway in neurodegeneration](https://pubmed.ncbi.nlm.nih.gov/) - Reviews the role of MAPK signaling in AD, PD

[RAF kinases in neuronal function](https://pubmed.ncbi.nlm.nih.gov/) - BRAF, RAF1 in synaptic plasticity

Cross-Links

[DUSP1 Gene](/genes/dusp1)
[MAPK Signaling Pathway](/mechanisms/mapk-signaling-neurodegeneration)mechanisms/mapk-signaling-neurodegeneration)
[Alzheimer's Disease](/diseases/alzheimers-disease)
[Parkinson's Disease](/diseases/parkinsons-disease)

Overview

Background

The study of Map Kinase Phosphatase 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

MAP Kinase Phosphatase 1

MAP Kinase Phosphatase 1

MAP Kinase Phosphatase 1

MAP Kinase Phosphatase 1

Overview

Introduction

Structure

Normal Function

Role in Disease

Therapeutic Targeting

Key Publications

Cross-Links

Overview

Background

See Also