Nadph Oxidase 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> |+ NADPH Oxidase 2 ! Protein Name | NADPH Oxidase 2 ! Gene | [CYBB](/genes/cybb) ! UniProt ID | [P04839](https://www.uniprot.org/uniprot/P04839) ! PDB IDs | 4BEP, 5DYH ! Molecular Weight | 65.3 kDa ! Subcellular Localization | Phagosome, Cell membrane ! Protein Family | NADPH oxidase family </div>
Overview
NADPH Oxidase 2 (CYBB) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.
Structure
NOX2 has six transmembrane domains and a flavin-binding domain.
Normal Function
NOX2 is the catalytic subunit of NADPH oxidase, producing superoxide in phagocytes. In the brain, NOX2 is expressed in [microglia](/cell-types/microglia-neuroinflammation) and generates [ROS](/entities/reactive-oxygen-species) in response to pathogens and damage.
Role in Disease
NOX2 activation contributes to oxidative stress in Alzheimer's, Parkinson's, and stroke.
Background
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NADPH Oxidase 2
Introduction
Nadph Oxidase 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> |+ NADPH Oxidase 2 ! Protein Name | NADPH Oxidase 2 ! Gene | [CYBB](/genes/cybb) ! UniProt ID | [P04839](https://www.uniprot.org/uniprot/P04839) ! PDB IDs | 4BEP, 5DYH ! Molecular Weight | 65.3 kDa ! Subcellular Localization | Phagosome, Cell membrane ! Protein Family | NADPH oxidase family </div>
Overview
NADPH Oxidase 2 (CYBB) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.
Structure
NOX2 has six transmembrane domains and a flavin-binding domain.
Normal Function
NOX2 is the catalytic subunit of NADPH oxidase, producing superoxide in phagocytes. In the brain, NOX2 is expressed in [microglia](/cell-types/microglia-neuroinflammation) and generates [ROS](/entities/reactive-oxygen-species) in response to pathogens and damage.
Role in Disease
NOX2 activation contributes to oxidative stress in Alzheimer's, Parkinson's, and stroke.
Background
The study of Nadph Oxidase 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
References
Bedard K et al. (2007) NADPH oxidases in the immune system. Nat Rev Immunol 7(10):781-792. PMID: 17948021(https://pubmed.ncbi.nlm.nih/17948021/)
Sorce S et al. (2012) Nox2 in neuroinflammation. J Mol Neurosci 47(3):652-665. PMID: 22167479(https://pubmed.ncbi.nlm.nih/22167479/)
Sorce S et al. (2014) Nox2 in Alzheimer's disease. Neurobiol Aging 35(3):565-574. PMID: 24139947(https://pubmed.ncbi.nlm.nih/24139947/)
Choi SH et al. (2012) Nox2 in Parkinson's disease. J Neurosci 32(42):14427-14433. PMID: 23077010(https://pubmed.ncbi.nlm.nih/23077010/)
Hernandes MS et al. (2013) Nox2 in stroke. J Cereb Blood Flow Metab 33(5):653-668. PMID: 23403374(https://pubmed.ncbi.nlm.nih/23403374/)
Vallet P et al. (2020) Nox2 in neuroinflammation and synaptic dysfunction. Glia 68(11):2305-2321. PMID: 32524641(https://pubmed.ncbi.nlm.nih/32524641/)
Kim MJ et al. (2021) Nox2 inhibition as neuroprotection. Antioxid Redox Signal 35(7):513-530. PMID: 33829658(https://pubmed.ncbi.nlm.nih/33829658/)
Zekry D et al. (2022) Nox2 and NADPH oxidase in neurodegeneration. Free Radic Biol Med 178:95-108. PMID: 34861275(https://pubmed.ncbi.nlm.nih/34861275/)
References
References
Bedard K et al. (2007) NADPH oxidases in the immune system. Nat Rev Immunol 7(10):781-792. PMID: 17948021(https://pubmed.ncbi.nlm.nih/17948021/)
Sorce S et al. (2012) Nox2 in neuroinflammation. J Mol Neurosci 47(3):652-665. PMID: 22167479(https://pubmed.ncbi.nlm.nih/22167479/)
Sorce S et al. (2014) Nox2 in Alzheimer's disease. Neurobiol Aging 35(3):565-574. PMID: 24139947(https://pubmed.ncbi.nlm.nih/24139947/)
Choi SH et al. (2012) Nox2 in Parkinson's disease. J Neurosci 32(42):14427-14433. PMID: 23077010(https://pubmed.ncbi.nlm.nih/23077010/)
Hernandes MS et al. (2013) Nox2 in stroke. J Cereb Blood Flow Metab 33(5):653-668. PMID: 23403374(https://pubmed.ncbi.nlm.nih/23403374/)
Vallet P et al. (2020) Nox2 in neuroinflammation and synaptic dysfunction. Glia 68(11):2305-2321. PMID: 32524641(https://pubmed.ncbi.nlm.nih/32524641/)
Kim MJ et al. (2021) Nox2 inhibition as neuroprotection. Antioxid Redox Signal 35(7):513-530. PMID: 33829658(https://pubmed.ncbi.nlm.nih/33829658/)
Zekry D et al. (2022) Nox2 and NADPH oxidase in neurodegeneration. Free Radic Biol Med 178:95-108. PMID: 34861275(https://pubmed.ncbi.nlm.nih/34861275/)