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VPS34 Protein

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protein528 wordssynced 2026-04-02

VPS34 Protein

Introduction

Vps34 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ VPS34 Protein
! Protein Name
| VPS34 Protein
! Gene
| [PIK3C3](/genes/pik3c3)
! UniProt ID
| [Q8NEB9](https://www.uniprot.org/uniprot/Q8NEB9)
! PDB IDs
| 4OYS, 5DF6
! Molecular Weight
| 100.7 kDa
! Subcellular Localization
| Endosome, Autophagosome
! Protein Family
| PI3K class III
</div>

Overview

VPS34 Protein (PIK3C3) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

VPS34 has a C-terminal kinase domain.

Normal Function

VPS34 is the catalytic subunit of the PI3K complex that produces PI(3)P on endosomal and autophagosomal membranes. It is essential for [autophagy](/entities/autophagy) initiation and endosomal trafficking.

Role in Disease

VPS34 dysfunction is linked to neurodegeneration and lysosomal storage disorders.

Therapeutic Targeting

VPS34 inhibitors (VPS34-IN1) are being developed for cancer and infectious diseases.

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Related Entities
PIK3C3PROTEIN
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