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RhoA Protein

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protein675 wordssynced 2026-04-02

RhoA Protein

Introduction

Rhoa Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ RhoA Protein
! Protein Name
| RhoA Protein
! Gene
| [RHOA](/genes/rhoa)
! UniProt ID
| [P61586](https://www.uniprot.org/uniprot/P61586)
! PDB IDs
| 1TX4, 1CEK
! Molecular Weight
| 19.7 kDa
! Subcellular Localization
| Cell membrane, Cytoplasm
! Protein Family
| Rho GTPase family
</div>

Overview

RhoA Protein (RHOA) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

RhoA has a classic GTPase fold with switch I and II regions. It cycles between active GTP-bound and inactive GDP-bound states.

Normal Function

RhoA is a small GTPase that regulates actin cytoskeleton dynamics, cell adhesion, and migration. It controls stress fiber formation and contractility through its downstream effectors ROCK1 and ROCK2. In [neurons](/entities/neurons), RhoA regulates dendritic spine morphology and synaptic plasticity.

Role in Disease


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