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ROCK2 Protein

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protein655 wordssynced 2026-04-02

ROCK2 Protein

Introduction

Rock2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ ROCK2 Protein
! Protein Name
| ROCK2 Protein
! Gene
| [ROCK2](/genes/rock2)
! UniProt ID
| [O75116](https://www.uniprot.org/uniprot/O75116)
! PDB IDs
| 2F2U, 2H9D
! Molecular Weight
| 160.8 kDa
! Subcellular Localization
| Cell membrane, Cytoplasm
! Protein Family
| ROCK family
</div>

Overview

ROCK2 Protein (ROCK2) is a protein involved in cellular signaling and molecular processes. It is expressed in various tissues including the brain and plays roles in neuronal function and disease mechanisms.

Structure

ROCK2 has a kinase domain, coiled-coil region, and Rho-binding domain.

Normal Function

ROCK2 is a Rho-associated kinase with similar functions to ROCK1. It has distinct tissue expression patterns, with high expression in brain. ROCK2 regulates synaptic plasticity and is involved in neuropsychiatric disorders.

Role in Disease

ROCK2 is implicated in Alzheimer's disease and depression. ROCK2 inhibitors have anxiolytic and cognitive-enhancing effects.

Therapeutic Targeting


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