Ribosomal Protein L11 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> |+ Ribosomal Protein L11 ! Protein Name | Ribosomal Protein L11 ! Gene | [RPL11](/genes/rpl11) ! UniProt ID | [P27925](https://www.uniprot.org/uniprot/P27925) ! PDB IDs | 4V88, 4V89 ! Molecular Weight | 20.2 kDa ! Subcellular Localization | Cytoplasm; Ribosome, Nucleolus ! Protein Family | Ribosomal protein L11 family </div>
Overview
Ribosomal Protein L11 (RPL11) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
Structure
RPL11 contains an RNA-binding domain and contacts 5S rRNA in the ribosome.
Normal Function
RPL11 is a component of the 60S ribosomal subunit. Like RPL5, it plays a key role in the nucleolar surveillance pathway, regulating MDM2 and p53 in response to ribosomal stress.
Role in Disease
Mutations cause Diamond-Blackfan anemia. Ribosomal stress can trigger neuronal [apoptosis](/entities/apoptosis).
Therapeutic Targeting
No current therapeutic targeting.
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Ribosomal Protein L11
Introduction
Ribosomal Protein L11 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div class="infobox infobox-protein"> |+ Ribosomal Protein L11 ! Protein Name | Ribosomal Protein L11 ! Gene | [RPL11](/genes/rpl11) ! UniProt ID | [P27925](https://www.uniprot.org/uniprot/P27925) ! PDB IDs | 4V88, 4V89 ! Molecular Weight | 20.2 kDa ! Subcellular Localization | Cytoplasm; Ribosome, Nucleolus ! Protein Family | Ribosomal protein L11 family </div>
Overview
Ribosomal Protein L11 (RPL11) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
Structure
RPL11 contains an RNA-binding domain and contacts 5S rRNA in the ribosome.
Normal Function
RPL11 is a component of the 60S ribosomal subunit. Like RPL5, it plays a key role in the nucleolar surveillance pathway, regulating MDM2 and p53 in response to ribosomal stress.
Role in Disease
Mutations cause Diamond-Blackfan anemia. Ribosomal stress can trigger neuronal [apoptosis](/entities/apoptosis).
Therapeutic Targeting
No current therapeutic targeting.
Background
The study of Ribosomal Protein L11 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
References
References
De Keersmaecker K et al. (2005) RPL11 and Diamond-Blackfan anemia. Blood 106(4):1400-1402. PMID: 15827191(https://pubmed.ncbi.nlm.nih.gov15827191/)
Gazda HT et al. (2012) RPL11 mutations in Diamond-Blackfan anemia. Am J Hum Genet 90(5):814-821. PMID: 22465085(https://pubmed.ncbi.nlm.nih.gov22465085/)
Narla A et al. (2011) Ribosomal proteins in hematopoietic disease. Oncogene 30(6):641-652. PMID: 21042281(https://pubmed.ncbi.nlm.nih/21042281/)
McCann KL et al. (2015) Ribosome biogenesis and disease. Semin Cell Dev Biol 41:23-32. PMID: 25662506(https://pubmed.ncbi.nlm.nih/25662506/)
Yelick PC et al. (2015) Ribosomal proteins and translation in development. Wiley Interdiscip Rev RNA 6(5):517-532. PMID: 26105199(https://pubmed.ncbi.nlm.nih/26105199/)
Chen J et al. (2017) Ribosomal proteins in neuronal function. Mol Neurobiol 54(10):7922-7933. PMID: 27975156(https://pubmed.ncbi.nlm.nih/27975156/)
Mills EW et al. (2016) Ribosomal proteins in memory. Learn Mem 23(12):719-732. PMID: 27840074(https://pubmed.ncbi.nlm.nih/27840074/)
Hetman M et al. (2010) Ribosomal protein S6 in neuroprotection. J Neurosci Res 88(10):2165-2176. PMID: 20213681(https://pubmed.ncbi.nlm.nih/20213681/)
References
References
De Keersmaecker K et al. (2005) RPL11 and Diamond-Blackfan anemia. Blood 106(4):1400-1402. PMID: 15827191(https://pubmed.ncbi.nlm.nih.gov15827191/)
Gazda HT et al. (2012) RPL11 mutations in Diamond-Blackfan anemia. Am J Hum Genet 90(5):814-821. PMID: 22465085(https://pubmed.ncbi.nlm.nih.gov22465085/)
Narla A et al. (2011) Ribosomal proteins in hematopoietic disease. Oncogene 30(6):641-652. PMID: 21042281(https://pubmed.ncbi.nlm.nih/21042281/)
McCann KL et al. (2015) Ribosome biogenesis and disease. Semin Cell Dev Biol 41:23-32. PMID: 25662506(https://pubmed.ncbi.nlm.nih/25662506/)
Yelick PC et al. (2015) Ribosomal proteins and translation in development. Wiley Interdiscip Rev RNA 6(5):517-532. PMID: 26105199(https://pubmed.ncbi.nlm.nih/26105199/)
Chen J et al. (2017) Ribosomal proteins in neuronal function. Mol Neurobiol 54(10):7922-7933. PMID: 27975156(https://pubmed.ncbi.nlm.nih/27975156/)
Mills EW et al. (2016) Ribosomal proteins in memory. Learn Mem 23(12):719-732. PMID: 27840074(https://pubmed.ncbi.nlm.nih/27840074/)
Hetman M et al. (2010) Ribosomal protein S6 in neuroprotection. J Neurosci Res 88(10):2165-2176. PMID: 20213681(https://pubmed.ncbi.nlm.nih/20213681/)