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Ribosomal Protein S6

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protein552 wordssynced 2026-04-02

Ribosomal Protein S6

Introduction

Ribosomal Protein S6 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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<div class="infobox infobox-protein">
|+ Ribosomal Protein S6
! Protein Name
| Ribosomal Protein S6
! Gene
| [RPS6](/genes/rps6)
! UniProt ID
| [P62753](https://www.uniprot.org/uniprot/P62753)
! PDB IDs
| 4V88, 4V89
! Molecular Weight
| 28.7 kDa
! Subcellular Localization
| Cytoplasm; Ribosome
! Protein Family
| Ribosomal protein S6 family
</div>

Overview

Ribosomal Protein S6 (RPS6) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.

Structure

RPS6 contains multiple phosphorylation sites in its C-terminal tail.

Normal Function

RPS6 is a component of the 40S ribosomal subunit and is a major substrate for several kinases including S6K1. It is involved in translational control and cell proliferation. Phosphorylation of RPS6 is associated with synaptic plasticity.

Role in Disease

Dysregulated RPS6 phosphorylation has been linked to Alzheimer's disease and autism spectrum disorders.

Therapeutic Targeting


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RPS6PROTEIN
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