<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">S100A9 Protein - Calgranulin B</th>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Anti-S100A9 antibodies</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">TLR4 inhibitors</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">[RAGE](/entities/rage-receptor) antagonists</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">S100A9 knockout</td>
<td>Research</td>
</tr>
</table>
S100A9 Protein Calgranulin B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">S100A9 Protein - Calgranulin B</th>
</tr>
<tr>
<td class="label">Approach</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Anti-S100A9 antibodies</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">TLR4 inhibitors</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">[RAGE](/entities/rage-receptor) antagonists</td>
<td>Preclinical</td>
</tr>
<tr>
<td class="label">S100A9 knockout</td>
<td>Research</td>
</tr>
</table>
S100A9 Protein Calgranulin B is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
<div style="background:#f8f9fa;border:1px solid #ddd;padding:15px;border-radius:5px;margin:10px 0;"> [@calgranulin]
<h3 style="margin-top:0;">S100A9 Protein - Calgranulin B</h3> [@therapeutic]
<table style="width:100%;font-size:14px;"> [@biomarker]
<tr><td style="padding:5px;font-weight:bold;">Symbol</td><td style="padding:5px;">S100A9</td></tr> [@microglial]
<tr><td style="padding:5px;font-weight:bold;">Full Name</td><td style="padding:5px;">S100 Calcium Binding Protein A9</td></tr> [@parkinsons]
<tr><td style="padding:5px;font-weight:bold;">Aliases</td><td style="padding:5px;">Calgranulin B, MRP14, Myeloid-related protein 14</td></tr> [@calprotectin]
<tr><td style="padding:5px;font-weight:bold;">Molecular Weight</td><td>13.2 kDa</td></tr> [@neurofibrillary]
<tr><td style="padding:5px;font-weight:bold;">Protein Family</td><td>S100 EF-hand calcium-binding proteins</td></tr>
<tr><td style="padding:5px;font-weight:bold;">Associated Diseases</td><td>AD, PD, ALS, MS, Rheumatoid Arthritis, Inflammatory Bowel Disease</td></tr>
</table>
</div>
S100A9 (S100 Calcium Binding Protein A9), also known as Calgranulin B or Myeloid-Related Protein 14 (MRP14), is a member of the S100 family of EF-hand calcium-binding proteins. Like its partner S100A8, S100A9 forms a heterodimer (calprotectin) that functions as a Damage-Associated Molecular Pattern (DAMP) molecule. This complex is a major player in neuroinflammation and is implicated in the pathogenesis of Alzheimer's disease, Parkinson's disease, ALS, and multiple sclerosis.
S100A9 is a 13.2 kDa protein containing two EF-hand calcium-binding motifs. The C-terminal EF-hand is the high-affinity calcium-binding site. S100A9 can form both homodimers and heterodimers with S100A8. The S100A8/A9 heterodimer (calprotectin) is the biologically active form involved in immune signaling.
The study of S100A9 Protein Calgranulin B has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.