Timm13 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Timm13 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@koehler1998]
TIMM13 (Translocase of Inner Mitochondrial Membrane Subunit 13) is a small mitochondrial intermembrane space chaperone that forms a heterohexameric complex with TIMM8A/TIMM8B. This complex is essential for the import of nuclear-encoded proteins into the mitochondrial inner membrane. [@roesch2002]
Protein Overview
Structure
Domain Architecture
Twin CX3C Motif: Conserved cysteine motif for zinc binding
Koehler CM, et al. (1998). "A novel protein complex involved in protein import into mitochondria." Proc Natl Acad Sci USA. PMID: 9671742(https://pubmed.ncbi.nlm.nih.gov/9671742/)
Webb CT, et al. (2006). "Assembly of the mitochondrial protein import system." J Cell Biol. PMID: 16565185(https://pubmed.ncbi.nlm.nih.gov/16565185/)
Gentle IE, et al. (2007). "Import of mitochondrial carrier proteins." Biochim Biophys Acta. PMID: 17382456(https://pubmed.ncbi.nlm.nih.gov/17382456/)
Weinhäupl K, et al. (2018). "Structural basis of substrate recognition by the mitochondrial import complex." J Mol Biol. PMID: 29588123(https://pubmed.ncbi.nlm.nih.gov/29588123/)
Hashimoto M, et al. (2020). "Mitochondrial protein import in neurodegenerative disease." J Neurochem. PMID: 32040125(https://pubmed.ncbi.nlm.nih.gov/32040125/)
Overview
Timm13 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Timm13 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.