TNFR2 (TNF Receptor 2, p75, CD120b; encoded by the [TNFRSF1B gene](/genes/tnfrsf1b)) is a 75 kDa transmembrane receptor for tumor necrosis factor that primarily mediates neuroprotective and cell survival signaling, in contrast to the death-promoting TNFR1.
Overview
TNFR2 is a type I transmembrane glycoprotein of 461 amino acids that belongs to the TNF receptor superfamily<sup>[1]</sup>. Unlike [TNFR1](/genes/tnfrsf1a), TNFR2 lacks an intracellular death domain and instead signals through TRAF (TNF receptor-associated factor) proteins to promote cell survival, tissue repair, and immunomodulation<sup>[2]</sup>. In the CNS, TNFR2 is the primary mediator of TNF's neuroprotective effects, including neuronal survival, [oligodendrocyte](/cell-types/oligodendrocytes) protection, and anti-inflammatory microglial polarization<sup>[3]</sup>. [@faustman2010]
TNFR2 has a modular extracellular-transmembrane-intracellular architecture<sup>[1]</sup>:
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TNFR2 (TNFRSF1B Protein)
Introduction
TNFR2 (TNF Receptor 2, p75, CD120b; encoded by the [TNFRSF1B gene](/genes/tnfrsf1b)) is a 75 kDa transmembrane receptor for tumor necrosis factor that primarily mediates neuroprotective and cell survival signaling, in contrast to the death-promoting TNFR1.
Overview
TNFR2 is a type I transmembrane glycoprotein of 461 amino acids that belongs to the TNF receptor superfamily<sup>[1]</sup>. Unlike [TNFR1](/genes/tnfrsf1a), TNFR2 lacks an intracellular death domain and instead signals through TRAF (TNF receptor-associated factor) proteins to promote cell survival, tissue repair, and immunomodulation<sup>[2]</sup>. In the CNS, TNFR2 is the primary mediator of TNF's neuroprotective effects, including neuronal survival, [oligodendrocyte](/cell-types/oligodendrocytes) protection, and anti-inflammatory microglial polarization<sup>[3]</sup>. [@faustman2010]
[Wajant H et al., Tumor necrosis factor signaling (2003) (2003)](https://doi.org/10.1038/sj.cdd.4401189)
[Unknown, Faustman D & Davis M, TNF receptor 2 pathway: drug target for autoimmune diseases (2010) (2010)](https://doi.org/10.1038/nrd3030)
[Unknown, Probert L, TNF and its receptors in the CNS: the essential, the desirable and the deleterious effects (2015) (2015)](https://doi.org/10.1016/j.neuroscience.2015.06.038)
[Unknown, McCoy MK & Bhatt DG, TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease (2018) (2018)](https://doi.org/10.1186/s12974-018-1075-3)
[Fischer R et al., Selective activation of tumor necrosis factor receptor II induces anti-inflammatory responses and reduces experimental arthritis (2018) (2018)](https://doi.org/10.1002/art.40413)