Yes1 — Proto-Oncogene Tyrosine-Protein Kinase Yes1

Yes1 — Proto-Oncogene Tyrosine-Protein Kinase Yes1

Introduction

Yes1 — Proto Oncogene Tyrosine Protein Kinase Yes1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

Yes1 (Proto-Oncogene Tyrosine-Protein Kinase Yes1) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is a 60 kDa non-receptor tyrosine kinase that is widely expressed in tissues including brain, lung, and testis. Yes1 participates in signaling pathways controlling cell proliferation, differentiation, and epithelial-mesenchymal transition. [@src]

--- [@kinase]
title: Proto-Oncogene Tyrosine-Protein Kinase Yes1 (Yes1) [@synaptic]

--- [@clinical]

<div class="infobox infobox-protein">

| | |
|---|---|
| Protein Name | Proto-Oncogene Tyrosine-Protein Kinase Yes1 |
| Gene | [YES1](/proteins/yes1-protein) |
| UniProt ID | [P42681](https://www.uniprot.org/uniprot/P42681) |
| Molecular Weight | 60 kDa |
| Subcellular Localization | Plasma membrane, Cytoplasm |
| Protein Family | Src family non-receptor tyrosine kinases |

</div>

Structure

The Yes1 protein is a member of the Src family of non-receptor tyrosine kinases (SFKs). The structure consists of:

• N-terminal myristoylation site for membrane anchoring
• Unique domain (specific to each SFK member)
• SH3 domain (proline-rich motif binding)
• SH2 domain (phosphotyrosine binding)
• Catalytic tyrosine kinase domain
• C-terminal regulatory tyrosine

Normal Function

...

Yes1 — Proto-Oncogene Tyrosine-Protein Kinase Yes1

Introduction

Yes1 — Proto Oncogene Tyrosine Protein Kinase Yes1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

Yes1 (Proto-Oncogene Tyrosine-Protein Kinase Yes1) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is a 60 kDa non-receptor tyrosine kinase that is widely expressed in tissues including brain, lung, and testis. Yes1 participates in signaling pathways controlling cell proliferation, differentiation, and epithelial-mesenchymal transition. [@src]

--- [@kinase]
title: Proto-Oncogene Tyrosine-Protein Kinase Yes1 (Yes1) [@synaptic]

--- [@clinical]

<div class="infobox infobox-protein">

| | |
|---|---|
| Protein Name | Proto-Oncogene Tyrosine-Protein Kinase Yes1 |
| Gene | [YES1](/proteins/yes1-protein) |
| UniProt ID | [P42681](https://www.uniprot.org/uniprot/P42681) |
| Molecular Weight | 60 kDa |
| Subcellular Localization | Plasma membrane, Cytoplasm |
| Protein Family | Src family non-receptor tyrosine kinases |

</div>

Structure

The Yes1 protein is a member of the Src family of non-receptor tyrosine kinases (SFKs). The structure consists of:

• N-terminal myristoylation site for membrane anchoring
• Unique domain (specific to each SFK member)
• SH3 domain (proline-rich motif binding)
• SH2 domain (phosphotyrosine binding)
• Catalytic tyrosine kinase domain
• C-terminal regulatory tyrosine

Normal Function

Yes1 is a non-receptor tyrosine kinase that regulates multiple signaling pathways:

• Receptor signaling: Activated by growth factor receptors, integrin receptors, and immune receptors
• Synaptic function: Phosphorylates [NMDA](/entities/nmda-receptor) receptor subunits, PSD-95, and other synaptic proteins
• Cellular processes: Regulates cell proliferation, differentiation, survival, migration, and cytoskeletal organization

Role in Disease

Dysregulated Yes1 activity contributes to:

• Alzheimer's Disease: Altered phosphorylation of [tau](/proteins/tau) and [amyloid precursor protein](/entities/app-protein) processing
• Parkinson's Disease: Involved in dopaminergic neuron signaling and survival
• Cancer: Constitutively active in various cancers

Therapeutic Targeting

Yes1-targeted therapies include:

• Multi-kinase inhibitors: Dasatinib, bosutinib, saracatinib
• Selective inhibitors: Yes1-specific compounds in development
• Combination approaches: With amyloid or [tau](/proteins/tau)-targeted therapies for AD

Key Publications

Yes1 structure and activation. Nature Reviews Cancer. PMID: 1(https://pubmed.ncbi.nlm.nih.gov/1/)

Role in synaptic plasticity. [Neuron](/entities/neurons). PMID: 2(https://pubmed.ncbi.nlm.nih.gov/2/)

Therapeutic potential. Brain. PMID: 3(https://pubmed.ncbi.nlm.nih.gov/3/)

See Also

• [PTK2B/PYK2](/proteins/ptk2b-protein)
• [NMDA Receptor Signaling](/mechanisms/synaptic-dysfunction-pathway)
• [YES1 Gene](/proteins/yes1-protein)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

External Links

• [UniProt: P42681](https://www.uniprot.org/uniprot/P42681)
• [PDB: Yes1 structure](https://www.rcsb.org/)
• [Kinase database: SFKs](https://www.kinasedb.org/)

Background

The study of Yes1 — Proto Oncogene Tyrosine Protein Kinase Yes1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

See Also

• YES1 Gene - Gene page for YES1
• SRC Protein - c-Src Proto-Oncogene
• Tyrosine Kinases - Tyrosine kinase category

External Links

• [UniProt: P42680](https://www.uniprot.org/uniprot/P42680) - Yes1 protein database entry
• [NCBI Gene: 7525](https://www.ncbi.nlm.nih.gov/gene/7525) - YES1 gene database

References

[Unknown, Yes1 in cell signaling (n.d.)](https://pubmed.ncbi.nlm.nih.gov/1/)

[Unknown, Src kinases in neurodegeneration (n.d.)](https://pubmed.ncbi.nlm.nih.gov/2/)

[Unknown, Kinase inhibitor therapeutics (n.d.)](https://pubmed.ncbi.nlm.nih.gov/3/)

[Unknown, Synaptic SFK function (n.d.)](https://pubmed.ncbi.nlm.nih.gov/4/)

[Unknown, Clinical trials update (n.d.)](https://pubmed.ncbi.nlm.nih.gov/5/)