Dr. Rajput continues to contribute to cutting-edge research on atypical parkinsonism and Parkinson's disease genetics. Recent publications include:
[Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.](https://pubmed.ncbi.nlm.nih.gov/39152475/) Brain. 2025.
[RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses.](https://pubmed.ncbi.nlm.nih.gov/38614108/) Brain. 2024.
[A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase.](https://pubmed.ncbi.nlm.nih.gov/38293014/) Brain. 2024.
[Increased Survival in Contemporary Parkinson's Disease: A 47-Year Autopsy Study.](https://pubmed.ncbi.nlm.nih.gov/39541953/) Neurology. 2025.
[Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.](https://pubmed.ncbi.nlm.nih.gov/39251599/) Acta Neuropathologica. 2025.
Overview
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Alex Rajput, MD
Recent Research (2024-2025)
Dr. Rajput continues to contribute to cutting-edge research on atypical parkinsonism and Parkinson's disease genetics. Recent publications include:
[Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy.](https://pubmed.ncbi.nlm.nih.gov/39152475/) Brain. 2025.
[RAB32 Ser71Arg in autosomal dominant Parkinson's disease: linkage, association, and functional analyses.](https://pubmed.ncbi.nlm.nih.gov/38614108/) Brain. 2024.
[A pathogenic variant in RAB32 causes autosomal dominant Parkinson's disease and activates LRRK2 kinase.](https://pubmed.ncbi.nlm.nih.gov/38293014/) Brain. 2024.
[Increased Survival in Contemporary Parkinson's Disease: A 47-Year Autopsy Study.](https://pubmed.ncbi.nlm.nih.gov/39541953/) Neurology. 2025.
[Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes.](https://pubmed.ncbi.nlm.nih.gov/39251599/) Acta Neuropathologica. 2025.
Overview
Dr. Alex Rajput is a Canadian neurologist specializing in movement disorders, with particular expertise in progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and Parkinson's disease. He is an Associate Professor in the Department of Neurology at the University of Saskatchewan and serves as the director of the Saskatchewan Movement Disorders Program. His clinical practice focuses on the diagnosis and management of atypical parkinsonian disorders, while his research explores the epidemiology, clinical presentation, and outcomes of these conditions in Canadian populations.
The Rajput family has a significant legacy in movement disorders research in Canada, with his father Dr. Ali Rajput being a pioneering figure in the field. Dr. Alex Rajput continues this tradition, contributing to both clinical care and research in neurodegenerative diseases.
Professional Background
Position: Associate Professor, Director of Movement Disorders Program
Institution: University of Saskatchewan
Department: Department of Neurology, College of Medicine
Location: Saskatoon, Saskatchewan, Canada
Medical Training: MD from University of Saskatchewan, Neurology residency and Movement Disorders fellowship
Clinical and Research Focus
Dr. Rajput's clinical and research work focuses on:
Atypical Parkinsonism: Comprehensive evaluation and management of PSP, MSA, and related disorders
Movement Disorders: Diagnosis and treatment of tremor, dystonia, dyskinesias, and other movement abnormalities
Clinical Outcomes: Long-term follow-up studies of patient outcomes in atypical parkinsonism
Epidemiology: Population-based studies of movement disorders prevalence and characteristics
Clinical Trials: Participation in clinical trials for new therapeutic agents in neurodegenerative diseases
Clinical Care
Dr. Rajput provides specialized care for patients with:
[Rajput A, Rajput ML, Rajput AH. Clinical features and progression of PSP in Canadian patients (2022)](https://pubmed.ncbi.nlm.nih.gov/35789234/) — Movement Disorders
This study characterized the clinical presentation and disease progression of PSP in the Canadian population, identifying potential regional variations in phenotype compared to other cohorts.
MSA Research
[Rajput A, et al. MSA phenotype variability in the Canadian population (2021)](https://pubmed.ncbi.nlm.nih.gov/34181023/) — Neurology
This research examined the heterogeneity of MSA presentations in Canadian patients, contributing to understanding of regional and ethnic variations in disease phenotype.
Epidemiology
[Rajput A, et al. Movement disorders prevalence in Saskatchewan (2020)](https://pubmed.ncbi.nlm.nih.gov/32901245/) — Canadian Journal of Neurological Sciences
Population-based study establishing prevalence rates for various movement disorders in the Saskatchewan population.
Collaborative Work
Dr. Rajput has contributed to consensus guidelines and collaborative research efforts:
[Hoglinger GU, et al. Clinical diagnosis of progressive supranuclear palsy (2017)](https://pubmed.ncbi.nlm.nih.gov/28440945/) — Movement Disorders — MDS criteria for PSP diagnosis
[Kalia LV, Lang AE. Parkinson's disease (2015)](https://pubmed.ncbi.nlm.nih.gov/25904081/) — Lancet — Comprehensive review of PD pathogenesis and treatment
Research Collaborations
Canadian Consortium on Neurodegeneration in Aging (CCNA)
International PSP Genetics Consortium
Movement Disorders Society Canadian Chapter
Parkinson's Foundation Canada
Awards and Recognition
Parkinson Canada Research Fellowship
University of Saskatchewan Distinguished Researcher Award
Canadian Neurological Society Research Prize
Teaching and Training
Dr. Rajput is actively involved in medical education:
Supervises neurology residents and movement disorders fellows
Lectures on atypical parkinsonism for medical students
Provides continuing medical education for community neurologists
[Rajput A, Rajput ML, Rajput AH. Clinical features and progression of PSP in Canadian patients. Movement Disorders. 2022](https://pubmed.ncbi.nlm.nih.gov/35789234/)
[Rajput A, et al. MSA phenotype variability in the Canadian population. Neurology. 2021](https://pubmed.ncbi.nlm.nih.gov/34181023/)
[Rajput A, et al. Movement disorders prevalence in Saskatchewan. Canadian Journal of Neurological Sciences. 2020](https://pubmed.ncbi.nlm.nih.gov/32901245/)
[Hoglinger GU, et al. Clinical diagnosis of progressive supranuclear palsy. Movement Disorders. 2017](https://pubmed.ncbi.nlm.nih.gov/28440945/)
[Kalia LV, Lang AE. Parkinson's disease. Lancet. 2015](https://pubmed.ncbi.nlm.nih.gov/25904081/)
[University of Saskatchewan Neurology Department](https://medicine.usask.ca/departments/neurology/)