<table class="infobox infobox-therapeutic">
<tr>
<th class="infobox-header" colspan="2">Treatment Rankings</th>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>[Lecanemab](/entities/lecanemab)</td>
</tr>
<tr>
<td class="label">2</td>
<td>[Donanemab](/entities/donanemab)</td>
</tr>
<tr>
<td class="label">3</td>
<td>Aducanumab</td>
</tr>
<tr>
<td class="label">4</td>
<td>Semorinemab</td>
</tr>
<tr>
<td class="label">5</td>
<td>Gosuranemab</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>[Donepezil](/entities/donepezil)</td>
</tr>
<tr>
<td class="label">2</td>
<td>Memantine</td>
</tr>
<tr>
<td class="label">3</td>
<td>[Rivastigmine](/entities/rivastigmine)</td>
</tr>
<tr>
<td class="label">4</td>
<td>Galantamine</td>
</tr>
<tr>
<td class="label">5</td>
<td>Namzaric</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Levodopa/Carbidopa</td>
</tr>
<tr>
<td class="label">2</td>
<td>Pramipexole</td>
</tr>
<tr>
<td class="label">3</td>
<td>Rotigotine</td>
</tr>
<tr>
<td class="label">4</td>
<td>Rasagiline</td>
</tr>
<tr>
<td class="label">5</td>
<td>Entacapone</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Deep Brain Stimulation</td>
</tr>
<tr>
<td class="label">2</td>
<td>Levodopa-carbidopa intestinal gel</td>
</tr>
<tr>
<td class="label">3</td>
<td>Apomorphine infusion</td>
</tr>
<tr>
<td class="label">4</td>
<td>Duodopa</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>[Relyvrio](/therapeutics/relyvrio-neurodegeneration) (Sodium Phenylbutyrate/Taurursodiol)</td>
</tr>
<tr>
<td class="label">2</td>
<td>[Edaravone](/therapeutics/amyotrophic-lateral-sclerosis-treatment)</td>
</tr>
<tr>
<td class="label">3</td>
<td>Riluzole</td>
</tr>
<tr>
<td class="label">4</td>
<td>Tofersen</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Tofersen</td>
</tr>
<tr>
<td class="label">2</td>
<td>BIIB078</td>
</tr>
<tr>
<td class="label">3</td>
<td>ASO targeting [FUS](/genes/fus)</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Non-invasive ventilation (NIV)</td>
</tr>
<tr>
<td class="label">2</td>
<td>Percutaneous endoscopic gastrostomy (PEG) tube</td>
</tr>
<tr>
<td class="label">3</td>
<td>Speech therapy</td>
</tr>
<tr>
<td class="label">4</td>
<td>Physical therapy</td>
</tr>
<tr>
<td class="label">5</td>
<td>Occupational therapy</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Baclofen or Tizanidine</td>
</tr>
<tr>
<td class="label">2</td>
<td>Amitriptyline or Glycopyrrolate</td>
</tr>
<tr>
<td class="label">3</td>
<td>Quinine or Mexiletine</td>
</tr>
<tr>
<td class="label">4</td>
<td>SSRIs or SNRIs</td>
</tr>
<tr>
<td class="label">5</td>
<td>Lorazepam</td>
</tr>
<tr>
<td class="label">Trial</td>
<td>Intervention</td>
</tr>
<tr>
<td class="label">HEALEY ALS Platform</td>
<td>Multiple arms</td>
</tr>
<tr>
<td class="label">CNTN4</td>
<td>CNversyt</td>
</tr>
<tr>
<td class="label">Masitinib</td>
<td>Masitinib</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>SSRIs</td>
</tr>
<tr>
<td class="label">2</td>
<td>Trazodone</td>
</tr>
<tr>
<td class="label">3</td>
<td>Valproate</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Levodopa/Carbidopa</td>
</tr>
<tr>
<td class="label">2</td>
<td>Amantadine</td>
</tr>
<tr>
<td class="label">3</td>
<td>Pramipexole</td>
</tr>
<tr>
<td class="label">4</td>
<td>Benztropine</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Prizm lenses</td>
</tr>
<tr>
<td class="label">2</td>
<td>Vision therapy</td>
</tr>
<tr>
<td class="label">3</td>
<td>Artificial tears</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>SSRIs (Sertraline, Escitalopram)</td>
</tr>
<tr>
<td class="label">2</td>
<td>Methylphenidate</td>
</tr>
<tr>
<td class="label">3</td>
<td>Dextromethorphan/Quinidine</td>
</tr>
<tr>
<td class="label">4</td>
<td>Modafinil</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>[Donepezil](/entities/donepezil)</td>
</tr>
<tr>
<td class="label">2</td>
<td>[Rivastigmine](/entities/rivastigmine)</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Semorinemab</td>
</tr>
<tr>
<td class="label">2</td>
<td>Gantenerumab</td>
</tr>
<tr>
<td class="label">3</td>
<td>Tilavonemab</td>
</tr>
<tr>
<td class="label">4</td>
<td>AADvac1</td>
</tr>
<tr>
<td class="label">5</td>
<td>LTMX (Leurometaximel)</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Physical therapy</td>
</tr>
<tr>
<td class="label">2</td>
<td>Occupational therapy</td>
</tr>
<tr>
<td class="label">3</td>
<td>Speech therapy (LSVT LOUD)</td>
</tr>
<tr>
<td class="label">4</td>
<td>Swallowing therapy</td>
</tr>
<tr>
<td class="label">Agent</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Bepranemab</td>
<td>Anti-tau antibody</td>
</tr>
<tr>
<td class="label">Eisoselenomethyl</td>
<td>Selenoprotein</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Multidisciplinary team</td>
</tr>
<tr>
<td class="label">2</td>
<td>Caregiver support</td>
</tr>
<tr>
<td class="label">3</td>
<td>Environmental modifications</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Levodopa/Carbidopa</td>
</tr>
<tr>
<td class="label">2</td>
<td>Pramipexole</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Botulinum toxin</td>
</tr>
<tr>
<td class="label">2</td>
<td>Benzodiazepines (Clonazepam)</td>
</tr>
<tr>
<td class="label">3</td>
<td>Baclofen</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Levetiracetam</td>
</tr>
<tr>
<td class="label">2</td>
<td>Clonazepam</td>
</tr>
<tr>
<td class="label">3</td>
<td>Valproic acid</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>[Donepezil](/entities/donepezil)</td>
</tr>
<tr>
<td class="label">2</td>
<td>[Rivastigmine](/entities/rivastigmine)</td>
</tr>
<tr>
<td class="label">3</td>
<td>Memantine</td>
</tr>
<tr>
<td class="label">4</td>
<td>SSRIs</td>
</tr>
<tr>
<td class="label">5</td>
<td>Methylphenidate</td>
</tr>
<tr>
<td class="label">6</td>
<td>Quetiapine</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Bepranemab</td>
</tr>
<tr>
<td class="label">2</td>
<td>Tilavonemab</td>
</tr>
<tr>
<td class="label">3</td>
<td>Gantenerumab</td>
</tr>
<tr>
<td class="label">Rank</td>
<td>Treatment</td>
</tr>
<tr>
<td class="label">1</td>
<td>Physical therapy</td>
</tr>
<tr>
<td class="label">2</td>
<td>Occupational therapy</td>
</tr>
<tr>
<td class="label">3</td>
<td>Speech therapy</td>
</tr>
<tr>
<td class="label">4</td>
<td>Botulinum toxin</td>
</tr>
<tr>
<td class="label">Agent</td>
<td>Mechanism</td>
</tr>
<tr>
<td class="label">Antisense oligonucleotides</td>
<td>Tau reduction</td>
</tr>
<tr>
<td class="label">AAV gene therapy</td>
<td>Tau reduction</td>
</tr>
</table>
This page ranks therapeutic approaches and drugs for neurodegenerative diseases based on clinical evidence, FDA approval status, and therapeutic potential. [@cummings2024]
When selecting treatments, consider: