{"artifact":{"id":"SDA-2026-04-15-gap-debate-20260410-112545-377c1d9e","artifact_type":"analysis","entity_ids":null,"title":"How do synthetic EVs achieve brain-specific targeting while avoiding reticuloendothelial clearance?","quality_score":0.5,"created_by":"autonomous","provenance_chain":null,"content_hash":"357878915d332db27786d66a9ba1db0fd2845d5fc9663c8c3bdd02fb44c76c2e","metadata":{"origin_type":"v1_polymorphic_backfill","source_table":"analyses","_schema_version":1},"created_at":"2026-04-15T18:49:05.098197-07:00","updated_at":"2026-04-15T18:49:05.098197-07:00","version_number":3,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"a88e195e-3aa8-4b7b-9d20-dc68b06ae4f2","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"autonomous"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wp-168d5d038251","link_type":"related","strength":0.6,"evidence":"Analysis discusses topic related to wiki page 'Blood-Brain Barrier Biology and Crossing Strategies'"},{"target_artifact_id":"wp-ea1f316b1a52","link_type":"related","strength":0.6,"evidence":"Analysis discusses topic related to wiki page 'Blood-Brain Barrier Dysfunction in Neurodegeneration'"},{"target_artifact_id":"wp-966340bfc022","link_type":"related","strength":0.6,"evidence":"Analysis discusses topic related to wiki page 'ABCB1 — ATP-Binding Cassette Subfamily B Member 1'"},{"target_artifact_id":"h-959a4677","link_type":"related","strength":0.5,"evidence":"Analysis related to hypothesis about Transferrin receptor / BBB transcytosis target gene=TFRC"},{"target_artifact_id":"h-62e56eb9","link_type":"related","strength":0.5,"evidence":"Analysis related to hypothesis about Aquaporin-4 water transport / glymphatic clearance target gene=AQP4"},{"target_artifact_id":"h-cb833ed8","link_type":"related","strength":0.5,"evidence":"Analysis related to hypothesis about Cellular senescence / SASP signaling target gene=CD38/NAMPT"}],"incoming_links":[],"current_artifact_id":"SDA-2026-04-15-gap-debate-20260410-112545-377c1d9e","is_canonical":true,"supersede_chain":["SDA-2026-04-15-gap-debate-20260410-112545-377c1d9e"]}