{"artifact":{"id":"analysis-SDA-2026-04-03-gap-aging-mouse-brain-20260402","artifact_type":"analysis","entity_ids":"[]","title":"Gene expression changes in aging mouse brain predicting neurodegenerative vulnerability — Analysis","quality_score":0.4,"created_by":"orchestra-ci","provenance_chain":"[{\"step\": \"ci_notebook_stub_link_repair\", \"analysis_id\": \"SDA-2026-04-03-gap-aging-mouse-brain-20260402\", \"timestamp\": \"2026-04-04T23:29:50.541509+00:00\"}]","content_hash":null,"metadata":{"stub":true,"source":"ci_notebook_coverage","analysis_id":"SDA-2026-04-03-gap-aging-mouse-brain-20260402","file_sha256":"40f29db944714c3b51635f83060bf1311d027ce651922b20aca407799193c30b","_schema_version":1},"created_at":"2026-04-04T16:29:50.541509-07:00","updated_at":"2026-04-04T16:29:50.541509-07:00","version_number":6,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"ci_stub","origin_url":null,"lifecycle_changed_at":"2026-04-04T16:29:50.541509-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"e8d2eb9b-7e38-45c1-8601-4082723f647a","artifact_dir":"data/scidex-artifacts/e8/e8d2eb9b-7e38-45c1-8601-4082723f647a","primary_filename":"sda-2026-04-03-gap-aging-mouse-brain-20260402.html","accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":"2026-04-28T20:23:43.549586-07:00","hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"orchestra-ci"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-datasets","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Datasets"},{"target_artifact_id":"wiki-mechanisms-aging-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: aging-neurodegeneration"},{"target_artifact_id":"wiki-hypotheses","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Hypotheses"},{"target_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Neurodegeneration"},{"target_artifact_id":"wiki-mechanisms","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Mechanisms"},{"target_artifact_id":"wiki-cell-types-aging-associated-astrocytes","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"target_artifact_id":"wiki-cell-types-aging-oligodendrocytes","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"target_artifact_id":"wiki-cell-types-aging-microglia","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"target_artifact_id":"wiki-mechanisms-aging-to-ad-switch-trigger","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"target_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"related","strength":0.63,"evidence":"Reverse: KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"target_artifact_id":"notebook-SDA-2026-04-03-gap-aging-mouse-brain-20260402","link_type":"produces","strength":1.0,"evidence":"CI notebook coverage stub registration"}],"incoming_links":[{"source_artifact_id":"notebook-SDA-2026-04-03-gap-aging-mouse-brain-20260402","link_type":"derives_from","strength":1.0,"evidence":"CI notebook coverage stub registration"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-datasets","link_type":"mentions","strength":0.6,"evidence":"Title match: Datasets"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-aging-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Title match: aging-neurodegeneration"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-hypotheses","link_type":"mentions","strength":0.6,"evidence":"Title match: Hypotheses"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"mentions","strength":0.6,"evidence":"Title match: Neurodegeneration"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Title match: Mechanisms"},{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-genes-ace","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> APP"},{"source_artifact_id":"wiki-proteins-app","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> APP"},{"source_artifact_id":"wiki-genes-app","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> APP"},{"source_artifact_id":"wiki-ideas-payload-app-dosage-reduction-ds-therapy","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> APP"},{"source_artifact_id":"wiki-genes-cxcl10","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> CXCL10"},{"source_artifact_id":"wiki-proteins-gpx4","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> GPX4"},{"source_artifact_id":"wiki-genes-gpx4","link_type":"related","strength":0.4,"evidence":"KG edge: ACE --[co_associated_with]--> GPX4"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.5,"evidence":"KG edge: ACE --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-genes-cxcr3","link_type":"related","strength":0.5,"evidence":"KG edge: CXCL10 --[codes_for_ligand]--> CXCR3"},{"source_artifact_id":"wiki-cell-types-aging-associated-astrocytes","link_type":"related","strength":0.7,"evidence":"KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"source_artifact_id":"wiki-cell-types-aging-oligodendrocytes","link_type":"related","strength":0.7,"evidence":"KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"source_artifact_id":"wiki-cell-types-aging-microglia","link_type":"related","strength":0.7,"evidence":"KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"source_artifact_id":"wiki-mechanisms-aging-neurodegeneration","link_type":"related","strength":0.7,"evidence":"KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"source_artifact_id":"wiki-mechanisms-aging-to-ad-switch-trigger","link_type":"related","strength":0.7,"evidence":"KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"source_artifact_id":"wiki-mechanisms-aging-vs-neurodegeneration-comparison","link_type":"related","strength":0.7,"evidence":"KG edge: aging --[causes (aging causes early transcriptomic changes in oligo)]--> oligodendrocyte dysfunction"},{"source_artifact_id":"wiki-therapeutics-ferroptosis-therapy-parkinsons-disease","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-therapeutics-ferroptosis-modulation-therapy","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-therapeutics-ferroptosis-inhibitors","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-hypotheses-ferroptosis-parkinsons","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-ideas-payload-ferroptosis-inhibitor","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-investment-ferroptosis-neurodegeneration","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-cell-types-ferroptosis-sensitive-neurons","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-lipid-peroxidation-4r-tauopathies","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-neurodegeneration","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-4r-tauopathies","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-alzheimers","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-neurodegeneration-pathway","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-ad-pathway","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-pathway","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-ad","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-ferroptosis-parkinsons","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-entities-ferroptosis","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-experiments-ferroptosis-parkinsons","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-cell-types-synucleinopathy-neurons","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-synucleinopathy-differential-diagnosis","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-mechanisms-synucleinopathy","link_type":"related","strength":0.5,"evidence":"KG edge: ferroptosis --[contributes_to]--> synucleinopathy"},{"source_artifact_id":"wiki-therapeutics-proteostasis-therapeutics-investment","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"wiki-ideas-payload-proteostasis-triad-pulses","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"wiki-ideas-proteostasis-triad-pulses","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"wiki-mechanisms-proteostasis-network","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"wiki-mechanisms-proteostasis-network-comparison","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"wiki-mechanisms-proteostasis-erad-pathway","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"wiki-companies-proteostasis-therapeutics","link_type":"related","strength":0.5,"evidence":"KG edge: proteasome_complex --[maintains]--> proteostasis"},{"source_artifact_id":"notebook-nb-SDA-2026-04-03-gap-aging-mouse-brain-20260402","link_type":"derives_from","strength":1.0,"evidence":null},{"source_artifact_id":"figure-c7299f1ccd05","link_type":"derives_from","strength":1.0,"evidence":"metadata.analysis_id = SDA-2026-04-03-gap-aging-mouse-brain-20260402"}],"current_artifact_id":"analysis-SDA-2026-04-03-gap-aging-mouse-brain-20260402","is_canonical":true,"supersede_chain":["analysis-SDA-2026-04-03-gap-aging-mouse-brain-20260402"]}