{"artifact":{"id":"analysis-SDA-2026-04-03-gap-seaad-v2-20260402032945","artifact_type":"analysis","entity_ids":null,"title":"Cell type vulnerability in Alzheimer's Disease (SEA-AD data - v2)","quality_score":0.5,"created_by":"crosslink-v2","provenance_chain":null,"content_hash":null,"metadata":{"file_sha256":"4e7cfe24bc05f7b2d16270eadb2fde9768f5c80862cfd2762c18497d101e076f","_schema_version":1},"created_at":"2026-04-10T10:46:29.593192-07:00","updated_at":"2026-04-10T17:46:30-07:00","version_number":6,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-10T10:46:29.593192-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"d0524c50-07f8-47a4-bd60-fe6f8c339e4c","artifact_dir":"data/scidex-artifacts/d0/d0524c50-07f8-47a4-bd60-fe6f8c339e4c","primary_filename":"sda-2026-04-03-gap-seaad-v2-20260402032945.html","accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":"2026-04-28T20:23:44.170759-07:00","hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-v2"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"notebook-SDA-2026-04-03-gap-seaad-v2-20260402032945","link_type":"produces","strength":1.0,"evidence":"CI notebook coverage stub registration"},{"target_artifact_id":"wiki-cell-types-microglia","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Microglia"},{"target_artifact_id":"wiki-entities-oligodendrocytes","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Oligodendrocytes"},{"target_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Alzheimer's Disease"},{"target_artifact_id":"wiki-entities-microglia","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Microglia"},{"target_artifact_id":"wiki-projects-allen-brain-cell-atlas","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Allen Brain Cell Atlas"},{"target_artifact_id":"wiki-mechanisms","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Mechanisms"},{"target_artifact_id":"wiki-cell-types","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Cell Types"},{"target_artifact_id":"wiki-cell-types-oligodendrocytes","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Oligodendrocytes"},{"target_artifact_id":"wiki-entities-astrocytes","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Astrocytes"},{"target_artifact_id":"wiki-cell-types-astrocytes","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Astrocytes"},{"target_artifact_id":"wiki-genes-slc1a2","link_type":"related","strength":0.5850000000000001,"evidence":"Reverse: KG edge: h-019c56c1 --[targets]--> SLC1A2"},{"target_artifact_id":"wiki-projects-sea-ad","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: SEA"}],"incoming_links":[{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-cell-types-microglia","link_type":"mentions","strength":0.6,"evidence":"Title match: Microglia"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-entities-oligodendrocytes","link_type":"mentions","strength":0.6,"evidence":"Title match: Oligodendrocytes"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-alzheimers-disease","link_type":"mentions","strength":0.6,"evidence":"Title match: Alzheimer's Disease"},{"source_artifact_id":"wiki-entities-microglia","link_type":"mentions","strength":0.6,"evidence":"Title match: Microglia"},{"source_artifact_id":"wiki-projects-allen-brain-cell-atlas","link_type":"mentions","strength":0.6,"evidence":"Title match: Allen Brain Cell Atlas"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Title match: Mechanisms"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-cell-types","link_type":"mentions","strength":0.6,"evidence":"Title match: Cell Types"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-cell-types-oligodendrocytes","link_type":"mentions","strength":0.6,"evidence":"Title match: Oligodendrocytes"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-entities-astrocytes","link_type":"mentions","strength":0.6,"evidence":"Title match: Astrocytes"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-cell-types-astrocytes","link_type":"mentions","strength":0.6,"evidence":"Title match: Astrocytes"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-genes-bmp4","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 --[causes]--> oligodendrocyte_dysfunction"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-genes-c3","link_type":"related","strength":0.5,"evidence":"KG edge: C3 --[activates]--> complement_cascade"},{"source_artifact_id":"wiki-genes-eif2ak3","link_type":"related","strength":0.5,"evidence":"KG edge: EIF2AK3 --[mediates]--> integrated_stress_response"},{"source_artifact_id":"wiki-proteins-parp1","link_type":"related","strength":0.5,"evidence":"KG edge: PARP1 --[mediates]--> DNA_repair"},{"source_artifact_id":"wiki-genes-parp1","link_type":"related","strength":0.5,"evidence":"KG edge: PARP1 --[mediates]--> DNA_repair"},{"source_artifact_id":"wiki-genes-syn1","link_type":"related","strength":0.5,"evidence":"KG edge: SYN1 --[regulates]--> synaptic_vesicle_recycling"},{"source_artifact_id":"wiki-proteins-trem2","link_type":"related","strength":0.5,"evidence":"KG edge: TREM2 --[regulates]--> microglia_activation"},{"source_artifact_id":"wiki-genes-trem2","link_type":"related","strength":0.5,"evidence":"KG edge: TREM2 --[regulates]--> microglia_activation"},{"source_artifact_id":"wiki-hypotheses-trem2-alpha-synuclein-clearance-parkinsons","link_type":"related","strength":0.5,"evidence":"KG edge: TREM2 --[regulates]--> microglia_activation"},{"source_artifact_id":"wiki-mechanisms-trem2","link_type":"related","strength":0.5,"evidence":"KG edge: TREM2 --[regulates]--> microglia_activation"},{"source_artifact_id":"wiki-biomarkers-strem2-soluble-trem2","link_type":"related","strength":0.5,"evidence":"KG edge: TREM2 --[regulates]--> microglia_activation"},{"source_artifact_id":"wiki-entities-trem2-protein","link_type":"related","strength":0.5,"evidence":"KG edge: TREM2 --[regulates]--> microglia_activation"},{"source_artifact_id":"wiki-genes-slc1a2","link_type":"related","strength":0.65,"evidence":"KG edge: h-019c56c1 --[targets]--> SLC1A2"},{"source_artifact_id":"wiki-genes-dlx1","link_type":"related","strength":0.55,"evidence":"KG edge: h-0bdc3803 --[targets]--> DLX1"},{"source_artifact_id":"wiki-genes-sox10","link_type":"related","strength":0.55,"evidence":"KG edge: h-0bdc3803 --[targets]--> SOX10"},{"source_artifact_id":"wiki-genes-bmpr1a","link_type":"related","strength":0.5,"evidence":"KG edge: h-e064f134 --[targets]--> BMPR1A"},{"source_artifact_id":"wiki-genes-xrcc1","link_type":"related","strength":0.55,"evidence":"KG edge: h-fa7ac9cb --[targets]--> XRCC1"},{"source_artifact_id":"wiki-mechanisms-ad-neuroinflammation-microglia-pathway","link_type":"related","strength":0.5,"evidence":"KG edge: microglial_activation --[mediates]--> neuroinflammation"},{"source_artifact_id":"wiki-mechanisms-cbs-neuroinflammation","link_type":"related","strength":0.5,"evidence":"KG edge: microglial_activation --[mediates]--> neuroinflammation"},{"source_artifact_id":"wiki-mechanisms-cbd-neuroinflammation","link_type":"related","strength":0.5,"evidence":"KG edge: microglial_activation --[mediates]--> neuroinflammation"},{"source_artifact_id":"wiki-mechanisms-pd-neuroinflammation","link_type":"related","strength":0.5,"evidence":"KG edge: microglial_activation --[mediates]--> neuroinflammation"},{"source_artifact_id":"wiki-mechanisms-neuroinflammation","link_type":"related","strength":0.5,"evidence":"KG edge: microglial_activation --[mediates]--> neuroinflammation"},{"source_artifact_id":"wiki-diagnostics-cbs-psp-neuroinflammation-pet","link_type":"related","strength":0.5,"evidence":"KG edge: microglial_activation --[mediates]--> neuroinflammation"},{"source_artifact_id":"wiki-clinical-trials-synaptic-loss-msa-nct05121012","link_type":"related","strength":0.5,"evidence":"KG edge: tripartite_synapse_dysfunction --[causes]--> synaptic_loss"},{"source_artifact_id":"wiki-cell-types-synaptic-loss-neurons","link_type":"related","strength":0.5,"evidence":"KG edge: tripartite_synapse_dysfunction --[causes]--> synaptic_loss"},{"source_artifact_id":"wiki-mechanisms-synaptic-loss-ad-pathway","link_type":"related","strength":0.5,"evidence":"KG edge: tripartite_synapse_dysfunction --[causes]--> synaptic_loss"},{"source_artifact_id":"wiki-mechanisms-synaptic-loss-neurodegeneration","link_type":"related","strength":0.5,"evidence":"KG edge: tripartite_synapse_dysfunction --[causes]--> synaptic_loss"},{"source_artifact_id":"wiki-mechanisms-synaptic-loss","link_type":"related","strength":0.5,"evidence":"KG edge: tripartite_synapse_dysfunction --[causes]--> synaptic_loss"},{"source_artifact_id":"wiki-mechanisms-synaptic-loss-ad","link_type":"related","strength":0.5,"evidence":"KG edge: tripartite_synapse_dysfunction --[causes]--> synaptic_loss"},{"source_artifact_id":"wiki-projects-sea-ad","link_type":"mentions","strength":0.6,"evidence":"Gene mention: SEA"},{"source_artifact_id":"notebook-SDA-2026-04-03-gap-seaad-v2-20260402032945","link_type":"derives_from","strength":1.0,"evidence":"CI notebook coverage stub registration"},{"source_artifact_id":"wiki-ai-tool-biorxiv-literature-agent","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-openai-codex-biology","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-alibaba-tongyi-qianwen-bio","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tools-inference-bio","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-bioframe","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-nucleus-dnastack","link_type":"related","strength":0.5,"evidence":"KG edge: BMP4 and BMPR1A --[associated_with]--> neurodegeneration"},{"source_artifact_id":"wiki-genes-trem2","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: TREM2"},{"source_artifact_id":"wiki-proteins-trem2","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: TREM2"},{"source_artifact_id":"wiki-entities-trem2","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: TREM2"},{"source_artifact_id":"wiki-genes-apoe","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: APOE"},{"source_artifact_id":"wiki-proteins-apoe","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: APOE"},{"source_artifact_id":"wiki-genes-parp1","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: PARP1"},{"source_artifact_id":"wiki-proteins-parp1","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: PARP1"},{"source_artifact_id":"wiki-genes-bmp4","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: BMP4"},{"source_artifact_id":"wiki-genes-syn1","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: SYN1"},{"source_artifact_id":"wiki-genes-slc1a2","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: SLC1A2"},{"source_artifact_id":"wiki-genes-eif2ak3","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: EIF2AK3"},{"source_artifact_id":"wiki-genes-sox10","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: SOX10"},{"source_artifact_id":"notebook-nb-SDA-2026-04-03-gap-seaad-v2-20260402032945","link_type":"derives_from","strength":1.0,"evidence":null},{"source_artifact_id":"figure-daa07608298b","link_type":"derives_from","strength":1.0,"evidence":"metadata.analysis_id = SDA-2026-04-03-gap-seaad-v2-20260402032945"},{"source_artifact_id":"figure-b81be778c47f","link_type":"derives_from","strength":1.0,"evidence":"metadata.analysis_id = SDA-2026-04-03-gap-seaad-v2-20260402032945"},{"source_artifact_id":"figure-5f7ff10a5459","link_type":"derives_from","strength":1.0,"evidence":"metadata.analysis_id = SDA-2026-04-03-gap-seaad-v2-20260402032945"}],"current_artifact_id":"analysis-SDA-2026-04-03-gap-seaad-v2-20260402032945","is_canonical":true,"supersede_chain":["analysis-SDA-2026-04-03-gap-seaad-v2-20260402032945"]}