{"artifact":{"id":"analysis-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","artifact_type":"analysis","entity_ids":"[]","title":"What are the minimal structural requirements for HSP70/HSP90 inhibitors to achieve tau-selectivity over essential cellular functions? — Analysis","quality_score":0.4,"created_by":"orchestra-ci","provenance_chain":"[{\"step\": \"ci_notebook_stub_link_repair\", \"analysis_id\": \"SDA-2026-04-09-gap-debate-20260409-201742-5407d57d\", \"timestamp\": \"2026-04-12T23:44:28.289564+00:00\"}]","content_hash":null,"metadata":{"stub":true,"source":"ci_notebook_coverage","analysis_id":"SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","file_sha256":"9382b62e6a44b4765847844e6009f65491208de0691d555d487b80201adf60fa","_schema_version":1},"created_at":"2026-04-12T16:44:28.289564-07:00","updated_at":"2026-04-12T16:44:28.289564-07:00","version_number":6,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"ci_stub","origin_url":null,"lifecycle_changed_at":"2026-04-12T16:44:28.289564-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"f8cc6032-8c3d-4839-8a3a-2d737bb893c2","artifact_dir":"data/scidex-artifacts/f8/f8cc6032-8c3d-4839-8a3a-2d737bb893c2","primary_filename":"sda-2026-04-09-gap-debate-20260409-201742-5407d57d.html","accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":"2026-04-28T20:23:45.073064-07:00","hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"orchestra-ci"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-events","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Events"},{"target_artifact_id":"wiki-proteins-hsp90","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-genes-hsp70","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-ideas-payload-hsp70-inducer-therapy","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-therapeutics-hsp90-inhibitors-neurodegeneration","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-proteins-hsp90-protein","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-proteins-hsp70-protein","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-therapeutics-hsp70-hsp90-modulators","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-therapeutics-hsp70-inducer-therapies-neurodegeneration","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-proteins-hsp70","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-ideas-hsp70-inducer-therapies","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-ideas-hsp90-cdc37-modulation","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-cell-types-betz-cells-hsp","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: HSP"},{"target_artifact_id":"wiki-mechanisms-hsp70-hsp90-chaperone-pathway-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"wiki-companies-ad-hsp70-hsp90-chaperone-protein-folding-therapy-companies","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-entities-hsp90-protein","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-therapeutics-hsp90-inhibitors-parkinsons","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: HSP90"},{"target_artifact_id":"wiki-proteins-hsp70-protein-family","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: HSP70"},{"target_artifact_id":"notebook-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","link_type":"produces","strength":1.0,"evidence":"CI notebook coverage stub registration"},{"target_artifact_id":"wiki-genes-hsp70","link_type":"mentions","strength":0.5,"evidence":"Entity HSP70 in analysis"},{"target_artifact_id":"wiki-proteins-hsp90","link_type":"mentions","strength":0.5,"evidence":"Entity HSP90 in analysis"}],"incoming_links":[{"source_artifact_id":"wiki-events","link_type":"mentions","strength":0.6,"evidence":"Title match: Events"},{"source_artifact_id":"wiki-proteins-hsp90","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-genes-hsp70","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-ideas-payload-hsp70-inducer-therapy","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-therapeutics-hsp90-inhibitors-neurodegeneration","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-proteins-hsp90-protein","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-proteins-hsp70-protein","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-therapeutics-hsp70-hsp90-modulators","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-therapeutics-hsp70-inducer-therapies-neurodegeneration","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-proteins-hsp70","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-ideas-hsp70-inducer-therapies","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-ideas-hsp90-cdc37-modulation","link_type":"mentions","strength":0.75,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-cell-types-betz-cells-hsp","link_type":"mentions","strength":0.6,"evidence":"Gene mention: HSP"},{"source_artifact_id":"wiki-mechanisms-hsp70-hsp90-chaperone-pathway-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"wiki-companies-ad-hsp70-hsp90-chaperone-protein-folding-therapy-companies","link_type":"mentions","strength":0.6,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-entities-hsp90-protein","link_type":"mentions","strength":0.6,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-therapeutics-hsp90-inhibitors-parkinsons","link_type":"mentions","strength":0.6,"evidence":"Gene mention: HSP90"},{"source_artifact_id":"wiki-proteins-hsp70-protein-family","link_type":"mentions","strength":0.6,"evidence":"Gene mention: HSP70"},{"source_artifact_id":"notebook-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","link_type":"derives_from","strength":1.0,"evidence":"CI notebook coverage stub registration"},{"source_artifact_id":"notebook-nb-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","link_type":"derives_from","strength":1.0,"evidence":null}],"current_artifact_id":"analysis-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d","is_canonical":true,"supersede_chain":["analysis-SDA-2026-04-09-gap-debate-20260409-201742-5407d57d"]}