{"artifact":{"id":"analysis-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","artifact_type":"analysis","entity_ids":null,"title":"What is the therapeutic window between insufficient and toxic levels of TDP-43 arginine methylation?","quality_score":0.5,"created_by":"crosslink-v2","provenance_chain":null,"content_hash":null,"metadata":{"file_sha256":"37ba6c6badd14f1d1bbee46ccba4e730e457d100f30e15addd4cecfe3d27acc0","_schema_version":1},"created_at":"2026-04-12T23:39:49.479216-07:00","updated_at":"2026-04-13T06:39:50-07:00","version_number":6,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-12T23:39:49.479216-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"0591663f-c994-4251-b899-b3c6162e51f9","artifact_dir":"data/scidex-artifacts/05/0591663f-c994-4251-b899-b3c6162e51f9","primary_filename":"sda-2026-04-12-gap-debate-20260410-113051-5dce7651.html","accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":"2026-04-28T20:23:45.118142-07:00","hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"crosslink-v2"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-events","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Events"},{"target_artifact_id":"wiki-diseases-tdp-43-pathology-corticobasal-syndrome","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp43-rna-granule-pathway","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-tdp-43-protein","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-experiments-tdp43-tau-pathology-determination-ftd","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-tdp43-protein","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp-43-reversibility-als","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-gaps-tdp-43-pet-ligand-ftd","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp-43-fus-rna-proteinopathy-comparison","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-cell-types-tdp43-proteinopathy","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-als-tdp43-pathway","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-cell-types-tdp-43-proteinopathy-neurons","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp43-dna-repair-als-dementia","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-biomarkers-tdp-43","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-cell-types-ftd-tdp-43-neurons","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-cell-types-tdp-43-aggregate-neurons","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp-43-proteinopathy","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-als-tdp43-pathology","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-experiments-tdp43-pet-ligand-development","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-tar-db-protein","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp-43-cortico-basal-syndrome","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-tdp43_protein","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-ideas-payload-tdp43-splicing-modulation-therapy","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-investment-tdp-43-proteinopathy","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-tdp-43-cbs","link_type":"related","strength":0.675,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-gaps-tau-vs-tdp-43-fate-switching-ftd","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-experiments-ftld-tau-tdp-biomarker-differentiation","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-vcp-tdp-43-als-ftd-causal-chain","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-ftld-tdp-subtypes-mechanisms","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-ftd-tdp-pathology","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-proteins-tdp-43","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-mechanisms-ad-ftd-tau-tdp-overlap-comparison","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"wiki-biomarkers-ftld-tau-tdp-distinction","link_type":"related","strength":0.54,"evidence":"Reverse: Gene mention: TDP"},{"target_artifact_id":"notebook-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","link_type":"produces","strength":1.0,"evidence":"CI notebook coverage stub registration"}],"incoming_links":[{"source_artifact_id":"wiki-events","link_type":"mentions","strength":0.6,"evidence":"Title match: Events"},{"source_artifact_id":"wiki-diseases-tdp-43-pathology-corticobasal-syndrome","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-pkan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-india-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-china-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-economic-burden-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mpan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-nbia","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-disease-progression","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-japan-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-tdp43-rna-granule-pathway","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-proteins-tdp-43-protein","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-manganism","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-experiments-tdp43-tau-pathology-determination-ftd","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-proteins-tdp43-protein","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-tdp-43-reversibility-als","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-gaps-tdp-43-pet-ligand-ftd","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-familial-vs-sporadic-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-tdp-43-fus-rna-proteinopathy-comparison","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-cell-types-tdp43-proteinopathy","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-european-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-daly-methodology-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-mitochondrial-dysfunction-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-als-tdp43-pathway","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-cell-types-tdp-43-proteinopathy-neurons","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-tdp43-dna-repair-als-dementia","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-pla2g6-associated-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-biomarkers-tdp-43","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-cell-types-ftd-tdp-43-neurons","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-sleep-disorders-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-cell-types-tdp-43-aggregate-neurons","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-tdp-43-proteinopathy","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-als-tdp43-pathology","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-experiments-tdp43-pet-ligand-development","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-neurodegeneration-impact-measures","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-proteins-tar-db-protein","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-tdp-43-cortico-basal-syndrome","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-pantothenate-kinase-associated-neurodegeneration-pkan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-proteins-tdp43_protein","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-ideas-payload-tdp43-splicing-modulation-therapy","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-investment-tdp-43-proteinopathy","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-mitochondrial-neurodegeneration-comparison","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-tdp-43-cbs","link_type":"mentions","strength":0.75,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-diseases-bpan","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-global-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-us-neurodegeneration-epidemiology","link_type":"mentions","strength":0.5,"evidence":"Domain match: neurodegeneration"},{"source_artifact_id":"wiki-diseases-neurodegeneration","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tools-inference-bio","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-bioframe","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-nucleus-dnastack","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-biorxiv-literature-agent","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-openai-codex-biology","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-ai-tool-alibaba-tongyi-qianwen-bio","link_type":"related","strength":0.598,"evidence":"KG edge: HSPB1 --[promoted: HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 Liquid-Liquid Phase Separation]--> neurodegeneration"},{"source_artifact_id":"wiki-gaps-tau-vs-tdp-43-fate-switching-ftd","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-experiments-ftld-tau-tdp-biomarker-differentiation","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-vcp-tdp-43-als-ftd-causal-chain","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-ftld-tdp-subtypes-mechanisms","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-ftd-tdp-pathology","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-proteins-tdp-43","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-mechanisms-ad-ftd-tau-tdp-overlap-comparison","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"wiki-biomarkers-ftld-tau-tdp-distinction","link_type":"mentions","strength":0.6,"evidence":"Gene mention: TDP"},{"source_artifact_id":"notebook-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","link_type":"derives_from","strength":1.0,"evidence":"CI notebook coverage stub registration"},{"source_artifact_id":"wiki-genes-mapk14","link_type":"related","strength":0.7,"evidence":"Analysis investigates gene: MAPK14"},{"source_artifact_id":"notebook-nb-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","link_type":"derives_from","strength":1.0,"evidence":null}],"current_artifact_id":"analysis-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651","is_canonical":true,"supersede_chain":["analysis-SDA-2026-04-12-gap-debate-20260410-113051-5dce7651"]}