{"artifact":{"id":"analysis_proposal-0c3439b9-c5e6-4503-b8f1-c1b6e9025e36","artifact_type":"analysis_proposal","entity_ids":"[\"SLC16A1\", \"neurodegeneration\"]","title":"Analysis Proposal: SLC16A1 -> neurodegeneration [implicated_in]","quality_score":0.5,"created_by":"analysis_proposal_generator","provenance_chain":"[]","content_hash":"e7c00b07b296e8177fb0c406239325b360b85b76b8d4587f21985837b166eaec","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-28T06:46:24.653776"},"methods":["Differential expression analysis comparing neurodegeneration cases vs. controls with fold-change and p-value thresholds","Weighted gene co-expression network analysis (WGCNA) to identify SLC16A1 module membership in neurodegeneration-related modules","Protein-protein interaction network analysis using STRING database to map SLC16A1 connectivity to known neurodegeneration proteins","Literature-based curation using PubMed text mining to quantify reported associations and mechanistic evidence"],"datasets":["GTEx RNA-seq whole blood and brain tissue expression data","GEO datasets: GSE5281 (hippocampal transcription in AD), GSE7623 (substantia nigra in PD)","AMP-AD consortium proteomic data from prefrontal cortex"],"edge_count":1,"source_entity":"SLC16A1","target_entity":"neurodegeneration","edge_signature":"[\"SLC16A1|neurodegeneration|implicated_in\"]","_schema_version":1,"confidence_range":[0.4,0.4],"expected_outputs":["Significant upregulation or downregulation of SLC16A1 mRNA in affected brain regions (log2FC > 0.5 or < -0.5, adj p-value < 0.05) supporting implicating role","High module membership correlation (kME > 0.7) linking SLC16A1 to neurodegeneration-associated co-expression modules","Enrichment of known neurodegeneration proteins (APP, SNCA, MAPT, LRRK2) in SLC16A1 direct interactome ( STRING confidence > 0.7)","Confirmation of mechanistic literature linking SLC16A1-mediated lactate transport to neuronal metabolic stress in neurodegeneration"],"source_relations":["implicated_in"],"analysis_question":"Can we validate the relationship between SLC16A1 and neurodegeneration using transcriptomic, proteomic, and network-based approaches?"},"created_at":"2026-04-27T23:46:24.653871-07:00","updated_at":"2026-04-27T23:46:24.653871-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"619f92af-9bb3-46d7-ac21-0e8acad7e962","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"analysis_proposal_generator"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"kg_edge-1e04d4271776","link_type":"derives_from","strength":0.5,"evidence":"Proposal derives from source low-confidence KG edge"},{"target_artifact_id":"wiki-genes-slc16a1","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"},{"target_artifact_id":"wiki-neurodegeneration","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"}],"incoming_links":[],"current_artifact_id":"analysis_proposal-0c3439b9-c5e6-4503-b8f1-c1b6e9025e36","is_canonical":true,"supersede_chain":["analysis_proposal-0c3439b9-c5e6-4503-b8f1-c1b6e9025e36"]}