{"artifact":{"id":"analysis_proposal-513624a6-0646-4832-a7c7-16ecb22a6647","artifact_type":"analysis_proposal","entity_ids":"[\"SLC7A11\", \"GPX4\"]","title":"Analysis Proposal: SLC7A11 -> GPX4 [co_discussed, interacts_with]","quality_score":0.5,"created_by":"analysis_proposal_generator","provenance_chain":"[]","content_hash":"78a9de48809a3b0d0d9cda44cbb5c03b15ee78e7de0436d224002b4fe6b4965a","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-28T06:37:19.250508"},"methods":["Spearman correlation analysis of SLC7A11 and GPX4 co-expression across brain regions and disease states","Bayesian integration of multi-modal evidence (expression, PPI, pathway overlap) to compute edge confidence scores","Gene Set Enrichment Analysis (GSEA) for shared ferroptosis and oxidative stress pathways","Text-mining validation using co-occurrence frequency in PubMed abstracts from neurodegeneration literature"],"datasets":["GTEx brain tissue RNA-seq (v8)","ADNI/ROSMAP bulk RNA-seq prefrontal cortex","STRING protein-protein interaction database (v11.5)","FerrDb ferroptosis regulator dataset"],"edge_count":2,"source_entity":"SLC7A11","target_entity":"GPX4","edge_signature":"[\"SLC7A11|GPX4|co_discussed\", \"SLC7A11|GPX4|interacts_with\"]","_schema_version":1,"confidence_range":[0.4,0.8],"expected_outputs":["Significant positive Spearman correlation (ρ > 0.3, FDR < 0.05) in human brain datasets supporting coordinated regulation","Bayesian posterior probability > 0.7 for the interacts_with edge integrating PPI evidence from STRING (combined score ≥ 0.7)","Enrichment of SLC7A11-GPX4 co-mention in ferroptosis, ALS, and Alzheimer's contexts (OR > 2, p < 0.01)","Confirmation would elevate edge trust to ≥ 0.75; refutation would trigger edge removal or demotion to 'weakly_associated'"],"source_relations":["co_discussed","interacts_with"],"analysis_question":"Can we validate the co-expression and interaction relationship between SLC7A11 (cystine transporter) and GPX4 (lipid peroxidase) in neurodegeneration contexts?"},"created_at":"2026-04-27T23:37:19.250604-07:00","updated_at":"2026-04-27T23:37:19.250604-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":null,"citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":null,"contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"9b0e9682-3e9f-4000-a38f-3b3e12fa277a","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"analysis_proposal_generator"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"kg_edge-a80a84c21951","link_type":"derives_from","strength":0.5,"evidence":"Proposal derives from source low-confidence KG edge"},{"target_artifact_id":"kg_edge-fa4931b1da51","link_type":"derives_from","strength":0.5,"evidence":"Proposal derives from source low-confidence KG edge"},{"target_artifact_id":"wiki-genes-slc7a11","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"},{"target_artifact_id":"wiki-proteins-gpx4","link_type":"cites","strength":0.5,"evidence":"Proposal cites relevant entity wiki page"}],"incoming_links":[],"current_artifact_id":"analysis_proposal-513624a6-0646-4832-a7c7-16ecb22a6647","is_canonical":true,"supersede_chain":["analysis_proposal-513624a6-0646-4832-a7c7-16ecb22a6647"]}