{"artifact":{"id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","artifact_type":"experiment","entity_ids":"[\"PACAP, PSD95, synapsin-1, BDNF, eEF2\"]","title":"Synaptic plasticity and protein expression analysis in mPFC","quality_score":0.85,"created_by":"experiment_extractor","provenance_chain":"[]","content_hash":"e028a6155eca88d208089607c31ca31142300f631d97bfd9cf3d84fe52351388","metadata":{"_origin":{"url":null,"type":"internal","tracked_at":"2026-04-10T22:36:30.059833"},"p_value":null,"protocol":"LTP recordings in mPFC slices, protein quantification via Western blot or similar techniques","effect_size":null,"sample_size":null,"source_pmid":"41525914","extracted_at":"2026-04-10T15:36:30.019047","_schema_version":1,"experiment_type":"gene_expression","success_criteria":"Significant improvement in LTP and increased expression of synaptic proteins","expected_outcomes":"ZG treatment would restore impaired LTP and increase synaptic protein expression","statistical_methods":null},"created_at":"2026-04-10T22:36:30-07:00","updated_at":"2026-04-10T22:36:30-07:00","version_number":4,"parent_version_id":null,"version_tag":null,"changelog":null,"is_latest":1,"lifecycle_state":"active","superseded_by":null,"deprecated_at":null,"deprecated_reason":null,"dependencies":null,"market_price":0.5,"origin_type":"internal","origin_url":null,"lifecycle_changed_at":"2026-04-10T22:36:30-07:00","citation_count":0,"embed_count":0,"derivation_count":0,"support_count":0,"contradiction_count":0,"total_usage":0.0,"usage_score":0.5,"usage_computed_at":null,"quality_status":"ok","contributors":[],"answers_question_ids":null,"deprecated_reason_detail":null,"deprecated_reason_code":null,"commit_sha":null,"commit_submodule":null,"last_mutated_at":"2026-05-16T14:51:34.657673-07:00","disputed_at":null,"gap_id":null,"mission_id":null,"intrinsic_priority":null,"effective_priority":null,"artifact_id":"75daf955-bab3-4c3d-bcd1-b3d7fe7ff87c","artifact_dir":null,"primary_filename":null,"accessory_filenames":null,"folder_layout_version":1,"migrated_to_folder_at":null,"hypothesis_id":null,"authorship":{"kind":"human","contributors":[{"role":"author","actor_ref":"experiment_extractor"}]},"epistemic_tier":"T3_provisional","created_by_agent_id":null},"outgoing_links":[{"target_artifact_id":"wiki-genes-psd95","link_type":"related","strength":0.16666666666666666,"evidence":null},{"target_artifact_id":"experiment-exp-5a0902cd-0a2a-4dac-9961-b8863e8ef5ab","link_type":"related","strength":0.16666666666666666,"evidence":null},{"target_artifact_id":"experiment-exp-0a38c5d4-0c9a-4713-92fc-34aaff521153","link_type":"related","strength":0.16666666666666666,"evidence":null},{"target_artifact_id":"wiki-therapeutics-bdnf-therapies","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-mechanisms-long-term-potentiation","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Long-Term Potentiation (LTP)"},{"target_artifact_id":"wiki-investment-bdnf-therapy","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: BDNF"},{"target_artifact_id":"wiki-cell-types-bdnf-neurons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: BDNF"},{"target_artifact_id":"wiki-mechanisms-protein-synthesis","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Protein Synthesis Pathway"},{"target_artifact_id":"wiki-mechanisms-bdnf-signaling-pathway","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-cell-types-brain-derived-neurotrophic-factor-neurons","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: BDNF"},{"target_artifact_id":"wiki-entities-ltp","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Long-Term Potentiation (LTP)"},{"target_artifact_id":"wiki-cell-types-pacap-vpac-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PACAP"},{"target_artifact_id":"wiki-cell-types-pacap-neurons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: PACAP"},{"target_artifact_id":"wiki-proteins-bdnf-protein","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-mechanisms-bdnf-neurotrophin-signaling-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-biomarkers-bdnf-brain-derived-neurotrophic-factor","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-therapeutics-pacap-receptor-modulators-neurodegeneration","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: PACAP"},{"target_artifact_id":"wiki-cell-types-medial-prefrontal-cortex","link_type":"related","strength":0.54,"evidence":"Reverse: Title match: Medial Prefrontal Cortex"},{"target_artifact_id":"wiki-mechanisms-bdnf-trophic-loss-huntingtons","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-proteins-bdnf","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-therapeutics-bdnf-therapy","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-genes-eef2","link_type":"related","strength":0.7200000000000001,"evidence":"Reverse: Gene target: EEF2"},{"target_artifact_id":"wiki-mechanisms-bdnf-signaling-neurodegeneration","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-genes-bdnf","link_type":"related","strength":0.63,"evidence":"Reverse: Gene mention: BDNF"},{"target_artifact_id":"wiki-genes-synapsin-1","link_type":"related","strength":0.63,"evidence":"Reverse: Gene match: synapsin-1"},{"target_artifact_id":"wiki-genes-bdnf","link_type":"mentions","strength":0.5,"evidence":"Entity BDNF in experiment"},{"target_artifact_id":"wiki-genes-psd95","link_type":"mentions","strength":0.5,"evidence":"Entity PSD95 in experiment"}],"incoming_links":[{"source_artifact_id":"wiki-therapeutics-bdnf-therapies","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-mechanisms-long-term-potentiation","link_type":"mentions","strength":0.6,"evidence":"Title match: Long-Term Potentiation (LTP)"},{"source_artifact_id":"wiki-investment-bdnf-therapy","link_type":"mentions","strength":0.8,"evidence":"Gene target: BDNF"},{"source_artifact_id":"wiki-cell-types-bdnf-neurons","link_type":"mentions","strength":0.8,"evidence":"Gene target: BDNF"},{"source_artifact_id":"wiki-mechanisms-protein-synthesis","link_type":"mentions","strength":0.6,"evidence":"Title match: Protein Synthesis Pathway"},{"source_artifact_id":"wiki-mechanisms-bdnf-signaling-pathway","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-cell-types-brain-derived-neurotrophic-factor-neurons","link_type":"mentions","strength":0.8,"evidence":"Gene target: BDNF"},{"source_artifact_id":"wiki-entities-ltp","link_type":"mentions","strength":0.6,"evidence":"Title match: Long-Term Potentiation (LTP)"},{"source_artifact_id":"wiki-genes-psd95","link_type":"mentions","strength":0.8,"evidence":"Gene target: PSD95"},{"source_artifact_id":"wiki-cell-types-pacap-vpac-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PACAP"},{"source_artifact_id":"wiki-cell-types-pacap-neurons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: PACAP"},{"source_artifact_id":"wiki-proteins-bdnf-protein","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-mechanisms-bdnf-neurotrophin-signaling-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-biomarkers-bdnf-brain-derived-neurotrophic-factor","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-therapeutics-pacap-receptor-modulators-neurodegeneration","link_type":"mentions","strength":0.8,"evidence":"Gene target: PACAP"},{"source_artifact_id":"wiki-cell-types-medial-prefrontal-cortex","link_type":"mentions","strength":0.6,"evidence":"Title match: Medial Prefrontal Cortex"},{"source_artifact_id":"wiki-mechanisms-bdnf-trophic-loss-huntingtons","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-proteins-bdnf","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-therapeutics-bdnf-therapy","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-genes-eef2","link_type":"mentions","strength":0.8,"evidence":"Gene target: EEF2"},{"source_artifact_id":"wiki-mechanisms-bdnf-signaling-neurodegeneration","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-genes-bdnf","link_type":"mentions","strength":0.7,"evidence":"Gene mention: BDNF"},{"source_artifact_id":"wiki-genes-synapsin-1","link_type":"mentions","strength":0.7,"evidence":"Gene match: synapsin-1"},{"source_artifact_id":"wiki-therapeutics-neuropeptide-signaling-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: PACAP mentioned 13x in wiki/therapeutics-neuropeptide-signaling-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-advanced-neuropeptide-signaling-cbs-psp","link_type":"mentions","strength":0.5,"evidence":"Content: PACAP mentioned 31x in wiki/therapeutics-advanced-neuropeptide-signaling-cbs-psp"},{"source_artifact_id":"wiki-therapeutics-spam1-sirt6-modulator","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/therapeutics-spam1-sirt6-modulator"},{"source_artifact_id":"wiki-ideas-combo-sirt1-nad-epigenetic-metabolic","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/ideas-combo-sirt1-nad-epigenetic-metabolic"},{"source_artifact_id":"wiki-ideas-payload-complement-pathway-inhibition-therapy","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/ideas-payload-complement-pathway-inhibition-therapy"},{"source_artifact_id":"wiki-cell-types-dendritic-spines","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 5x in wiki/cell-types-dendritic-spines"},{"source_artifact_id":"wiki-cell-types-vasoactive-intestinal-peptide-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-vasoactive-intestinal-peptide-neurons"},{"source_artifact_id":"wiki-cell-types-postsynaptic-densities","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 8x in wiki/cell-types-postsynaptic-densities"},{"source_artifact_id":"wiki-cell-types-shank-neurons-revisited","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 5x in wiki/cell-types-shank-neurons-revisited"},{"source_artifact_id":"wiki-cell-types-arcuate-nucleus-dopamine-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-arcuate-nucleus-dopamine-neurons"},{"source_artifact_id":"wiki-cell-types-striatal-cholinergic-interneurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-striatal-cholinergic-interneurons"},{"source_artifact_id":"wiki-cell-types-edinger-westphal-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-edinger-westphal-nucleus"},{"source_artifact_id":"wiki-cell-types-hippocampal-ca3-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 3x in wiki/cell-types-hippocampal-ca3-neurons"},{"source_artifact_id":"wiki-cell-types-pacap-r1-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PACAP mentioned 16x in wiki/cell-types-pacap-r1-neurons"},{"source_artifact_id":"wiki-cell-types-suprachiasmatic-nucleus-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-suprachiasmatic-nucleus-neurons"},{"source_artifact_id":"wiki-cell-types-vipra2-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PACAP mentioned 6x in wiki/cell-types-vipra2-neurons"},{"source_artifact_id":"wiki-cell-types-parabrachial-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PACAP mentioned 3x in wiki/cell-types-parabrachial-neurons"},{"source_artifact_id":"wiki-cell-types-bed-nucleus-stria-terminalis","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-bed-nucleus-stria-terminalis"},{"source_artifact_id":"wiki-cell-types-dinger-westphal-nucleus","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/cell-types-dinger-westphal-nucleus"},{"source_artifact_id":"wiki-cell-types-dendritic-spine-deficient-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/cell-types-dendritic-spine-deficient-neurons"},{"source_artifact_id":"wiki-cell-types-vipra1-neurons","link_type":"mentions","strength":0.5,"evidence":"Content: PACAP mentioned 7x in wiki/cell-types-vipra1-neurons"},{"source_artifact_id":"wiki-cell-types-ipsc-derived-hippocampal-neurons","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/cell-types-ipsc-derived-hippocampal-neurons"},{"source_artifact_id":"wiki-mechanisms-neurexin-neuroligin-neurodegeneration-modulation","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 5x in wiki/mechanisms-neurexin-neuroligin-neurodegeneration-modulation"},{"source_artifact_id":"wiki-mechanisms-synaptic-dysfunction-hypothesis","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 3x in wiki/mechanisms-synaptic-dysfunction-hypothesis"},{"source_artifact_id":"wiki-mechanisms-synaptic-loss-ad-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 6x in wiki/mechanisms-synaptic-loss-ad-pathway"},{"source_artifact_id":"wiki-mechanisms-transdiagnostic-proteomic-changes","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 3x in wiki/mechanisms-transdiagnostic-proteomic-changes"},{"source_artifact_id":"wiki-mechanisms-5xfad-mouse","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/mechanisms-5xfad-mouse"},{"source_artifact_id":"wiki-mechanisms-convergent-pathways-neurodegeneration","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/mechanisms-convergent-pathways-neurodegeneration"},{"source_artifact_id":"wiki-mechanisms-lrp1-apoe-signaling-cascade","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/mechanisms-lrp1-apoe-signaling-cascade"},{"source_artifact_id":"wiki-mechanisms-synaptic-spine-degradation-pathway","link_type":"mentions","strength":0.5,"evidence":"Content: PSD95 mentioned 5x in wiki/mechanisms-synaptic-spine-degradation-pathway"},{"source_artifact_id":"wiki-mechanisms-spam1-sirt6-positive-allosteric-modulator","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PACAP mentioned 2x in wiki/mechanisms-spam1-sirt6-positive-allosteric-modulator"},{"source_artifact_id":"wiki-mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/mechanisms-apoe-lipid-dysregulation-cognitive-decline-causal-chain"},{"source_artifact_id":"wiki-mechanisms-psp-spatial-transcriptomics","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/mechanisms-psp-spatial-transcriptomics"},{"source_artifact_id":"wiki-diseases-schizophrenia","link_type":"mentions","strength":0.44999999999999996,"evidence":"Content: PSD95 mentioned 2x in wiki/diseases-schizophrenia"},{"source_artifact_id":"open_question-6f91b4d5-64e4-4a8f-bb8d-081dd295dcb6","link_type":"discriminating_experiment","strength":0.58,"evidence":"{\"confidence\": 0.58, \"judge_persona\": \"domain-expert\", \"model\": \"all-MiniLM-L6-v2\"}"}],"current_artifact_id":"experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080","is_canonical":true,"supersede_chain":["experiment-exp-03a934e0-f1ad-47aa-9dcd-9cf748477080"]}